Cited by 153Neuroendocrine regulation and behaviorSexual Differentiation and DisordersHypothalamic control of reproductive hormones

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Effects of androgens and estrogens on the vasopressin and oxytocin innervation of the adult rat brain

De Vries, Geert J., Duetz, Wouter, Buijs, Ruud M., van Heerikhuize, Joop, Vreeburg, Jan T.M.·1986·Brain Research

DOI 10.1016/0006-8993(86)91519-2

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Abstract

Recently we reported that castration of rats eliminates vasopressin immunoreactivity in the lateral septum and other areas that appear to receive vasopressin innervation from the bed nucleus of the stria terminalis. Testosterone treatment counteracts this effect of castration. In the present study, we investigated whether this action of testosterone depends on its androgenic or estrogenic metabolites by treating long-term castrated rats with estradiol (E) and/or 5 alpha-dihydrotestosterone (DHT) or testosterone. The brains were then processed for immunocytochemistry or radioimmunoassay. DHT did not increase vasopressin staining in the lateral septum, although it fully restored the size of the seminal vesicles. E did restore the original fiber density, but individual fibers stained more weakly than in sham-operated males. Only treatment with both E and DHT fully restored the vasopressin innervation. This pattern was also reflected in the radioimmunoassay data. The vasopressin content of the lateral septum decreased about 90% after castration but was fully restored by either testosterone or E + DHT treatment. E alone, however, was only half as effective as E + DHT. The treatments had no effect on the oxytocin content of the septum, or on the vasopressin or oxytocin content of the dorsal vagal complex. The results suggest that E mediates most of the effects of testosterone on the vasopressin innervation of the lateral septum. DHT enhances the response to E but has little effect on its own.

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Authors: De Vries, G. J., Duetz, W., Buijs, R. M., van Heerikhuize, J., & Vreeburg, J. T. M.
Affiliations: Erasmus University Rotterdam (NL)
ORCID: Buijs, Ruud M.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1986-12
Volume: 399
Issue: 2
Pages: 296-302
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(86)91519-2
OpenAlex: W2041680408
Cited by: 153
References: 64
Citations by year: 2025: 1 · 2024: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
FWCI: 5.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: vasopressin, oxytocin, androgens, estrogen, testosterone, estradiol, dihydrotestosterone, castration, lateral septum, bed nucleus of the stria terminalis, dorsal vagal complex, seminal vesicle, sex hormones
MeSH terms: Animals, Brain, Castration, Estradiol, Male, Oxytocin, Rats, Inbred Strains, Seminal Vesicles, Septum Pellucidum, Dihydrotestosterone, Testosterone, Vasopressins, Rats

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Effects of androgens and estrogens on the vasopressin and oxytocin innervation of the adult rat brain

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