Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice
Abstract
Here, we study the role of a neurosteroid hormone Vitamin D in epilepsy. To examine this problem, we used 1,25-dihydroxyvitamin D, an active form of Vitamin D, injected subcutaneously to NMRI mice (33 microg/20 microl) 40 min prior to seizures induced by systemic injection of pentylenenetrazole (PTZ, 70 mg/kg). Overall, compared to the vehicle-treated control animals (n=11 in each group), the Vitamin D-treated mice demonstrated reduced severity of PTZ-induced seizures (longer latency, shorter duration and lower mortality). In a separate experiment, we assessed the time-course of antiepileptic effects of 1,25-dihydroxyvitamin D. For this, we injected this compound (33 microg/20 microl) to NMRIx129S1 mice (n=11) 40 min, 3, 6, 12 and 24 h prior to seizures, showing that antiepileptic effects were short-term, almost disappearing 3h after administration. Our findings show that Vitamin D plays a direct anticonvulsant role in the brain and suggest that the Vitamin D endocrine system may represent a new target for the development of anticonvulsant drugs.
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Vitamin D and its analogues increase seizure threshold in animal studies.
“Vitamin D and its analogues have been shown to increase seizure threshold, potentiate anticonvulsant activity of antiepileptic drugs, and to decrease the severity of seizures in animal studies [194,195,196].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [194]
Vitamin D and its analogues decrease the severity of seizures in animal studies.
“Vitamin D and its analogues have been shown to increase seizure threshold, potentiate anticonvulsant activity of antiepileptic drugs, and to decrease the severity of seizures in animal studies [194,195,196].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [194]
Vitamin D and its analogues potentiate anticonvulsant activity of antiepileptic drugs in animal studies.
“Vitamin D and its analogues have been shown to increase seizure threshold, potentiate anticonvulsant activity of antiepileptic drugs, and to decrease the severity of seizures in animal studies [194,195,196].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [194]
Cites
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214 · see citing works
Norman, A. W. (1979) · Cited by 3,769 · see citing works
Nongenomic actions of steroid hormones
Lösel, R., & Wehling, M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1009 · Cited by 980 · see citing works
New clues about vitamin D functions in the nervous system
Garcion, E., Wion-Barbot, N., Montero-Menei, C. N., Berger, F., & Wion, D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00547-1 · Cited by 904 · see citing works
Brewer, L. D., Thibault, V., Chen, K.-C., Langub, M. C., Landfield, P. W., & Porter, N. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00098.2001 · Cited by 458 · see citing works
Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug-induced osteomalacia
Pascussi, J., Robert, A., Nguyen, T. M., Walrant-Debray, O., Garabédian, M., Martin, P. G. P., Pineau, T., Saric, J., Navarro, F., Maurel, P., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21867 · Cited by 317 · see citing works
Pathophysiology of bone loss in patients receiving anticonvulsant therapy
Fitzpatrick, L. A. (2004) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2003.11.026 · Cited by 162 · see citing works
Epilepsy and bone health in adults
Pack, A. M., & Morrell, M. J. (2004) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2003.11.029 · Cited by 150 · see citing works
Increased anxiety in mice lacking vitamin D receptor gene
Kalueff, A. V., Lou, Y., Laaksi, I., & Tuohimaa, P. (2004) · Neuroreport · doi:10.1097/01.wnr.0000129370.04248.92 · Cited by 129 · see citing works
Self-citationMechanisms of Neuroprotective Action of Vitamin D3
Kalueff, A. V., Eremin, K. O., & Tuohimaa, P. (2004) · Biochemistry (Moscow) · doi:10.1023/b:biry.0000040196.65686.2f · Cited by 123 · see citing works
Self-citationKalueff, A. V., Lehtimäki, K. A., Ylinen, A., Honkaniemi, J., & Peltola, J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.061 · Cited by 119 · see citing works
Self-citationTreatment of anticonvulsant drug-induced bone disease
