Post-coital contraceptive activity of crude extracts of Sri Lankan marine red algae
Abstract
This study investigates the potential of marine red algae as a source for post-coital contraceptive agents using three varieties: Gracilaria corticata, Gelidiella acerosa and Jania sp. Methanol: methylene chloride (1:1) extracts of these red algae were made and were orally administered (500 or 1000 mg/kg/day) to female rats from day 1 to day 7 of pregnancy. The higher dose of Gracilaria corticata and both doses of Gelidiella acerosa extracts produced significant post-coital contraceptive activities without any marked side effects. Furthermore, the post-coital contraceptive activity of the latter extract was dose-dependent. On the other hand, extract made from Jania sp. had no significant post-coital contraceptive action. The post-coital contraceptive activity of Gracilaria corticata was due to enhanced pre-implantation loss and of Gelidiella acerosa was due to elevated post-implantation loss. These findings indicate that marine red algae is a useful source to be harvested for potential post-coital contraceptive drugs.
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Extracts from red algae administered to female rats in the first seven days of pregnancy have post-coital contraceptive protection without relevant adverse effects.
“Different studies [49,50] with extracts from red algae were carried out. These extracts were administrated to female rats in the first seven days of their pregnancies. As result, it was demonstrated that these extracts have post-coital contraceptive protection in the rats without showing any relevant adverse effect.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [49]
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- Authors
- Ratnasooriya, W.
- Affiliations
- University of Colombo (LK)
- Corresponding author
- Ratnasooriya, W
- Venue
- Contraception
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 50
- Issue
- 3
- Pages
- 291-299
- ISSN
- 0010-7824 (ISSN-L)
- OpenAlex
- W2068806885
- Cited by
- 25
- References
- 17
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 3
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Contraception (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- emergency contraception, marine red algae, Gracilaria corticata, Gelidiella acerosa, Jania, plant extracts, preimplantation loss, postimplantation loss, dose-dependent effects, female rats
- MeSH terms
- Rhodophyta, Animals, Contraceptives, Postcoital, Female, Pregnancy, Sri Lanka, Rats
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