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The formation of peroxynitrite in vivo from nitric oxide and superoxide
Abstract
Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for superoxide near the surface of endothelial cells, based on competition kinetics.
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“In addition, peroxynitrite is capable of nitrating tyrosine or tryptophan residues, or oxidising methionine residues [123,124,125,126,127,128].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [123]
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Metadata
- Authors
- Squadrito, G. L., & Pryor, W. A.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Pryor, William A.
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 96
- Issue
- 2
- Pages
- 203-206
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2076052581
- Cited by
- 200
- References
- 35
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 1 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- peroxynitrite, nitric oxide, superoxide, nitrosative stress, endothelial cells, competition kinetics, reactive oxygen species, in vivo formation
- MeSH terms
- Endothelium, Vascular, Kinetics, Nitrates, Nitric Oxide, Superoxides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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