The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus
Open accessAbstract
Using in situ hybridization histochemistry, we report differential expression of corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA) and the parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following systemic treatment with corticosterone (CORT) in adrenally-intact rats. Both injection of low (1 mg/kg/day) and high (5 mg/day) CORT reduced CRH mRNA expression in the PVN in a dose-dependent manner, although it returned to normal at the low dose by 14 days. By contrast, the high dose of CORT increased CRH mRNA transiently in the CEA at 4 days, although the low dose of CORT decreased it at 14 days. In a second experiment, we implanted a slowly-releasing CORT pellet for 2 weeks (200 mg, 60 day release) subcutaneously. This treatment produced an elevation of CRH mRNA in the CEA both at 1 and 2 weeks, whereas CRH mRNA in the PVN was decreased to a large extent as seen in the high CORT group of the first experiment. These results suggest that glucocorticoids can facilitate CRH mRNA expression in the CEA, a site implicated in anxiety and fear, while restraining the hypothalamic-pituitary-adrenal axis as indicated by the reduction in CRH mRNA in the PVN.
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“previous studies have shown that chronic corticosterone administration upregulates the CRF mRNA level in CeAL and BNSTL neurons (Liu et al, 2004; Makino et al, 1994a, b; Shepard et al, 2000; Swanson and Simmons, 1989; Watts and Sanchez-Watts, 1995) and interacts synergistically with CRF to increase startle amplitude (Lee et al, 1994).”
From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Makino et al, 1994a, b
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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
Clinical and Biochemical Manifestations of Depression
Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190706 · Cited by 1,057
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Research works printed but not linked: 2
- Makino, 1993, Corticosterone effects on CRH mRNA in the parvocellular PVN and the central nucleus of the amygdala, Soc. Neurosci. Abstr.
- Pich, 1992, Stress-Induced Release of Corticotropin-Releasing Factor in the Amygdala measured by in vivo dialysis, Soc. Neurosci. Abstr.
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Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c150015 · Cited by 1,819
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Metadata
- Authors
- Makino, S., Gold, P. W., & Schulkin, J.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Schulkin, Jay
- ORCID
- Schulkin, Jay
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 640
- Issue
- 1-2
- Pages
- 105-112
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2076200184
- Cited by
- 400
- References
- 40
- Citations by year
- 2026: 8 · 2025: 1 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 13 · 2019: 4 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 16
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- corticosterone, corticotropin-releasing factor, CRH mRNA expression, central amygdala, paraventricular nucleus, glucocorticoids, hypothalamic-pituitary-adrenal axis, dose-dependent effects, fear and anxiety
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Amygdala, Animals, Autoradiography, Corticosterone, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Male, Organ Size, Paraventricular Hypothalamic Nucleus, RNA, Messenger, Thymus Gland, Rats, Sprague-Dawley, In Situ Hybridization, Rats
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