Cited by 391Memory and Neural MechanismsMemory Processes and InfluencesCognitive Functions and Memory

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A two-trial memory task with automated recording: study in young and aged rats

Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., Simon, H.·1992·Brain Research

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Abstract

A two-trial recognition task, based on place or object exploration in a Y-maze, was developed to study memory in adult and aged rats. This paradigm avoids the use of electric shocks or deprivation that may have non-specific influences on the responses, and the task does not require learning of a rule. A number of behavioral parameters in several animals could be recorded automatically. These behavioral parameters were found to be differently influenced both by the type of recognition (place vs. object) and by the inter-trial interval (recognition retention time). Impaired recognition was also detected in 18-months-old rats. This recognition task which combines simplicity, sensitivity and high specificity may thus be a useful adjunct to our current battery of memory tasks.

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Authors: Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., & Simon, H.
Affiliations: Université de Bordeaux (FR)
Corresponding author: Simon, H.
ORCID: Mayo, W.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1992-08
Volume: 588
Issue: 1
Pages: 132-139
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(92)91352-f
OpenAlex: W1984139645
Cited by: 390
References: 20
Citations by year: 2026: 17 · 2025: 14 · 2024: 13 · 2023: 17 · 2022: 16 · 2021: 14 · 2020: 15 · 2019: 15 · 2018: 19 · 2017: 17 · 2016: 21 · 2015: 17 · 2014: 24 · 2013: 22 · 2012: 12
FWCI: 1.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords: recognition memory, Y-maze, place recognition, object recognition, aging, aged rats, memory impairment, intertrial interval
MeSH terms: Aging, Animals, Discrimination, Psychological, Exploratory Behavior, Male, Memory, Rats, Sprague-Dawley, Rats

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A two-trial memory task with automated recording: study in young and aged rats

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