Cited by 185Microbial metabolism and enzyme functionMicrobial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology

The glyoxylate shunt, 60 years on

Dolan, Stephen K., Welch, Martin·2018·Annual Review of Microbiology

Abstract

2017 marks the 60th anniversary of Krebs’ seminal paper on the glyoxylate shunt (and coincidentally, also the 80th anniversary of his discovery of the citric acid cycle). Sixty years on, we have witnessed substantial developments in our understanding of how flux is partitioned between the glyoxylate shunt and the oxidative decarboxylation steps of the citric acid cycle. The last decade has shown us that the beautifully elegant textbook mechanism that regulates carbon flux through the shunt in E. coli is an oversimplification of the situation in many other bacteria. The aim of this review is to assess how this new knowledge is impacting our understanding of flux control at the TCA cycle/glyoxylate shunt branch point in a wider range of genera, and to summarize recent findings implicating a role for the glyoxylate shunt in cellular functions other than metabolism.

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Crossref · 10.1146/annurev-micro-090817-062257

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85 of 85 references verified0 citation errors · 0 not checkable

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  • The glyoxylate shunt is an anaplerotic reaction of the TCA cycle developed in numerous species, which bypasses two NADH-generating steps.

    “For instance, the glyoxylate shunt GS is an anaplerotic reaction of the tricarboxylic acid TCA cycle developed in numerous species, which bypasses two NADH-generating steps [194].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [194]

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Authors
Dolan, S. K., & Welch, M.
Affiliations
University of Cambridge (GB)
Venue
Annual Review of Microbiology
Published
2018-09-08
Volume
72
Issue
1
Pages
309-330
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
OpenAlex
W2892337114
Cited by
180
References
85
Citations by year
2026: 33 · 2025: 24 · 2024: 19 · 2023: 22 · 2022: 20 · 2021: 25 · 2020: 27 · 2019: 9 · 2018: 1
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Biotechnology and Biological Sciences Research Council (BB/R005435/1, BB/M019411/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
glyoxylate cycle, TCA cycle, carbon flux partitioning, oxidative decarboxylation, flux control, Escherichia coli, bacterial metabolism
MeSH terms
Carbon, Escherichia coli, Glyoxylates, Metabolic Networks and Pathways, Metabolic Flux Analysis

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