Morphological differences between projection neurons of the core and shell in the nucleus accumbens of the rat

Meredith, G.E.; Agolia, R.; Arts, M.P.M.; Groenewegen, H.J.; Zahm, D.S.

doi:10.1016/0306-4522(92)90389-j

Cited by 231Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatments

Morphological differences between projection neurons of the core and shell in the nucleus accumbens of the rat

Meredith, G.E., Agolia, R., Arts, M.P.M., Groenewegen, H.J., Zahm, D.S.·1992·Neuroscience

DOI 10.1016/0306-4522(92)90389-j

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Abstract

The somatodendritic morphology of projection neurons in the shell and core of the rat nucleus accumbens was studied. These cells were retrogradely labelled with Fast Blue from the ventral mesencephalon (substantia nigra/ventral tegmental area) and subsequently injected intracellularly with Lucifer Yellow and processed immunocytochemically. Digitized reconstructions revealed that the cell bodies of neurons located throughout the nucleus are small-to-medium in size. Neurons in the shell have significantly fewer dendritic arbours with fewer branch segments, fewer terminal segments, and lower spine densities than those in the core. Values for the same parameters are significantly greater for cells in lateral than in medial parts of the shell but the same for neurons located within and without enkephalin enriched parts of the core, with an exception of spine density being significantly greater in the enkephalin-rich compartment. Calculations based on these data reveal that neurons in the core have as much as 50% more surface area than those in the shell, which suggests that core neurons have a greater potential for collecting synaptic information than have shell cells. Furthermore, the differential distribution and action of various neurochemicals such as dopamine in the shell and core, supports the idea that different morphologies reflect the presence of distinct neuronal circuits in these two territories.

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Features such as spine density and terminal and branch segments appear to differ between the medial shell and the lateral shell, and between the shell and the core.
“Features such as spine density and terminal and branch segments appear to differ between the medial shell and the lateral shell, and between the shell and the core (Meredith et al., 1992; 1995).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Meredith et al., 1992

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Bayassi-Jakowicka, M., Lietzau, G., Czuba, E., Steliga, A., Waśkow, M., & Kowiański, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189806 · Cited by 43 · see citing works

Authors: Meredith, G. E., Agolia, R., Arts, M. P. M., Groenewegen, H. J., & Zahm, D. S.
Affiliations: Vrije Universiteit Amsterdam (NL)
Saint Louis University (US)
Corresponding author: Meredith, G.E.
ORCID: Groenewegen, H.J.
Zahm, D.S.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1992-09
Volume: 50
Issue: 1
Pages: 149-162
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(92)90389-j
OpenAlex: W2083738090
Cited by: 231
References: 74
Citations by year: 2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 5
FWCI: 3.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS23805, R01NS023805)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords: nucleus accumbens, projection neurons, dendritic morphology, dendritic spines, enkephalin, substantia nigra, ventral tegmental area, dopamine, neural circuits, synaptic input
MeSH terms: Amidines, Animals, Axonal Transport, Corpus Striatum, Dendrites, Enkephalin, Leucine, Female, Fluorescent Dyes, Golgi Apparatus, Horseradish Peroxidase, Isoquinolines, Mesencephalon, Neurons, Nucleus Accumbens, Rats, Wistar, Rats

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Morphological differences between projection neurons of the core and shell in the nucleus accumbens of the rat

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