Drezner, M. K. (2004) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2003.11.028 · Cited by 115 · see citing works
Synthesis of 1,25‐dihydroxyvitamin D3 by rat brain macrophages in vitro
Neveu, I., Naveilhan, P., Menaa, C., Wion, D., Brachet, P., & Garabédian, M. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380212 · Cited by 114 · see citing works
“Anticonvulsant action” of vitamin D in epileptic patients? A controlled pilot study
Christiansen, C., Rødbro, P., & Sjö, O. (1974) · BMJ · doi:10.1136/bmj.2.5913.258 · Cited by 112 · see citing works
Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3
Norman, A. W., Okamura, W. H., Bishop, J. E., & Henry, H. L. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00273-3 · Cited by 111 · see citing works
Rickets including osteomalacia and tetanty
HESS, A. F. (1929) · Henry Kimpton eBooks · Cited by 104 · see citing works
Siegel, A., Malkowitz, L., Moskovits, M. J., & Christakos, S. (1984) · Brain Research · doi:10.1016/0006-8993(84)91153-3 · Cited by 78 · see citing works
Antiepileptic Drugs and Vitamin D Supplementation
Offermann, G., Pinto, V., & Kruse, R. (1979) · Epilepsia · doi:10.1111/j.1528-1157.1979.tb04771.x · Cited by 57 · see citing works
Sex differences in sensitivity to seizures elicited by pentylenetetrazol in mice
Medina, A. E., Manhães, A. C., & Schmidt, S. L. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00466-x · Cited by 49 · see citing works
Swedberg, M. D. B., Jacobsen, P., & Honoré, T. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10570-3 · Cited by 48 · see citing works
Rickets Including Osteomalacia and Tetany.
(1929) · JAMA · doi:10.1001/jama.1929.02710170063026 · Cited by 46 · see citing works
Loss of Seizure Control Due to Anticonvulsant-Induced Hypocalcemia
Ali, F. E., Al-Bustan, M. A., Al-Busairi, W. A., & Al-Mulla, F. A. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d467 · Cited by 38 · see citing works
Stay tuned to PXR: an orphan actor that may not be D-structive only to bone
Holick, M. F. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523995 · Cited by 34 · see citing works
Stay tuned to PXR: an orphan actor that may not be D-structive only to bone
Holick, M. F. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23995 · Cited by 32 · see citing works
Tusell, J. M., Vendrell, M., Serratosa, J., & Trullás, R. (1992) · Brain Research · doi:10.1016/0006-8993(92)91309-3 · Cited by 32 · see citing works
Vitamin D in the nervous system: actions and therapeutic potential.
Carswell, S., & Feldman, D. (1997) · Cited by 29 · see citing works
Tonic-Clonic Seizures in a Patient with Primary Hypoparathyroidism: A Case Report
Armelisasso, C., Vaccario, M. L., Pontecorvi, A., & Mazza, S. (2004) · Clinical EEG and Neuroscience · doi:10.1177/155005940403500209 · Cited by 27 · see citing works
Oki, J., Takedatsu, M., Itoh, J., Yano, K., Cho, K., & Okuno, A. (1991) · Brain and Development · doi:10.1016/s0387-7604(12)80122-7 · Cited by 22 · see citing works
Tetich, M., Dziedzicka‐Wasylewska, M., Kuśmider, M., Kutner, A., Leśkiewicz, M., Jaworska-Feil, L., Budziszewska, B., Kubera, M., Myint, A.-M., Basta‐Kaim, A., et al. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.034 · Cited by 18 · see citing works
Hoecker, C., & Kanegaye, J. T. (2002) · Journal of Emergency Medicine · doi:10.1016/s0736-4679(02)00570-x · Cited by 16 · see citing works
Pack, A. M. (2004) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-004-0060-2 · Cited by 15 · see citing works
Seizures as the presenting feature of rickets in an infant
Johnson, G. H., & Willis, F. (2003) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2003.tb05293.x · Cited by 14 · see citing works
Increased serum creatine kinase due to hypocalcemia in vitamin D deficiency
Ishikawa, T., Kawai, K., Kanayama, M., & Wada, Y. (1987) · Pediatric Neurology · doi:10.1016/0887-8994(87)90053-1 · Cited by 9 · see citing works
Mikati, M. A., Wakim, R. H., & Fayad, M. N. (2004) · PubMed · Cited by 8 · see citing works
Gupta, M. M., & Grover, D. N. (1977) · Postgraduate Medical Journal · doi:10.1136/pgmj.53.620.330 · Cited by 8 · see citing works
Degkwitz, R. (1934) · Journal of Molecular Medicine · doi:10.1007/bf01781766 · Cited by 6 · see citing works
[Vitamin D-dependent type-1 rickets: diagnosis and treatment of a further case].
