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Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus
Open accessAbstract
Using in situ hybridization histochemistry, we report differential expression of corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA) and the parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following systemic treatment with corticosterone (CORT) in adrenally-intact rats. Both injection of low (1 mg/kg/day) and high (5 mg/day) CORT reduced CRH mRNA expression in the PVN in a dose-dependent manner, although it returned to normal at the low dose by 14 days. By contrast, the high dose of CORT increased CRH mRNA transiently in the CEA at 4 days, although the low dose of CORT decreased it at 14 days. In a second experiment, we implanted a slowly-releasing CORT pellet for 2 weeks (200 mg, 60 day release) subcutaneously. This treatment produced an elevation of CRH mRNA in the CEA both at 1 and 2 weeks, whereas CRH mRNA in the PVN was decreased to a large extent as seen in the high CORT group of the first experiment. These results suggest that glucocorticoids can facilitate CRH mRNA expression in the CEA, a site implicated in anxiety and fear, while restraining the hypothalamic-pituitary-adrenal axis as indicated by the reduction in CRH mRNA in the PVN.
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“previous studies have shown that chronic corticosterone administration upregulates the CRF mRNA level in CeAL and BNSTL neurons (Liu et al, 2004; Makino et al, 1994a, b; Shepard et al, 2000; Swanson and Simmons, 1989; Watts and Sanchez-Watts, 1995) and interacts synergistically with CRF to increase startle amplitude (Lee et al, 1994).”
From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Makino et al, 1994a, b
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Metadata
- Authors
- Makino, S., Gold, P. W., & Schulkin, J.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Schulkin, Jay
- ORCID
- Schulkin, Jay
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 640
- Issue
- 1-2
- Pages
- 105-112
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2076200184
- Cited by
- 400
- References
- 40
- Citations by year
- 2026: 8 · 2025: 1 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 13 · 2019: 4 · 2018: 14 · 2017: 11 · 2016: 14 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 16
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- corticosterone, corticotropin-releasing factor, CRH mRNA expression, central amygdala, paraventricular nucleus, glucocorticoids, hypothalamic-pituitary-adrenal axis, dose-dependent effects, fear and anxiety
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Amygdala, Animals, Autoradiography, Corticosterone, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Male, Organ Size, Paraventricular Hypothalamic Nucleus, RNA, Messenger, Thymus Gland, Rats, Sprague-Dawley, In Situ Hybridization, Rats
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