Cited by 190Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyElectrolyte and hormonal disorders

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The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia

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Fliers, E., Swaab, D.F., W. Pool, Chr., Verwer, R.W.H.·1985·Brain Research

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Abstract

The neuropeptides vasopressin (AVP) and oxytocin (OXT) are supposed to be involved not only in peripheral functions (e.g. diuresis, labour and lactation) but also in central processes that are frequently disturbed during aging and senile dementia (e.g. fluid and electrolyte homeostasis and cognitive functions). A concomitant decrease in activity of the hypothalamo-neurohypophyseal system (HNS) with aging has been postulated in the literature, but has not yet been established. In order to investigate possible age-related changes in the human HNS, immunocytochemically identified AVP and OXT neurons in the paraventricular and supraoptic nucleus (PVN and SON) were analysed morphometrically in subjects from 10 to 93 years of age, including patients with senile dementia of the Alzheimer type (SDAT). Cell size was used as a parameter for peptide production. Mean profile area of OXT cells did not show any significant changes with increasing age. Mean profile area of AVP cells, however, showed an initial decrease up to the sixth decade of life, after which a gradual increase was observed. Size of AVP and OXT cell nuclei did not change significantly with aging. Observations in brains from patients with SDAT were within the range for their age group. The present results do not support degeneration or diminished function of the HNS in senescence or SDAT, as generally presumed in the literature, but suggest an activation of AVP cells after 80 years of age. The activation of AVP cells in senescence is in accordance with previous findings in the aged Wistar rat.

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Practical methods for biological morphometry
Weibel, E. R. (1979) · Academic Press eBooks · Cited by 1,563
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
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de Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524
Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretory system of the rat
Vandesande, F., & Dierickx, K. (1975) · Cell and Tissue Research · doi:10.1007/bf00218970 · Cited by 496
�ber die neurosekretorische Verkn�pfung von Hypothalamus und Hypophyse
Bargmann, W. (1949) · Journal of Molecular Medicine · doi:10.1007/bf01484668 · Cited by 448
Immunohistochemical evidence for a neurophysin-containing autonomic pathway arising in the paraventricular nucleus of the hypothalamus
Swanson, L. W. (1977) · Brain Research · doi:10.1016/0006-8993(77)91000-9 · Cited by 430
Progress in Psychoneuroendocrinology
Carroll, B. J. (1982) · Psychoneuroendocrinology · doi:10.1016/0306-4530(82)90058-0 · Cited by 293
DISTRIBUTION OF OXYTOCIN AND VASOPRESSIN IN THE RAT SUPRAOPTIC AND PARAVENTRICULAR NUCLEUS
Swaab, D. F., Nijveldt, F., & Pool, C. W. (1975) · Journal of Endocrinology · doi:10.1677/joe.0.0670461 · Cited by 254
Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.
Cooper, K., Kasting, N. W., Lederis, K. P., & Veale, W. L. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012953 · Cited by 251

Show all 43 references

Research works printed but not linked: 2

Bargmann, 1949, Über die neurosekretorische Verknüpfung von Hypothalamus und Neurohypophyse, Z. Zellforsch. Mikr. Anat., 34, 610
Swaab, 1982, Neuropeptides. The distribution and function in the brain, Vol. 55, 97

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Authors: Fliers, E., Swaab, D. F., W. Pool, C., & Verwer, R. W. H.
Corresponding author: Fliers, E.
ORCID: Fliers, E.
Swaab, D.F.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1985-09
Volume: 342
Issue: 1
Pages: 45-53
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(85)91351-4
OpenAlex: W2029372047
Cited by: 190
References: 43
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 4
FWCI: 17.96
Type: journal article
Language: en
Open access: green
pure.knaw.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords: vasopressin, oxytocin, supraoptic nucleus, paraventricular nucleus, hypothalamo-neurohypophysial system, aging, senile dementia, Alzheimer's disease, neuropeptide neurons, cell size, fluid and electrolyte balance
MeSH terms: Adolescent, Adult, Aged, Aging, Alzheimer Disease, Arginine Vasopressin, Child, Female, Histocytochemistry, Humans, Immunochemistry, Male, Middle Aged, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Supraoptic Nucleus

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The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia

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