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Cited by 166Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorPharmacological Receptor Mechanisms and Effects

Motivational properties of opioids: evidence that an activation of σ-receptors mediates reinforcement processes

Shippenberg, T.S., Bals-Kubik, R., Herz, A.·1987·Brain Research
DOI 10.1016/0006-8993(87)91667-2
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Abstract

The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-25.0 micrograms) produced a significant preference for the drug-associated place and a similar effect was observed following i.c.v. injections of morphine (10.0 micrograms). Administration of the delta-receptor antagonist, ICI 174,864, at doses (1.0-5.0 micrograms, i.c.v.) which had no aversive effects when tested alone, abolished the reinforcing properties of DPDPE. Such treatment did not, however, modify the effect of morphine. These findings demonstrate the involvement delta- as well as mu-receptors in the motivational properties of opioids and suggest that the activation of either receptor type is sufficient for the elicitation of appetitively reinforcing effects.

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  • Based on animal studies, the role of opioids in the positive reinforcing effects of natural rewards and drugs of abuse has largely been attributed to MOR in the nucleus accumbens, ventral pallidum, and VTA, though some part is also played by DOR.

    “Based on animal studies, the role of opioids in the positive reinforcing effects of natural rewards and drugs of abuse has largely been attributed to MOR in the NAC, VP, and VTA, though some part is also played by DOR (van Ree and de Wied 1980; Shippenberg et al 1987; Hubner and Koob 1990; Olmstead and Franklin 1997a; Corrigall et al 2000; Pecina and Berridge 2000; Van Ree et al 2000; Gerrits et”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Shippenberg et al 1987

  • MOR and DOR mediate generally positive motivation and affect, while KOR mediates generally negative motivation and aversion.

    “Nonetheless, the three receptor types have different behavioral domains, with MOR and DOR mediating generally positive motivation and affect, while KOR mediates generally negative motivation and aversion (Pfeiffer et al 1986; Shippenberg et al 1987; Pecina and Berridge 2000; McLaughlin et al 2003; for reviews see Van Ree et al 2000; Le Merrer et al 2009).”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Shippenberg et al 1987

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Authors
Shippenberg, T. S., Bals-Kubik, R., & Herz, A.
Affiliations
Max Planck Institute of Psychiatry (DE)
Corresponding author
Shippenberg, T.S.
Venue
Brain Research
Publisher
Elsevier BV
Published
1987-12
Volume
436
Issue
2
Pages
234-239
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(87)91667-2
OpenAlex
W2084913220
Cited by
166
References
22
Citations by year
2025: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 5
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
Keywords
delta opioid receptor, opioid reinforcement, place preference, morphine, DPDPE, ICI 174,864, mu-opioid receptor, intracerebroventricular administration
MeSH terms
Animals, Appetitive Behavior, Avoidance Learning, Enkephalin, Leucine, Enkephalins, Injections, Intraventricular, Male, Morphine, Motivation, Rats, Inbred Strains, Receptors, Opioid, Reinforcement, Psychology, Receptors, Opioid, delta, Enkephalin, D-Penicillamine (2,5)-, Rats

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