Cited by 400Stress Responses and CortisolNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

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Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus

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Makino, Shinya, Gold, Phillip W., Schulkin, Jay·1994·Brain Research

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Abstract

Using in situ hybridization histochemistry, we report differential expression of corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA) and the parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following systemic treatment with corticosterone (CORT) in adrenally-intact rats. Both injection of low (1 mg/kg/day) and high (5 mg/day) CORT reduced CRH mRNA expression in the PVN in a dose-dependent manner, although it returned to normal at the low dose by 14 days. By contrast, the high dose of CORT increased CRH mRNA transiently in the CEA at 4 days, although the low dose of CORT decreased it at 14 days. In a second experiment, we implanted a slowly-releasing CORT pellet for 2 weeks (200 mg, 60 day release) subcutaneously. This treatment produced an elevation of CRH mRNA in the CEA both at 1 and 2 weeks, whereas CRH mRNA in the PVN was decreased to a large extent as seen in the high CORT group of the first experiment. These results suggest that glucocorticoids can facilitate CRH mRNA expression in the CEA, a site implicated in anxiety and fear, while restraining the hypothalamic-pituitary-adrenal axis as indicated by the reduction in CRH mRNA in the PVN.

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Makino, 1993, Corticosterone effects on CRH mRNA in the parvocellular PVN and the central nucleus of the amygdala, Soc. Neurosci. Abstr.
Pich, 1992, Stress-Induced Release of Corticotropin-Releasing Factor in the Amygdala measured by in vivo dialysis, Soc. Neurosci. Abstr.

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Authors: Makino, S., Gold, P. W., & Schulkin, J.
Affiliations: National Institute of Mental Health (US)
Corresponding author: Schulkin, Jay
ORCID: Schulkin, Jay
Venue: Brain Research
Publisher: Elsevier BV
Published: 1994-03
Volume: 640
Issue: 1-2
Pages: 105-112
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(94)91862-7
OpenAlex: W2076200184
Cited by: 400
References: 40
Citations by year: 2026: 8 · 2025: 1 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 13 · 2019: 4 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 16
FWCI: 7.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
Funders: National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: corticosterone, corticotropin-releasing factor, CRH mRNA expression, central amygdala, paraventricular nucleus, glucocorticoids, hypothalamic-pituitary-adrenal axis, dose-dependent effects, fear and anxiety
MeSH terms: Adrenal Glands, Adrenocorticotropic Hormone, Amygdala, Animals, Autoradiography, Corticosterone, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Male, Organ Size, Paraventricular Hypothalamic Nucleus, RNA, Messenger, Thymus Gland, Rats, Sprague-Dawley, In Situ Hybridization, Rats

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Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus

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