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Cited by 82Mesenchymal stem cell researchImmune cells in cancerCancer Cells and Metastasis

The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

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Luque-Campos, Noymar, Bustamante-Barrientos, Felipe A., Pradenas, Carolina, García, Cynthia, Araya, María Jesús, Bohaud, Candice, Contreras-López, Rafael, Elizondo-Vega, Roberto +3 more·2021·Frontiers in Immunology
DOI 10.3389/fimmu.2021.624746PMC PMC8213396
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Abstract

Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

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  • Mesenchymal stem cells, by secretion of IDO, IL-6, and PGE2, participate in the differentiation of macrophages to the immunosuppressive M2 phenotype.

    “MSCs by secretion of IDO, IL-6, and PGE2 participate in the differentiation of macrophages to immunosuppressive M2 (tissue repair-associated) phenotype [80–82].”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [80]

    The section on MSC–macrophage interaction says MSC-secreted IDO promotes anti-inflammatory M2 polarization, and Figure 2 lists PGE2 and IDO among factors through which MSCs induce M2-like macrophages. The copy does not identify MSC-secreted IL-6 as a mediator of that differentiation, so the three-factor claim is only partly supported. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
Luque-Campos, N., Bustamante-Barrientos, F. A., Pradenas, C., García, C., Araya, M. J., Bohaud, C., Contreras-López, R., Elizondo-Vega, R., Djouad, F., Luz-Crawford, P., & Vega-Letter, A. M.
Affiliations
  • Universidad de Los Andes, Chile (CL)
  • Universidad Mayor (CL)
  • Inserm (FR)
  • University of Concepción (CL)
Corresponding author
Vega-Letter, Ana María
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2021-06-04
Volume
12
Pages
624746-624746
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2021.624746
PMC
PMC8213396
OpenAlex
W3166294177
Cited by
82
References
201
Citations by year
2026: 25 · 2025: 16 · 2024: 18 · 2023: 15 · 2022: 5 · 2021: 3
FWCI
1.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
Funders
Fondo Nacional de Desarrollo Científico y Tecnológico
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
mesenchymal stem cells, macrophages, metabolic reprogramming, macrophage plasticity, immunomodulation, macrophage polarization, tissue repair, inflammation, cancer
MeSH terms
Cell Plasticity, Animals, Cell Communication, Energy Metabolism, Humans, Macrophages, Phenotype, Signal Transduction, Inflammation Mediators, Mesenchymal Stem Cells, Cellular Microenvironment, Cellular Reprogramming

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