Cited by 200Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The formation of peroxynitrite in vivo from nitric oxide and superoxide

Squadrito, Giuseppe L., Pryor, William A.·1995·Chemico-Biological Interactions

Abstract

Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for superoxide near the surface of endothelial cells, based on competition kinetics.

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Crossref · 10.1016/0009-2797(94)03591-u

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35 of 35 references verified0 citation errors · 0 not checkable

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  • Peroxynitrite can nitrate tyrosine or tryptophan residues or oxidise methionine residues.

    “In addition, peroxynitrite is capable of nitrating tyrosine or tryptophan residues, or oxidising methionine residues [123,124,125,126,127,128].”

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Authors
Squadrito, G. L., & Pryor, W. A.
Affiliations
Louisiana State University (US)
Corresponding author
Pryor, William A.
Venue
Chemico-Biological Interactions
Publisher
Elsevier BV
Published
1995-05
Volume
96
Issue
2
Pages
203-206
ISSN
0009-2797 (ISSN-L)
OpenAlex
W2076052581
Cited by
200
References
35
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 1 · 2014: 6 · 2013: 7 · 2012: 3
FWCI
2.24
Type
journal article
Language
en
Open access
closed
Locations
  • Chemico-Biological Interactions (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
peroxynitrite, nitric oxide, superoxide, nitrosative stress, endothelial cells, competition kinetics, reactive oxygen species, in vivo formation
MeSH terms
Endothelium, Vascular, Kinetics, Nitrates, Nitric Oxide, Superoxides

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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