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Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia
Abstract
In this study the cellular morphology in the human fascia dentata of 5 very old demented cases (4 Alzheimer's disease and 1 multi-infarct dementia patients) was compared with 5 (very) old controls cases. The postmortem delay in fixation was for all cases within 3.5 h. In the demented group, a significant reduction in thickness of the molecular layer, density of dendritic spines in the middle third of the molecular layer and total dendritic length (+/- 30%) was found. The number of dendritic segments, indicative of the branching frequency showed no difference. In both the control and the demented group, three-quarters of all dendritic bifurcations of granule cells occurred in the inner third of the molecular layer in which the commissural and associational fibers terminate. The size of the dendrites in the demented group could be the result of at least 3 independent processes: a regressive change due to partial denervation of the outer two-thirds of the molecular layer as axons from the perforant pathway are lost; a dendritic regrowth in response to sprouting of the commissural-associational fiber systems and septal afferents, which is presumed to occur in response to degeneration of perforant path axons; a dendritic regrowth in response to the loss of the dendrites of neighboring cells which have died. Analysis of our material suggests that dendritic degeneration is the predominant factor in the demented group.
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Cites
Practical Nonparametric Statistics
Groggel, D. J., & Conover, W. J. (2000) · Technometrics · doi:10.2307/1271101 · Cited by 11,076
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
Practical Non-Parametric Statistics.
Brown, B. M., & Conover, W. J. (1981) · Biometrics · doi:10.2307/2530578 · Cited by 2,412
The Hippocampus as a Cognitive Map
Ranck, J. B. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.10.1353 · Cited by 2,373
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Gundersen, H. J. G. (1986) · PubMed · Cited by 1,658
Practical Nonparametric Statistics
Conover, W. J. (1971) · Cited by 1,477
Stereology of arbitrary particles*
Gundersen, H. J. G. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb02764.x · Cited by 1,444
Pathological verification of ischemic score in differentiation of dementias
Rosen, W. G., Terry, R. D., Fuld, P. A., Katzman, R., & Peck, A. (1980) · Annals of Neurology · doi:10.1002/ana.410070516 · Cited by 1,273
Mishkin, M. (1982) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1982.0074 · Cited by 1,129
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801
Ball, M. J. (1977) · Acta Neuropathologica · doi:10.1007/bf00692056 · Cited by 639
The Human Central Nervous System: A Synopsis and Atlas
Nieuwenhuys, R., Voogd, J., & van Huijzen, C. (2012) · Medical Entomology and Zoology · Cited by 540
The impact of recent stereological advances on quantitative studies of the nervous system
Brændgaard, H., & Gundersen, H. J. G. (1986) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(86)90112-3 · Cited by 501
Plasticity of Hippocampal Circuitry in Alzheimer's Disease
Geddes, J. W., Monaghan, D. T., Cotman, C. W., Lott, I. T., Kim, R. C., & Chui, H. C. (1985) · Science · doi:10.1126/science.4071042 · Cited by 461
The Human Central Nervous System: A Synopsis and Atlas
Clayman, C. Β. (1979) · JAMA · doi:10.1001/jama.1979.03300140055030 · Cited by 331
Penfield, W. G. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490390027001 · Cited by 327
Ribak, C. E., & Seress, L. (1983) · Journal of Neurocytology · doi:10.1007/bf01181525 · Cited by 314
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90129-7 · Cited by 240
van den Berg, L., Hughes, C. P., Coben, L. A., Danziger, W. L., Martin, R. L., & Knesevich, J. W. (1982) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.45.11.962 · Cited by 233
Buell, S. J., & Coleman, P. D. (1981) · Brain Research · doi:10.1016/0006-8993(81)90436-4 · Cited by 220
The metric analysis of three-dimensional dendritic tree patterns: a methodological review
Uylings, H. B. M., Ruiz‐Marcos, A., & van Pelt, J. (1986) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(86)90116-0 · Cited by 187
Self-citationUylings, H. B. M., van Eden, C. G., & Hofman, M. A. (1986) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(86)90111-1 · Cited by 178
Self-citationDendritic extent in human dentate gyrus granule cells in normal aging and senile dementia
Flood, D. G., Buell, S. J., Horwitz, G. J., & Coleman, P. D. (1987) · Brain Research · doi:10.1016/0006-8993(87)90027-8 · Cited by 164
Granule cell dendritic spine density in the rat hippocampus varies with spine shape and location
Desmond, N. L., & Levy, W. B. (1985) · Neuroscience Letters · doi:10.1016/s0304-3940(85)80082-3 · Cited by 140
Physiology and Pathology of Dendrites
Kreutzberg, G. W. (1975) · Medical Entomology and Zoology · Cited by 140
Williams, R. S., Ferrante, R. J., & Caviness, V. S. (1978) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197801000-00002 · Cited by 131
Flood, D. G., Buell, S. J., Defiore, C. H., Horwitz, G. J., & Coleman, P. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)91018-2 · Cited by 111
Chapter 14 Dendritic proliferation in the aging brain as a compensatory repair mechanism
Coleman, P. D., & Flood, D. G. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)64307-1 · Cited by 91
Ordering methods in quantitative analysis of branching structures of dendritic trees.