Pela, I., Bini, R., & Seracini, D. (1996) · PubMed · Cited by 1 · see citing works
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Cited by
Sorted by citations
Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.07.001 · Cited by 713 · see citing works
McCann, J. C., & Ames, B. N. (2007) · The FASEB Journal · doi:10.1096/fj.07-9326rev · Cited by 409 · see citing works
Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases
de Abreu, D. A. F., Eyles, D. W., & Feron, F. P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.023 · Cited by 379 · see citing works
Harms, L. R., Burne, T. H. J., Eyles, D. W., & McGrath, J. J. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.05.009 · Cited by 265 · see citing works
Neurosteroid hormone vitamin D and its utility in clinical nutrition
Kalueff, A. V., & Tuohimaa, P. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328010ca18 · Cited by 263 · see citing works
Self-citationVitamin D and the brain: Genomic and non-genomic actions
Cui, X., Gooch, H. M., Petty, A. E., McGrath, J. J., & Eyles, D. W. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.035 · Cited by 250 · see citing works
Vitamin D and Ageing: Neurological Issues
Annweiler, C., Schott, A., Berrut, G., Chauviré, V., Gall, D. L., Inzitari, M., & Beauchet, O. (2010) · Neuropsychobiology · doi:10.1159/000318570 · Cited by 234 · see citing works
Testicular adrenal rest tumours in congenital adrenal hyperplasia
Claahsen-van der Grinten, H. L., Otten, B. J., Stikkelbroeck, M. M. L., Sweep, F. C. G. J., & Hermus, A. R. M. M. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.007 · Cited by 187 · see citing works
Vitamin D and autism: Clinical review
Kočovská, E., Fernell, E., Billstedt, E., Minnis, H., & Gillberg, C. (2012) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.02.015 · Cited by 176 · see citing works
Vitamin D in fetal brain development
Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.05.004 · Cited by 145 · see citing works
Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects
Annweiler, C., Montero‐Odasso, M., Schott, A., Berrut, G., Fantino, B., & Beauchet, O. (2010) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-7-50 · Cited by 145 · see citing works
Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110 · see citing works
Cekic, M. M., Sayeed, I., & Stein, D. G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.002 · Cited by 109 · see citing works
Nettekoven, S., Ströhle, A., Trunz, B., Wolters, M., Hoffmann, S., Horn, R., Steinert, M., Brabant, G. E., Lichtinghagen, R., Welkoborsky, H., et al. (2008) · European Journal of Pediatrics · doi:10.1007/s00431-008-0672-7 · Cited by 104 · see citing works
Role of Vitamins in Neurodegenerative Diseases: A Review
Kumar, R. R., Singh, L., Thakur, A., Singh, S., & Kumar, B. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666211119122150 · Cited by 88 · see citing works
Effect of 1α,25‐dihydroxyvitamin D3 in embryonic hippocampal cells
Marini, F., Bartoccini, E., Cascianelli, G., Voccoli, V., Baviglia, M. G., Magni, M. V., Garcia‐Gil, M., & Albi, E. (2009) · Hippocampus · doi:10.1002/hipo.20670 · Cited by 85 · see citing works
Kalueff, A. V., Minasyan, A., Keisala, T., Kuuslahti, M., Miettinen, S., & Tuohimaa, P. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.007 · Cited by 74 · see citing works
Self-citationNutrient Intake of Children with Intractable Epilepsy Compared with Healthy Children
Volpe, S. L., Schall, J. I., Gallagher, P. R., Stallings, V. A., & Bergqvist, A. G. C. (2007) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.03.011 · Cited by 67 · see citing works
Camargo, A., Dalmagro, A. P., Rikel, L., da Silva, E. B., da Silva, K. A. B. S., & Zeni, A. L. B. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.002 · Cited by 61 · see citing works
Molecular insights into the pathogenic impact of vitamin D deficiency in neurological disorders
