The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Effects of androgens and estrogens on the vasopressin and oxytocin innervation of the adult rat brain
Abstract
Recently we reported that castration of rats eliminates vasopressin immunoreactivity in the lateral septum and other areas that appear to receive vasopressin innervation from the bed nucleus of the stria terminalis. Testosterone treatment counteracts this effect of castration. In the present study, we investigated whether this action of testosterone depends on its androgenic or estrogenic metabolites by treating long-term castrated rats with estradiol (E) and/or 5 alpha-dihydrotestosterone (DHT) or testosterone. The brains were then processed for immunocytochemistry or radioimmunoassay. DHT did not increase vasopressin staining in the lateral septum, although it fully restored the size of the seminal vesicles. E did restore the original fiber density, but individual fibers stained more weakly than in sham-operated males. Only treatment with both E and DHT fully restored the vasopressin innervation. This pattern was also reflected in the radioimmunoassay data. The vasopressin content of the lateral septum decreased about 90% after castration but was fully restored by either testosterone or E + DHT treatment. E alone, however, was only half as effective as E + DHT. The treatments had no effect on the oxytocin content of the septum, or on the vasopressin or oxytocin content of the dorsal vagal complex. The results suggest that E mediates most of the effects of testosterone on the vasopressin innervation of the lateral septum. DHT enhances the response to E but has little effect on its own.
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In the citing paper
“while Sa-dihydrotestosterone (DHT)which is an androgenic, nonaromatizable metabolite of testosterone generated by reduction (Lieberburg and McEwen, 1975)does not by itself restore AVP immunostaining.”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as De Vries et al., 1986
In the citing paper
“However, if DHT is given in combination with E, it enhances AVP immunostaining (De Vries et al., 1986).”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as De Vries et al., 1986
In the citing paper
“Estradiol (E)-which is an estrogenic metabolite of testosterone generated by aromatization (Naftolin et al., 1975)-partially restores AVP immunostaining in castrated male rats”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as De Vries et al., 1986
Citations
Cites
Atlas of estradiol‐concentrating cells in the central nervous system of the female rat
Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
Self-citationSexual differentiation of the brain
McEwen, B. S. (1981) · Nature · doi:10.1038/291610a0 · Cited by 899
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
Self-citationThe Formation of Estrogens by Central Neuroendocrine Tissues
NAFTOLIN, F., RYAN, K. J., DAVIES, I. J., REDDY, V. V., FLORES, F., PETRO, Z., KUHN, M., WHITE, R. J., TAKAOKA, Y., & WOLIN, L. (1975) · Proceedings of the 1974 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571131-9.50012-8 · Cited by 793
Beatty, W. W. (1979) · Hormones and Behavior · doi:10.1016/0018-506x(79)90017-5 · Cited by 631
de Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524
Self-citationThe vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522
Self-citationEndocrine control of sexual behavior.
Beyer, C. (1979) · Raven Press eBooks · Cited by 464
Research works printed but not linked: 2
- So¨dersten, 1984, Role of vasopressin in the diurnal rhythm in sexual behaviour in female rats, Neurosci. Lett., 18, S440
- Van Haaren, F. and Van de Poll, N.E., Multiple passive avoidance in male and female Wistar rats: effects of gonadectomy, shock intensity and administration of testosterone-proprionate to ovariectomized females, Physiol. Behav., in press.
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Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
Goodson, J. L., & Bass, A. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00043-1 · Cited by 646
Arnold, A. P., & Chen, X. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.001 · Cited by 587
Estrogen control of central neurotransmission: Effect on mood, mental state, and memory
Fink, G., SUMNER, B. E. H., Rosie, R., Grace, O., & Quinn, J. P. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02088099 · Cited by 431
De Vries, G. J., & Panzica, G. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.050 · Cited by 346
Metadata
- Authors
- De Vries, G. J., Duetz, W., Buijs, R. M., van Heerikhuize, J., & Vreeburg, J. T. M.
- Affiliations
- Erasmus University Rotterdam (NL)
- ORCID
- Buijs, Ruud M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1986-12
- Volume
- 399
- Issue
- 2
- Pages
- 296-302
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2041680408
- Cited by
- 153
- References
- 64
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- vasopressin, oxytocin, androgens, estrogen, testosterone, estradiol, dihydrotestosterone, castration, lateral septum, bed nucleus of the stria terminalis, dorsal vagal complex, seminal vesicle, sex hormones
- MeSH terms
- Animals, Brain, Castration, Estradiol, Male, Oxytocin, Rats, Inbred Strains, Seminal Vesicles, Septum Pellucidum, Dihydrotestosterone, Testosterone, Vasopressins, Rats
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