Uylings, H. B. M., Smit, G. J., & Veltman, W. A. M. (1975) · PubMed · Cited by 89
Self-citationChapter 4 Dendritic Growth and The Control of Neuronal Form
Berry, M., McConnell, P., & Sievers, J. (1980) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60117-9 · Cited by 85
Golgi-Cox and Rapid Golgi Methods as Applied to Autopsied Human Brain Tissue
Buell, S. J. (1982) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198209000-00003 · Cited by 78
Dementia of the Alzheimer Type and Multi‐infarct Dementia
Bucht, G., Adolfsson, R., & Winblad, B. G. (1984) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1984.tb02233.x · Cited by 70
Diseases presenting as dementia.
Haase, G. R. (1971) · PubMed · Cited by 65
Neural Systems of the Non‐human Primate Forebrain Implicated in Memorya
Hoesen, G. W. V. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb37582.x · Cited by 64
Overdijk, J., Uylings, H. B. M., Kuypers, K., & Kamstra, A. W. (1978) · Journal of Microscopy · doi:10.1111/j.1365-2818.1978.tb00137.x · Cited by 54
Self-citationChapter 20 Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease
Hoesen, G. W. V., Hyman, B. T., & Damásio, A. R. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)64313-7 · Cited by 54
Artifactual displacement of neuronal nucleoli in paraffin sections.
Cammermeyer, J. (1967) · PubMed · Cited by 45
Chapter 4 Age-related changes in Down syndrome brain and the cellular pathology of Alzheimer disease
Williams, R. S., & Matthysse, S. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)64297-1 · Cited by 40
The influence of post-mortem fixation delay on the reliability of the Golgi silver impregnation
de Ruiter, J. P. (1983) · Brain Research · doi:10.1016/0006-8993(83)91317-3 · Cited by 36
Advances in the morphology of cells and tissues
Vidrio, E. A., & Galina, M. A. (1981) · A.R. Liss eBooks · Cited by 36
Quantitative analysis of dendritic branching pattern of granular cells from human dentate gyrus
Lindsay, R. D., & Scheibel, A. B. (1976) · Experimental Neurology · doi:10.1016/0014-4886(76)90173-4 · Cited by 34
Basal lamina at the site of spinal cord injury in normal, immunotolerant and immunosuppressed rats
Feringa, E. R., Kowalski, T. F., & Vahlsing, H. L. (1985) · Neuroscience Letters · doi:10.1016/s0304-3940(85)80083-5 · Cited by 11
Morphometry of cortical dendrites.
Uylings, H. B. M., Parnavelas, J. G., & Walg, H. L. (1981) · PubMed · Cited by 7
Self-citation
Cited by
Sorted by citations
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772
Sousa, N., Lukoyanov, N. V., Madeira, M. D., Almeida, O. F. X., & Paula-Barbosa, M. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00050-6 · Cited by 758
Apolipoprotein E in animal models of CNS injury and in alzheimer's disease
Poirier, J. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90156-2 · Cited by 637
Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J., & Hyman, B. T. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1879-05.2005 · Cited by 550
Metadata
- Authors
- de Ruiter, J. P., & Uylings, H. B. M.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Uylings, H.B.M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1987-02
- Volume
- 402
- Issue
- 2
- Pages
- 217-229
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2037846982
- Cited by
- 141
- References
- 47
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- dentate gyrus, granule cells, dendritic morphology, dendritic spines, molecular layer thickness, dendritic degeneration, aging, senile dementia, Alzheimer's disease, multi-infarct dementia, perforant path, dendritic branching
- MeSH terms
- Aged, Aging, Cell Count, Dementia, Dendrites, Granulocytes, Hippocampus, Humans
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