Cited by 190Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyElectrolyte and hormonal disorders

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The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia

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Fliers, E., Swaab, D.F., W. Pool, Chr., Verwer, R.W.H.·1985·Brain Research

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Abstract

The neuropeptides vasopressin (AVP) and oxytocin (OXT) are supposed to be involved not only in peripheral functions (e.g. diuresis, labour and lactation) but also in central processes that are frequently disturbed during aging and senile dementia (e.g. fluid and electrolyte homeostasis and cognitive functions). A concomitant decrease in activity of the hypothalamo-neurohypophyseal system (HNS) with aging has been postulated in the literature, but has not yet been established. In order to investigate possible age-related changes in the human HNS, immunocytochemically identified AVP and OXT neurons in the paraventricular and supraoptic nucleus (PVN and SON) were analysed morphometrically in subjects from 10 to 93 years of age, including patients with senile dementia of the Alzheimer type (SDAT). Cell size was used as a parameter for peptide production. Mean profile area of OXT cells did not show any significant changes with increasing age. Mean profile area of AVP cells, however, showed an initial decrease up to the sixth decade of life, after which a gradual increase was observed. Size of AVP and OXT cell nuclei did not change significantly with aging. Observations in brains from patients with SDAT were within the range for their age group. The present results do not support degeneration or diminished function of the HNS in senescence or SDAT, as generally presumed in the literature, but suggest an activation of AVP cells after 80 years of age. The activation of AVP cells in senescence is in accordance with previous findings in the aged Wistar rat.

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Additional file 1 of The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain
Toya, A., Fukada, M., Aoki, E., Matsuki, T., Ueda, M., Eda, S., Hashizume, Y., Iio, A., Masaki, S., & Nakayama, A. (2023) · Figshare · doi:10.6084/m9.figshare.26566853
Impact d'une neuroinflammation transitoire ou chronique à bas bruit sur le fonctionnement neuronal
Marcand-Sauvant, J. (2010) · theses.fr (ABES) · doi:10.70675/2277079ez602ez4b12za4b9z8d9889d96845
Caractérisation pharmacologique du LIT01-196, un analogue de l'apéline-17 métaboliquement stable, et étude de ses effets sur des modèles expérimentaux d'hypertension artérielle et d'hyponatrémie
Flahault, A. (2018) · theses.fr (ABES) · doi:10.70675/69df45d7zd282z4996z811az5bca9c8cbef8
Voies de signalisation activées lors de la stimulation du récepteur de l'apéline, responsables de l'effet hypotenseur de l'apéline
Alvear‐Perez, R. (2019) · theses.fr (ABES) · doi:10.70675/3d2ffd20z5280z48adzbfe2z0d17920a5eea

Authors: Fliers, E., Swaab, D. F., W. Pool, C., & Verwer, R. W. H.
Corresponding author: Fliers, E.
ORCID: Fliers, E.
Swaab, D.F.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1985-09
Volume: 342
Issue: 1
Pages: 45-53
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(85)91351-4
OpenAlex: W2029372047
Cited by: 190
References: 43
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 4
FWCI: 17.96
Type: journal article
Language: en
Open access: green
pure.knaw.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords: vasopressin, oxytocin, supraoptic nucleus, paraventricular nucleus, hypothalamo-neurohypophysial system, aging, senile dementia, Alzheimer's disease, neuropeptide neurons, cell size, fluid and electrolyte balance
MeSH terms: Adolescent, Adult, Aged, Aging, Alzheimer Disease, Arginine Vasopressin, Child, Female, Histocytochemistry, Humans, Immunochemistry, Male, Middle Aged, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Supraoptic Nucleus

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The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia

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