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Cited by 66Heart Rate Variability and Autonomic ControlNeuroscience of respiration and sleepCardiovascular Syncope and Autonomic Disorders

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Cardiac baroreflex dynamics during the defence reaction in freely moving rats

Schenberg, Luiz Carlos, Corral Vasquez, Elisardo, Barcellos da Costa, Mércia·1993·Brain Research
DOI 10.1016/0006-8993(93)90296-y
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Abstract

To determine the extent of baroreceptor reflex involvement in the cardiovascular changes observed during electrically induced defence reaction, the mean arterial blood pressure (MBP) and heart rate (HR) of conscious intact or sinoaortic baroreceptor denervated (SAD) rats were continuously recorded from indwelling cannulae during a 1-min period of electrical stimulation of the mesencephalic tectum. Electrical stimulation produced stimulus intensity-dependent behaviours including freezing at lower intensities and flight at higher intensities. The cardiovascular responses in intact rats were dependent on both the intensity and duration of the stimulus. A linear increase in MBP was observed with increasing stimulus intensities. However, while a slight bradycardia was observed during the freezing behaviour, a marked tachycardia occurred during flight. Simultaneous increases of MBP and HR were seen throughout the first 15 s of the flight response, after which the HR rapidly fell to baseline levels, whereas the MBP remained at a hypertensive plateau until the end of the stimulus. The baroreflex HR curve showed a parallel shift to the left during the first half of the freezing period, being fully reset 40 s after that. So, while the baroreflex gain remained unchanged, the reflex set point was lowered during the freezing stage of the defence reaction. The experiments with SAD rats corroborated the above data. The baroreceptor denervation reversed the freezing bradycardia to tachycardia. Moreover, the denervation potentiated the flight tachycardia and prevented its later reset. MBP responses of baroreceptor denervated rats did not differ from the sham-operated group. The sustained hypertension, thus, appears to be mediated by mechanisms other than the mere baroreceptor reflex deactivation. (ABSTRACT TRUNCATED AT 250 WORDS)

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Research works printed but not linked: 4

  1. Azevedo, 1979, The defence reaction elicited by midbrain and hypothalamic stimulation in the rabbit, J. Physiol., 301, 56
  2. Folkow, 1987, Physiology of behavior and blood pressure regulation in animals, Vol. 9, 1
  3. Hilton, 1963, Inhibition of baroreceptor reflexes on hypothalamic stimulation, J. Physiol., 165, 56
  4. Schneiderman, 1987, Physiology of behavior and blood pressure regulation in humans, Vol. 9, 19

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Metadata

Authors
Schenberg, L. C., Corral Vasquez, E., & Barcellos da Costa, M.
Affiliations
Universidade Federal do Espírito Santo (BR)
Corresponding author
Schenberg, Luiz Carlos
ORCID
Schenberg, Luiz Carlos
Venue
Brain Research
Publisher
Elsevier BV
Published
1993-09
Volume
621
Issue
1
Pages
50-58
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(93)90296-y
OpenAlex
W1990784699
Cited by
66
References
47
Citations by year
2026: 2 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 2
FWCI
0.95
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Keywords
baroreflex, defense response, mean arterial pressure, heart rate, freezing behavior, escape behavior, baroreflex gain, sustained hypertension, tachycardia, bradycardia
MeSH terms
Aggression, Animals, Aorta, Blood Pressure, Denervation, Electric Stimulation, Electrodes, Heart Rate, Male, Movement, Rats, Wistar, Baroreflex, Rats

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