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Cited by 33Neuroscience and Neuropharmacology ResearchPain Mechanisms and TreatmentsMemory and Neural Mechanisms

Cortically projecting cells in the periaqueductal gray matter of the rat. A retrograde fluorescent tracer study

Herrero, M.T., Insausti, R., Gonzalo, L.M.·1991·Brain Research
DOI 10.1016/0006-8993(91)90029-u
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Abstract

The topographical organization of the afferent input from the periaqueductal gray matter (PAG) to the cerebral cortex has been assessed in rats by retrograde transport of the fluorescent tracers Fast blue (FB) and Diamidino yellow (DY). The olfactory, medial frontal (infralimbic, prelimbic and anterior cingulate cortices), lateral frontal (motor), parietal, temporal, occipital and insular cortices were explored by placing two fluorescent tracers into two different cortical regions. The PAG contained the largest number of labeled neurons in medial frontal cortex injections, followed by olfactory and lateral frontal cortices. Fewer retrogradely labeled cells were seen after injections in parietal, temporal occipital and insular cortices. All labeled cells were exclusively located in the medial and lateroventral divisions of the PAG (PAGm and PAGlv). The longitudinal extent of the labeling in PAGm was more extensive than in PAGlv. The labeled neurons in the medial frontal cortex group extended through most of the PAG, while in the remaining groups it was restricted to the caudal one-third of the PAG. Neurons with projections to two different cortical regions were only a small fraction of the total population of labeled cells. Our data indicate that the medial frontal cortex is the most important recipient of a direct PAG input, followed by the lateral frontal cortex. Parietal, temporal, occipital and insular cortices receive only a minor projection. It is concluded that the PAG sends direct projections over the majority of the cortical mantle. Therefore, the possibility arises that the cerebral cortex receives a direct influence from the brainstem without a thalamic relay.

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  • The periaqueductal gray sends monosynaptic reciprocal projections to ventromedial prefrontal cortex and to anterior mid-cingulate cortex, orbitofrontal cortex, and other areas involved in action value and defensive behavior.

    “It also sends monosynaptic, reciprocal projections to the vmPFC—which is essential for value updating in the RL framework and likely for behavioral choice as well31—and to aMCC32, OFC and other areas involved in determining action value and coordinating defensive behavior18,33.”

    From Representation of aversive prediction errors in the human periaqueductal gray (2014) · cites this paper as [32]

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Authors
Herrero, M. T., Insausti, R., & Gonzalo, L. M.
Affiliations
Universidad de Navarra (ES)
Corresponding author
  • Herrero, M.T.
  • Insausti, R.
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
1991-03
Volume
543
Issue
2
Pages
201-212
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(91)90029-u
OpenAlex
W2058048052
Cited by
33
References
51
Citations by year
2026: 1 · 2024: 4 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
periaqueductal gray, corticopontine projections, medial frontal cortex, olfactory cortex, lateral frontal cortex, parietal cortex, temporal cortex, occipital cortex, insula, Fast Blue, Diamidino Yellow, retrograde tracing
MeSH terms
Animals, Cerebral Cortex, Female, Fluorescent Dyes, Frontal Lobe, Male, Occipital Lobe, Olfactory Bulb, Parietal Lobe, Periaqueductal Gray, Rats, Inbred Strains, Temporal Lobe, Rats

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