The formation of peroxynitrite in vivo from nitric oxide and superoxide
Abstract
Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for superoxide near the surface of endothelial cells, based on competition kinetics.
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Peroxynitrite can nitrate tyrosine or tryptophan residues or oxidise methionine residues.
“In addition, peroxynitrite is capable of nitrating tyrosine or tryptophan residues, or oxidising methionine residues [123,124,125,126,127,128].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [123]
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- Authors
- Squadrito, G. L., & Pryor, W. A.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Pryor, William A.
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 96
- Issue
- 2
- Pages
- 203-206
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2076052581
- Cited by
- 200
- References
- 35
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 1 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- peroxynitrite, nitric oxide, superoxide, nitrosative stress, endothelial cells, competition kinetics, reactive oxygen species, in vivo formation
- MeSH terms
- Endothelium, Vascular, Kinetics, Nitrates, Nitric Oxide, Superoxides
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