Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study
Abstract
There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D on seizure control. Here, we measured serum 25-hydroxy-vitamin D (25(OH)D) levels and normalized it by administration of vitamin D3 in 13 patients with pharmacoresistant epilepsy. To see if vitamin D3 has an impact on seizure frequency, we compared seizure numbers during a 90-day period before and after treatment onset. We found that seizure numbers significantly decreased upon vitamin D3 supplementation. Median seizure reduction was 40%. We conclude that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.
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Correction of vitamin D deficiency in patients with seizures decreased the frequency of seizures by 30%-40%.
“Correction of vitamin D deficiency in patients with seizures, decreased the frequency of seizures by 30%–40% [197,198].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [197]
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Vitamin D and Autism Spectrum Disorder: A Literature Review
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- Authors
- Holló, A., Clemens, Z., Kamondi, A., Lakatos, P., & Szűcs, A.
- Affiliations
- National Institute of Medical Rehabilitation (HU)
- Országos Idegsebészeti Tudományos Intézet (HU)
- Corresponding author
- Clemens, Zsófia
- Venue
- Epilepsy & Behavior
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 24
- Issue
- 1
- Pages
- 131-133
- ISSN
- 1525-5050 (ISSN-L)
- OpenAlex
- W2044963253
- Cited by
- 149
- References
- 27
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 15 · 2023: 13 · 2022: 15 · 2021: 15 · 2020: 13 · 2019: 15 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 4 · 2014: 10 · 2013: 11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsy & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- vitamin D deficiency, vitamin D3 supplementation, drug-resistant epilepsy, seizure control, 25-hydroxyvitamin D, anticonvulsant activity, serum vitamin D levels
- MeSH terms
- Adult, Aged, Cholecalciferol, Epilepsy, Female, Humans, Male, Middle Aged, Pilot Projects, Vitamin D, Vitamin D Deficiency, Vitamins, Treatment Outcome, Young Adult
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