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Cited by 249Biochemical Acid Research StudiesMitochondrial Function and PathologyMicrobial metabolism and enzyme function

The role of citric acid in intermediate metabolism in animal tissues

Krebs, H.A., Johnson, W.A.·1980·FEBS Letters
DOI 10.1016/0014-5793(80)80564-3
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Abstract

In the present paper experiments are reported which throw new light on the problem of the intermediate stages of oxidation of carbohydrate; in conjunction with the work of Szent‐Györgyi 20), Stare and Baumann 19) and Martius and Knoop 13,14) the new experiments allow us to outline the principal steps of the oxidation of sugar in animal tissues.

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Crossref · 10.1016/0014-5793(80)80564-3

Cites

22 of 22 references verified0 citation errors · 0 not checkable

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  • The TCA cycle is a broadly conserved metabolic pathway that harnesses high-energy electrons from fuel sources.

    “At the nexus of both catabolic and anabolic metabolism lies the tricarboxylic acid (TCA) cycle, a broadly conserved metabolic pathway consisting of a cyclic series of chemical reactions that harness high-energy electrons from fuel sources (1, 2, 3).”

    From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]

  • By adding malonate, an inhibitor of succinate oxidation, Krebs and Johnson found that succinate accumulated when OAA was added to muscle, implying the series of reactions was cyclical.

    “By adding malonate, an inhibitor of succinate oxidation, they found that succinate accumulated when OAA was added to muscle, implying that this series of reactions was cyclical in nature (2, 32).”

    From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]

  • Krebs and Johnson found that citrate did not disappear during this process, indicating it was being continuously reformed.

    “Moreover, they found that citrate did not disappear during this process, indicating that it was being continuously reformed (2, 32).”

    From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]

  • Krebs and Johnson discovered that citrate was readily oxidized by minced pigeon breast muscle and that citrate addition increased oxygen uptake beyond the amount necessary for complete oxidation of added citrate.

    “These crucial experiments teed up the findings of Hans Krebs and his colleague William Johnson (2) in Enzymologia in 1937, in which they discovered that citrate was readily oxidized by minced pigeon breast muscle and that citrate addition increased oxygen uptake beyond the amount necessary for the complete oxidation of the added citrate, indicating that citrate itself was stimulating consumption”

    From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]

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Authors
Krebs, H. A., & Johnson, W. A.
Affiliations
University of Sheffield (GB)
Venue
FEBS Letters
Publisher
Wiley
Published
1980-08-25
Volume
117
Issue
S1
Pages
K1-10
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/0014-5793(80)80564-3
OpenAlex
W2019649025
Cited by
249
References
22
Citations by year
2026: 9 · 2025: 14 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 18 · 2020: 16 · 2019: 9 · 2018: 17 · 2017: 14 · 2016: 9 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 6
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7751 d)
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords
citric acid, intermediary metabolism, carbohydrate oxidation, sugar oxidation, animal tissues, TCA cycle
MeSH terms
Biochemistry, Citric Acid Cycle, England, History, 20th Century

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