Distribution of choline acetyltransferase-containing neurons of the hypothalamus
Abstract
A system of small to medium size choline acetyltransferase (ChAT)-containing neurons has been identified in rat, monkey and human hypothalamus. A highly sensitive polyclonal anti-human placental ChAT rabbit serum, combined with a nickel ammonium sulfate second antibody intensification method, was used to identify these relatively weakly staining ChAT-positive neurons. The most prominent hypothalamic group consisted of small neurons in the infundibular (arcuate) nucleus. Fibers extended towards the infundibulum. Other ChAT-positive cells were not identified with specific hypothalamic nuclei but were scattered loosely in the surrounding matrix. They fell into two broad complexes: a medially distributed one close to the third ventricle and running rostrocaudal to caudoventral; and a lateral one distributed principally in the region of the medial forebrain bundle. The most laterally placed hypothalamic ChAT-positive neurons slightly overlapped with the large, intensely staining cells of the medial basal forebrain cholinergic complex. The identification of these cells helps to account for previous biochemical and pharmacological studies which have strongly indicated the presence of intrinsic cholinergic neurons in the hypothalamus.
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There are intrinsic neurons within the hypothalamus that express cholinergic markers.
“There are also intrinsic neurons within the hypothalamus that express cholinergic markers (Tago et al., 1987)”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Tago et al., 1987
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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
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- Authors
- Tago, H., McGeer, P. L., Bruce, G., & Hersh, L. B.
- Affiliations
- University of British Columbia (CA)
- University of Texas Health Science Center at Dallas (US)
- Corresponding author
- McGeer, P.L.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1987-07
- Volume
- 415
- Issue
- 1
- Pages
- 49-62
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2090093798
- Cited by
- 142
- References
- 22
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-05893)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- choline acetyltransferase, hypothalamus, cholinergic neurons, arcuate nucleus, medial forebrain bundle, third ventricle, neuronal distribution, rats, monkeys, human
- MeSH terms
- Animals, Brain Mapping, Choline O-Acetyltransferase, Cholinergic Fibers, Histocytochemistry, Humans, Hypothalamus, Immunoenzyme Techniques, Macaca mulatta, Rats
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