The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia
Open accessAbstract
The neuropeptides vasopressin (AVP) and oxytocin (OXT) are supposed to be involved not only in peripheral functions (e.g. diuresis, labour and lactation) but also in central processes that are frequently disturbed during aging and senile dementia (e.g. fluid and electrolyte homeostasis and cognitive functions). A concomitant decrease in activity of the hypothalamo-neurohypophyseal system (HNS) with aging has been postulated in the literature, but has not yet been established. In order to investigate possible age-related changes in the human HNS, immunocytochemically identified AVP and OXT neurons in the paraventricular and supraoptic nucleus (PVN and SON) were analysed morphometrically in subjects from 10 to 93 years of age, including patients with senile dementia of the Alzheimer type (SDAT). Cell size was used as a parameter for peptide production. Mean profile area of OXT cells did not show any significant changes with increasing age. Mean profile area of AVP cells, however, showed an initial decrease up to the sixth decade of life, after which a gradual increase was observed. Size of AVP and OXT cell nuclei did not change significantly with aging. Observations in brains from patients with SDAT were within the range for their age group. The present results do not support degeneration or diminished function of the HNS in senescence or SDAT, as generally presumed in the literature, but suggest an activation of AVP cells after 80 years of age. The activation of AVP cells in senescence is in accordance with previous findings in the aged Wistar rat.
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“There is also a lack of sex differences in OT neuron size and number in humans”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Fliers et al., 1985
In the citing paper
“In Homo, males and females do no differ in the number or size of OT-ir neurons in the neurohypophyseal tract (Fliers et al., 1985; Ishunina and Swaab, 1999; Wierda et al., 1991).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Fliers et al., 1985
In the citing paper
“As indicated by Willison et al. (Fliers et al., 1985), oscillations in the suprachiasmatic nuclei are disrupted in α-synuclein transgenic mice quite early in the development of the disease.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Fliers et al., 1985
Citations
Cites
Practical methods for biological morphometry
Weibel, E. R. (1979) · Academic Press eBooks · Cited by 1,563
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
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�ber die neurosekretorische Verkn�pfung von Hypothalamus und Hypophyse
Bargmann, W. (1949) · Journal of Molecular Medicine · doi:10.1007/bf01484668 · Cited by 448
Swanson, L. W. (1977) · Brain Research · doi:10.1016/0006-8993(77)91000-9 · Cited by 430
Progress in Psychoneuroendocrinology
Carroll, B. J. (1982) · Psychoneuroendocrinology · doi:10.1016/0306-4530(82)90058-0 · Cited by 293
DISTRIBUTION OF OXYTOCIN AND VASOPRESSIN IN THE RAT SUPRAOPTIC AND PARAVENTRICULAR NUCLEUS
Swaab, D. F., Nijveldt, F., & Pool, C. W. (1975) · Journal of Endocrinology · doi:10.1677/joe.0.0670461 · Cited by 254
Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.
Cooper, K., Kasting, N. W., Lederis, K. P., & Veale, W. L. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012953 · Cited by 251
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The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia
Swaab, D. F., Fliers, E., & Partiman, T. S. (1985) · Brain Research · doi:10.1016/0006-8993(85)91350-2 · Cited by 847
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
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Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“…in VP neurons and plasma VP concentrations have also been found in humans (Share et al., 1988; Asplund & Aberg, 1991; Van Londen et al., 1997; Ishinina et al., 1999; Miller et al., 2013; Graugaard-Jensen et al., 2014; however, see Fliers et al., 1985; Swaab et al., 2001; Gouin et al., 2012).”
BackgroundInfluentialPurba, J. S. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020055007 · Cited by 433
Metadata
- Authors
- Fliers, E., Swaab, D. F., W. Pool, C., & Verwer, R. W. H.
- Corresponding author
- Fliers, E.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1985-09
- Volume
- 342
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2029372047
- Cited by
- 190
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 17.96
- Type
- journal article
- Language
- en
- Open access
- green
- pure.knaw.nl
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
- Keywords
- vasopressin, oxytocin, supraoptic nucleus, paraventricular nucleus, hypothalamo-neurohypophysial system, aging, senile dementia, Alzheimer's disease, neuropeptide neurons, cell size, fluid and electrolyte balance
- MeSH terms
- Adolescent, Adult, Aged, Aging, Alzheimer Disease, Arginine Vasopressin, Child, Female, Histocytochemistry, Humans, Immunochemistry, Male, Middle Aged, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Supraoptic Nucleus
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