Anwar, M. J., Alenezi, S. K., & Alhowail, A. H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114718 · Cited by 60 · see citing works
Borowicz, K. K., Morawska, M., Furmanek-Karwowska, K., Luszczki, J. J., & Czuczwar, S. J. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.07.002 · Cited by 55 · see citing works
Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis
Song, L., Luo, X., Jiang, Q., Chen, Z., Zhou, L., Wang, D., & Chen, A. (2020) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2020.18.2.203 · Cited by 54 · see citing works
Functional Nutrients for Epilepsy
Kim, J., & Cho, K. (2019) · Nutrients · doi:10.3390/nu11061309 · Cited by 52 · see citing works
Holló, A., Clemens, Z., & Lakatos, P. L. (2013) · International Journal of Neuroscience · doi:10.3109/00207454.2013.847836 · Cited by 44 · see citing works
Therapeutic and mechanistic intervention of vitamin D in neuropsychiatric disorders
Rihal, V., Khan, H., Kaur, A., Singh, T. G., & Abdel‐Daim, M. M. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114782 · Cited by 42 · see citing works
Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology
Stewart, A., Wong, K., Cachat, J., Elegante, M. F., Gilder, T., Mohnot, S., Wu, N., Minasyan, A., Tuohimaa, P., & Kalueff, A. V. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833c850f · Cited by 40 · see citing works
Self-citationŞahin, S., Gürgen, S. G., Yazar, U., İnce, İ., Kamaşak, T., Arslan, E. A., Durgut, B. D., Dilber, B., & Cansu, A. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.12.005 · Cited by 40 · see citing works
Vitamin D3 for the Treatment of Epilepsy: Basic Mechanisms, Animal Models, and Clinical Trials
Pendo, K., & DeGiorgio, C. M. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00218 · Cited by 39 · see citing works
Epilepsy and vitamin D: a comprehensive review of current knowledge
Yazdi, S. A. M., Abbasi, M., & Yazdi, S. M. M. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0044 · Cited by 39 · see citing works
Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy
Durá-Travé, T., Gallinas-Victoriano, F., Malumbres-Chacón, M., Moreno-González, P., Aguilera, S., & Yoldi-Petri, M. E. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.11.013 · Cited by 39 · see citing works
Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy
Jiang, P., Zhu, W.-Y., He, X., Tang, M., Dang, R.-L., Huan-de, L., Xue, Y., Zhang, L., Wu, Y., & Cao, L.-J. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph121113913 · Cited by 37 · see citing works
Szałwińska, K., Cyuńczyk, M., Kochanowicz, J., & Witkowska, A. M. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00704-6 · Cited by 35 · see citing works
Dong, N., Guo, H., Hu, Y., Jiao, Y., Xu, M., Ding, L., Qiu, J., Jiang, Z., Chen, F., Lu, X., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.968868 · Cited by 31 · see citing works
Vitamin D Deficiency in Children With Newly Diagnosed Idiopathic Epilepsy
Sönmez, F. M., Türkmen, A. D., Namuslu, M., Canbal, M., & Örün, E. (2015) · Journal of Child Neurology · doi:10.1177/0883073814566627 · Cited by 31 · see citing works
Janjoppi, L., Katayama, M. H., Scorza, F. A., Folgueira, M. A. A. K., Brentani, M., Pansani, A. P., Cavalheiro, É. A., & Arida, R. M. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.01.002 · Cited by 28 · see citing works
Elsayed, A. A., Menze, E. T., Tadros, M. G., Ibrahim, B. M. M., Sabri, N. A., & Khalifa, A. E. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1435-7 · Cited by 27 · see citing works
RetractedBrito, V. B., Folmer, V., Puntel, G. O., Fachinetto, R., Soares, J. C. M., Zeni, G. R., Nogueira, C. W., & da Rocha, J. B. T. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.09.007 · Cited by 26 · see citing works
