Social play alters regional brain opioid receptor binding in juvenile rats
Abstract
An in vivo autoradiographic procedure was employed to visualize local changes in brain opioid receptor occupancy in juvenile rats. This procedure is based on the assumption that released endogenous ligand will exclude exogenously applied tracer, in this case [3H]diprenorphine, from opioid receptors. Increases in availability of opioid peptides will then result in decreased opioid receptor binding. From behavioral studies there is ample evidence that opioid systems are involved in the regulation of social play behavior in juvenile rats. In the present study, changes in regional brain opioid activity as a result of social isolation-induced social play behavior were monitored. Twenty-one-day-old rats were socially isolated for 0, 3.5 or 24 h prior to testing, and tested alone or in a dyadic encounter. After behavioral testing, [3H]diprenorphine was administered and the brain was prepared for autoradiography. Social isolation caused increases in social behavior (dyadic encounters) but not in non-social behavior (singly tested animals). Modest differences in brain opioid receptor binding due to social isolation, social play behavior, or an interaction of the two, were found in claustrum, nucleus accumbens, globus pallidus, paraventricular and arcuate nuclei of the hypothalamus, and the dorsolateral and paratenial thalamic nuclei. These results support the notion that opioid systems are involved in the regulation of social play behavior. In addition, the observation of changes in o…
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The increase in play after social isolation depends on the duration of isolation.
“Though individual play motivation can be influenced by several factors, social isolation increases the motivation to initiate play in adolescent rats, and the increase in play depends on the duration of isolation (Niesink & van Ree, 1989;Vanderschuren, Stein et al., 1995).”
From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Vanderschuren, Stein et al., 1995
Social isolation increases the motivation to initiate play in adolescent rats.
“Though individual play motivation can be influenced by several factors, social isolation increases the motivation to initiate play in adolescent rats, and the increase in play depends on the duration of isolation (Niesink & van Ree, 1989;Vanderschuren, Stein et al., 1995).”
From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Vanderschuren, Stein et al., 1995
The Play-In-Pairs test can be a useful tool for a relatively quick assessment of playfulness.
“This result supports previous research suggesting that the Play-In-Pairs test can be a useful tool for a relatively quick assessment of playfulness (Niesink & van Ree, 1989;Pellis & McKenna, 1992;Vanderschuren, Stein et al., 1995).”
From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Vanderschuren, Stein et al., 1995
The 3 hr isolation period was chosen because it was shown to induce a substantial increase of social play in rats without reaching a ceiling effect.
“This isolation period was chosen because it was shown to induce a substantial increase of social play in rats, without reaching a ceiling effect (Niesink & van Ree, 1989;Vanderschuren, Niesink et al., 1995;Vanderschuren, Stein et al., 1995).”
From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Vanderschuren, Stein et al., 1995
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- Authors
- Vanderschuren, L. J. M. J., Stein, E. A., Wiegant, V. M., & Van Ree, J. M.
- Affiliations
- Utrecht University (NL)
- Medical College of Wisconsin (US)
- Corresponding author
- Vanderschuren, Louk J.M.J.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 680
- Issue
- 1-2
- Pages
- 148-156
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2031351527
- Cited by
- 88
- References
- 5
- Citations by year
- 2025: 2 · 2023: 5 · 2022: 2 · 2020: 5 · 2019: 11 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social play, opioid receptors, social isolation, young rats, endogenous opioids, reward, nucleus accumbens, hypothalamus, thalamus, claustrum, globus pallidus, paraventricular nucleus, arcuate nucleus
- MeSH terms
- Animals, Animals, Newborn, Autoradiography, Brain, Diprenorphine, Interpersonal Relations, Male, Play and Playthings, Receptors, Opioid, Social Behavior, Social Isolation, Rats, Wistar, Rats
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