Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype
Open accessAbstract
Neuronal networks originating in the hypothalamic arcuate nucleus play fundamental roles in the control of energy balance. Neuropeptide Y (NPY)-producing neurons in the arcuate nucleus stimulate food intake, whereas arcuate nucleus neurons that release the proopiomelanocortin (POMC)-derived peptide alpha-melanocyte-stimulating hormone (alpha-MSH) potently reduce food intake. Relatively little attention has been focused on classical neurotransmitters in regulation of food intake. Here, we have investigated the potential presence of acetylcholine (ACh) in NPY- and POMC-containing neuronal populations of the arcuate nucleus. Antisera to proteins required for cholinergic neurotransmission, including choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT), were employed in double-labeling immunohistochemical experiments. In colchicine-treated rats, ChAT- and VAChT-immunopositive cell bodies were located in the ventral aspect of the arcuate nucleus. ChAT and VAChT immunoreactivities were demonstrated in alpha-MSH- and cocaine- and amphetamine-regulated transcript (CART)-containing cell bodies of the arcuate nucleus, whereas cell bodies containing NPY or agouti-related peptide (AGRP) were distinct from VAChT-immunoreactive neuronal perikarya. VAChT immunoreactivity was also present in a large number of alpha-MSH-containing nerve fiber varicosities throughout the central nervous system. In the commissural part of the nucleus tractus solitarius, no alpha-MSH-containing cell bodies were found to have ChAT or VAChT immunoreactivity. The presence of markers for cholinergic neurotransmission in a subpopulation of hypothalamic POMC/CART neurons suggests co-release of ACh with peptides derived from the POMC precursor and CART. The results indicate a role for ACh in control of energy balance, mediating the effects of peripheral hormones such as leptin and insulin.
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There are intrinsic neurons within the hypothalamus that express the POMC peptide.
“as well as the pro-opiomelanocortin (POMC) peptide (Meister et al., 2006)”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Meister et al., 2006
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- Authors
- Meister, B., Gömüç, B., Suarez, E., Ishii, Y., Dürr, K., & Gillberg, L.
- Affiliations
- Karolinska Institutet (SE)
- ORCID
- Meister, Björn
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-11
- Volume
- 24
- Issue
- 10
- Pages
- 2731-2740
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2155819491
- Cited by
- 75
- References
- 56
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet (72X-10358)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- proopiomelanocortin neurons, hypothalamic arcuate nucleus, cholinergic neurotransmission, acetylcholine, choline acetyltransferase, vesicular acetylcholine transporter, alpha-melanocyte-stimulating hormone, cocaine- and amphetamine-regulated transcript, neuropeptide Y, agouti-related protein, food intake regulation, energy balance, leptin, insulin, nucleus tractus solitarius
- MeSH terms
- Cocaine- and Amphetamine-Regulated Transcript Protein, Acetylcholine, Animals, Choline O-Acetyltransferase, Hypothalamus, Immunohistochemistry, Male, Nerve Tissue Proteins, Neurons, Neuropeptide Y, Phenotype, Pro-Opiomelanocortin, Rats, Sprague-Dawley, In Situ Hybridization, Microscopy, Confocal, Vesicular Acetylcholine Transport Proteins, Rats
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