Cited by 98Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Effects of interleukin-1beta polymorphisms on brain function and behavior in healthy and psychiatric disease conditions

Tsai, Shih-Jen·2017·Cytokine & Growth Factor Reviews

Abstract

A high level of Interleukin-1beta (IL1B), a key mediator of inflammation, is expressed in the brain, particularly in the hippocampus, which plays a pivotal role in memory and mood regulation. In the brain, IL1B exerts a myriad of effects such as neuronal proliferation, differentiation, apoptosis, and long-term potentiation. Considering its pleiotropic effects in the brain, IL1B has been implicated in the pathogenesis of various psychiatric disorders as well as cognitive function in normal individuals. Thus, IL1B has been considered a candidate gene for the study of psychiatric diseases as well as brain function in normal individuals. The polymorphisms of IL1B have been described in relation to various expression levels in response to stimulation. This review describes previous studies on the genetic effects of IL1B, which relate it to psychiatric diseases such as major depressive disorder, bipolar disorder, schizophrenia, and Alzheimer's disease, as well as cognitive function in normal individuals. Although many reports have indicated a possible role of the genetic effects of IL1B or its phenotypes in psychiatric diseases, some reports were unable to confirm these findings. IL1B release is mediated by an inflammatory response or psychological stress, leading to a cascade of immune reactions involving numerous immune components. To further explore the genetic effects of IL1B on mental diseases and brain function, gene-gene and gene-environment interactions should also be considered.

Integrity signals

Registry

Crossref · 10.1016/j.cytogfr.2017.06.001

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

3 of the 125 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Tsai, S.-J.
Affiliations
Taipei Veterans General Hospital (TW)
Corresponding author
Tsai, Shih-Jen
Venue
Cytokine & Growth Factor Reviews
Publisher
Elsevier BV
Published
2017-10
Volume
37
Pages
89-97
ISSN
1359-6101 (ISSN-L)
OpenAlex
W2620755913
Cited by
98
References
125
Citations by year
2026: 13 · 2025: 10 · 2024: 12 · 2023: 9 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 4
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Locations
  • Cytokine & Growth Factor Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • MOST (103-2314-B-075-067-MY3)
  • Taiwan Ministry of Science and Technology (V105E17-002-MY2-1, V105C-008, VGHUST103-G1-4-1)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
IL-1β, genetic susceptibility, mental illness, major depressive disorder, bipolar disorder, schizophrenia, Alzheimer's disease, cognitive function, hippocampus, neuroinflammation, psychological stress, gene-environment interaction, gene-gene interaction
MeSH terms
Adult, Alleles, Animals, Mental Disorders, Brain, Depressive Disorder, Major, Major Depressive Disorder, Genotype, Humans, Schizophrenia, Mood Disorders, Polymorphism, Single Nucleotide, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review