Abdel-Wahab, A. F., Afify, M. A., Mahfouz, A. M., Shahzad, N., Bamagous, G. A., & Ghamdi, S. S. A. (2017) · Brain Research · doi:10.1016/j.brainres.2017.08.011 · Cited by 26 · see citing works
Gholami, M., Saboory, E., Zare, S., Roshan‐Milani, S., & Moghaddam, A. H. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.07.004 · Cited by 25 · see citing works
Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy
DeGiorgio, C. M., Hertling, D., Curtis, A., Murray, D., & Markovic, D. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.03.001 · Cited by 25 · see citing works
Epilepsy treatment by sacrificing vitamin D
Cebeci, A. N., & Ekici, B. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.905742 · Cited by 24 · see citing works
Vitamin D supplementation to prevent vitamin D deficiency for children with epilepsy
Khalifah, R. A. A., Hudairi, A., Homyani, D. K. A., Hamad, M. H., & Bashiri, F. A. (2018) · Medicine · doi:10.1097/md.0000000000012734 · Cited by 22 · see citing works
Effect of Antiepileptic Therapy on Serum 25(OH)D3 and 24,25(OH)2D3 Levels in Epileptic Children
He, X., Jiang, P., Zhu, W.-Y., Xue, Y., Huan-de, L., Dang, R., Cai, H., Tang, M., Zhang, L., & Wu, Y. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000443535 · Cited by 21 · see citing works
Chassoux, F., Navarro, V., Quirins, M., Laurent, A., Gavaret, M., Cousyn, L., Crépon, B., Landré, E., Marchi, A., Soufflet, C., et al. (2024) · Epilepsia · doi:10.1111/epi.18050 · Cited by 20 · see citing works
Borowicz, K. K., Morawska, D., & Morawska, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.01.012 · Cited by 20 · see citing works
Neuroinflammation impact in epileptogenesis and new treatment strategy
Mahfoz, A. M., & Shahzad, N. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000513 · Cited by 19 · see citing works
Liu, Y., Gong, C., Li, J., Ning, X., Zeng, P., Wang, L., Lian, B., Liu, J., Fang, L., & Guo, J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1439279 · Cited by 18 · see citing works
Momeni, S. N., Masoud, S. A., & Banafshe, H. R. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.11.011 · Cited by 17 · see citing works
Assessing Epilepsy-Related Behavioral Phenotypes in Adult Zebrafish
Desmond, D. H., Kyzar, E. J., Gaikwad, S., Green, J. B. A., Riehl, R., Roth, A., Stewart, A., & Kalueff, A. V. (2012) · Neuromethods · doi:10.1007/978-1-61779-597-8_24 · Cited by 16 · see citing works
Self-citationAygün, H., Ayyıldız, M., & Ağar, E. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.106208 · Cited by 15 · see citing works
25‐Hydroxy‐vitamin D levels among Callithrix penicillata primate species raised in captivity
Teixeira, D. S., Castro, L. C., Nóbrega, Y. K. D. M., de Almeida, R. C., Gandolfi, L., & Pratesi, R. (2009) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2009.00399.x · Cited by 14 · see citing works
The Effects of Vitamin D3 and Melatonin Combination on Pentylenetetrazole- induced Seizures in Mice
Mehrzadi, S., Hosseinzadeh, A., Dehdashtian, E., & Jafari‐Sabet, M. (2022) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524922666220429121253 · Cited by 13 · see citing works
Inhibitor effect of paricalcitol in rat model of pentylenetetrazol-induced seizures
Uyanıkgil, Y., Solmaz, V., Çavuşoğlu, T., Çınar, B. P., Çetin, E. Ö., Sur, H. Y., & Erbaş, O. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1273-z · Cited by 11 · see citing works
The effect of vitamin D3 and paricalcitol on penicillin-induced epileptiform activity in rats
Sümbül, O., & Aygün, H. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.106262 · Cited by 11 · see citing works
Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10032-0 · Cited by 9 · see citing works
Riboflavin Deficiency, Brain Function, and Health
Sinigaglia‐Coimbra, R., Lopes, A. C., & Coimbra, C. G. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_153 · Cited by 9 · see citing works
Vitamin D prophylaxis in persons with epilepsy?
