Long-lasting marked inhibition of periaqueductal gray-evoked defensive behaviors in inescapably-shocked rats

Quintino‐dos‐Santos, Jeyce W.; Müller, Cláudia J. T.; C. Santos, Alexandre M.; Tufik, Sérgio; Rosa, Caroline A.; Schenberg, Luiz C.

doi:10.1111/ejn.12410

Cited by 7Stress Responses and CortisolMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Long-lasting marked inhibition of periaqueductal gray-evoked defensive behaviors in inescapably-shocked rats

Quintino‐dos‐Santos, Jeyce W., Müller, Cláudia J. T., C. Santos, Alexandre M., Tufik, Sérgio, Rosa, Caroline A., Schenberg, Luiz C.·2014·European Journal of Neuroscience

DOI 10.1111/ejn.12410

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Abstract

Clinical evidence suggests that depression and trauma predispose the subject to panic. Accordingly, here we examined the late effects of uncontrollable stress, a presumptive model of depression and/or traumatic disorder, on panic‐like behaviors evoked by electrical stimulation of the dorsal periaqueductal gray (DPAG). Changes in anxiety and depression were also assessed in the elevated plus‐maze (EPM) and forced‐swimming test (FST), respectively. Rats with electrodes in the DPAG were subjected to a 7‐day shuttle‐box one‐way escape yoked training with foot‐shocks either escapable (ES) or inescapable (IS). The day after the end of one‐way escape training, rats were trained in a two‐way escape novel task (test‐session) to ascertain the effectiveness of uncontrollable stress. DPAG stimulations were carried out in an open field, both before the escape training and 2 and 7 days after it, and EPM and FST were performed on the 8th and 10th days afterwards, respectively. Controls were either trained with fictive shocks (FS) or subjected to intracranial stimulations only. Although the ES rats performed significantly better than the IS group in the two‐way escape task, groups did not differ with respect to either the anxiety or depression scores. Unexpectedly, however, IS rats showed a marked attenuation of DPAG‐evoked freezing and flight behaviors relative to both the ES and FS groups, 2 and 7 days after one‐way escape training. The conjoint inhibition of passive (freezing) and active (flight) defensive behaviors suggests that IS inhibits a DPAG in‐built motivational system that may be implicated in depressed patients' difficulties in coping with daily‐life stress.

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The increased periaqueductal gray volume suggests differences in fear and panic responses between susceptible and resilient mice.
“pointing toward differences in fear and panic responses between susceptible and resilient mice (43,44,59).”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [44]

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Dorsal periaqueductal gray stimulation facilitates anxiety-, but not panic-related, defensive responses in rats tested in the elevated T-maze
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Prior electrical stimulation of dorsal periaqueductal grey matter or deep layers of the superior colliculus sensitizes rats to anxiety-like behaviors in the elevated T-maze test
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Authors: Quintino‐dos‐Santos, J. W., Müller, C. J. T., C. Santos, A. M., Tufik, S., Rosa, C. A., & Schenberg, L. C.
Affiliations: Department of Physiological Sciences Federal University of Espírito Santo Vitória Brazil
Universidade Federal do Espírito Santo (BR)
Universidade Federal de São Paulo (BR)
Corresponding author: Schenberg, Luiz C.
ORCID: Müller, Cláudia J. T.
Tufik, Sérgio
Rosa, Caroline A.
Schenberg, Luiz C.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2013-11-04
Volume: 39
Issue: 2
Pages: 275-286
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/ejn.12410
OpenAlex: W2017388204
Cited by: 7
References: 108
Citations by year: 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2
FWCI: 0.60
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders: Deakin University
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: dorsal periaqueductal gray, inescapable shock, uncontrollable stress, defensive behavior, freezing behavior, flight behavior, panic-like behavior, depression, anxiety, escape learning, stress coping, trauma, electrical stimulation
MeSH terms: Animals, Anxiety Disorders, Depressive Disorder, Electrodes, Implanted, Electroshock, Escape Reaction, Male, Motor Activity, Neuropsychological Tests, Panic, Periaqueductal Gray, Stress, Psychological, Rats, Wistar, Rats

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Long-lasting marked inhibition of periaqueductal gray-evoked defensive behaviors in inescapably-shocked rats

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