Sourbron, J., Auvin, S., Cabral‐Lim, L., Devlin, A. M., Dluglos, D., Hosny, H., Marson, A. G., Meador, K. J., Patel, A. A., Pennell, P. B., et al. (2024) · Epilepsia · doi:10.1111/epi.18046 · Cited by 8 · see citing works
Possible methods for the prevention of bone loss in persons with epilepsy
Elliott, J. O. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.35 · Cited by 8 · see citing works
Pattnaik, S. S., Sarangi, S. C., Dash, Y., Singh, A., Goswami, R., Singh, S., Khan, M. A., Banerjee, J., Datta, S. K., & Tripathi, M. (2025) · Epilepsia · doi:10.1111/epi.18492 · Cited by 7 · see citing works
Womble, P. D., Hodges, S. L., Nolan, S. O., Binder, M. S., Holley, A. J., Herrera, R., Senger, S., Kwok, E. M., Narviaz, D. A., Faust, A. M., et al. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108297 · Cited by 7 · see citing works
Guo, H., Sun, X.-L., Xu, Y., Zhang, Y., Wang, J., Lin, F., Hu, Y., Sun, F., Tang, H. Y., Lu, X., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107022 · Cited by 6 · see citing works
Hosseinzadeh, A., Mehrzadi, S., Dehdashtian, E., & Karimi, M. Y. (2022) · Current Drug Therapy · doi:10.2174/1574885517666220531104009 · Cited by 6 · see citing works
Çığrı, E., & Çatan, F. (2023) · Children · doi:10.3390/children10030528 · Cited by 6 · see citing works
The Neurosteroid Hormone Vitamin D: Modern Prospects
Lebedev, A. S., Shevlyakov, A. D., Ilyin, N. P., Galstyan, D. S., Golushko, N. I., & Kalueff, A. V. (2024) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093024060024 · Cited by 5 · see citing works
Self-citationLiu, J., Li, J., Liu, Y., Liu, R., Fang, L., Jiang, Z., Liu, L., Wang, L., Gong, C., Kong, D., et al. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2592265 · Cited by 5 · see citing works
Mohammadi, M., baleghi, Y., Omran, M. R. S., Hajiahmadi, M., Pornasrollah, M., Alijanpour, P., & Alijanpour, M. (2023) · Global Pediatric Health · doi:10.1177/2333794x231198390 · Cited by 5 · see citing works
Vitamin D Brain Development and Function
Eyles, D. W., & McGrath, J. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809965-0.00033-1 · Cited by 5 · see citing works
In vivo electrophysiological study of vitamin D3 protective effects on PTZ-induced seizures in rats
Gharehaghaji, S. H., Panahi, Y., Khalilzadeh, E., & Saiah, G. V. (2022) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.363596 · Cited by 4 · see citing works
Tahir, H., Munir, N., Iqbal, S. S., Bacha, U., Amir, S., Umar, H., Riaz, M., Tahir, I. M., Shah, S. M. A., Shafiq, A., et al. (2023) · European Journal of Inflammation · doi:10.1177/1721727x231161013 · Cited by 4 · see citing works
Nie, Y., Huang, L., Wang, L., Zeng, P., Gong, C., Lin, S., Guo, J., & Zhou, S. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin25483 · Cited by 3 · see citing works
Jiang, H., & Zhang, S. (2022) · PubMed Central · doi:10.22038/ijbms.2021.60123.13328 · Cited by 3 · see citing works
Adult Vitamin D Deficiency and Adverse Brain Outcomes
Groves, N. J., McGrath, J. J., & Burne, T. H. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809963-6.00115-2 · Cited by 3 · see citing works
Akkaya, R., Akkaya, B., & Bello, R. O. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.134246 · Cited by 2 · see citing works
Sonmez, F. M. (2016) · Journal of Pediatrics & Neonatal Care · doi:10.15406/jpnc.2016.04.00132 · Cited by 2 · see citing works
Annweiler, C. (2012) · Oxidative stress and disease · doi:10.1201/b13714-22 · Cited by 2 · see citing works
Arulsamy, A., & Shaikh, M. F. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-6467-0_7 · Cited by 2 · see citing works
Abbasi, E., Ghazavi, A., & Farahmand, H. (2021) · Studies in Medical Sciences · doi:10.52547/umj.32.9.715 · Cited by 1 · see citing works
El-Ansary, A. K., Alabdali, A. N., Bacha, A. G. B., Alonazi, M. A., & AL-Ayadhi, L. Y. (2025) · Clinical and Translational Neuroscience · doi:10.3390/ctn9020021 · Cited by 1 · see citing works
Liu, J., Li, J., 付茹婷, Fang, L., Liu, Y., Liu, R., Kong, D., Jiang, Z., Liu, L., Wang, L., et al. (2026) · Epilepsy Research · doi:10.1016/j.eplepsyres.2026.107820 · Cited by 1 · see citing works
Du, X., Wang, B., & Shao, L. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.109935 · Cited by 1 · see citing works
Duarte-Donneys, L. M., Ramírez, J. J. O., Cornejo, J. W., Suárez-Brochero, Ó. F., & Cerón, C. A. R. (2022) · Revista Médicas UIS · doi:10.18273/revmed.v35n1-2022007 · Cited by 1 · see citing works
Adult vitamin D deficiency and adverse brain outcomes
Mayne, P., Bradford, D., Groves, N. J., McGrath, J. J., & Burne, T. H. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91386-7.00035-0 · Cited by 1 · see citing works
Bailey, S., & McCaffery, P. J. A. (2010) · Springer eBooks · doi:10.1007/978-90-481-8553-5_5 · Cited by 1 · see citing works
Clemens, Z., Holló, A., Kelemen, A., & Rásonyi, G. (2013)
Mirfakhrai, F., Mohammadi, Z. F., & mohammadi, H. F. (2017) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms.8954
Brito, V. B. (2007) · Americanae (AECID Library)
Kulesza, K., Cyuńczyk, M., Kochanowicz, J., & Witkowska, A. M. (2020) · doi:10.21203/rs.3.rs-78866/v1
VITAMINAS D IR NEUROLOGINIAI SUTRIKIMAI
Vareikaitė, R., Kondratavičiūtė, G., & Petrauskaitė, I. (2023) · Health Sciences · doi:10.35988/sm-hs.2023.248
The impact of vitamin d on psychiatric and physiological mechanisms in the context of epilepsy
Duț, R., Visternicu, M., Miler, A. A., & Ciobica, A. S. (2024) · Bulletin of Integrative Psychiatry · doi:10.36219/bpi.2024.4.01
Szałwińska, K., Cyuńczyk, M., Kochanowicz, J., & Witkowska, A. M. (2021) · Figshare · doi:10.6084/m9.figshare.14880533
Disrupted Vitamin D Signaling and Metabolism in Neurodevelopmental and Neurodegenerative Disorders
Khatibi, N., & MacDonald, J. L. (2026) · ASN NEURO · doi:10.1080/17590914.2026.2617453
Liu, J., Liu, Y., 付茹婷, Fang, L., Kong, D., Wang, L., Zeng, P., Xinru, Z., Fu, Y., Guo, J., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9449541/v1
The impact of antiepileptic therapy on 25(OH)D levels and bone mineral density in epileptic patients
Magomedova, P. M., Жидкова, И. А., Biryukova, E. V., Vlasov, P. N., & Солонский, Д. С. (2026) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2026126091139
- Authors
- Kalueff, A. V., Minasyan, A., & Tuohimaa, P.
- Affiliations
- Tampere University (FI)
- University of Tampere (FI)
- Tampere University Hospital (FI)
- Corresponding author
- Kalueff, Allan V.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 67
- Issue
- 1-2
- Pages
- 156-160
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2155553835
- Cited by
- 94
- References
- 37
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tays
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- 1,25-dihydroxyvitamin D, vitamin D, anticonvulsant activity, epilepsy, pentylenetetrazole-induced seizures, neurosteroids, antiepileptic drug targets
- MeSH terms
- Animals, Anticonvulsants, Brain, Calcitriol, Convulsants, Disease Models, Animal, Epilepsy, Injections, Subcutaneous, Mortality, Pentylenetetrazole, Reaction Time, Time Factors, Mice
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