The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
‘Quanta’ Ca2+ release and the control of Ca2+ entry by inositol phosphates ‐ a possible mechanism
Open accessAbstract
The release of Ca 2+ from intracellular stores by sub‐optimal doses of inositol trisphosphate has been shown to be dose‐related (‘quantal’), and a simple model is proposed here to account for this phenomenon. It is suggested that there is a regulatory Ca 2+‐binding site on, or associated with, the luminal domain of the InsP 3 receptor, which allosterically controls Ca 2+ efflux, and the affinity for Ca 2+ of that site is modulated by InsP 3 binding to the cytoplasmic domain of the receptor; a similar mechanism applied to the ryanodine receptor might also explain some aspects of Ca 2+ ‐induced Ca 2+ release. The stimulated entry of Ca 2+ into a cell which occurs upon activation of inositide‐linked receptors has been variously and confusingly proposed to be regulated by InsP 3, InsP 4, and/or a ‘capacitative’ Ca 2+ pool; the mechanism of InsP, receptor action suggested here is shown to lead to a potential reconciliation of all these conflicting proposals.
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Cites
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Takeshima, H., Nishimura, S., Matsumoto, T., Ishida, H., Kangawa, K., Minamino, N., Matsuo, H., Ueda, M., Hanaoka, M., Hirose, T., et al. (1989) · Nature · doi:10.1038/339439a0 · Cited by 1,146
Hormone-evoked calcium release from intracellular stores is a quantal process
Muallem, S., Pandol, S. J., & Beeker, T. G. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31244-9 · Cited by 307
Cited by
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Depletion of intracellular calcium stores activates a calcium current in mast cells
Hoth, M., & Penner, R. (1992) · Nature · doi:10.1038/355353a0 · Cited by 1,751
Capacitative calcium entry revisited
Putney, J. W. (1990) · Cell Calcium · doi:10.1016/0143-4160(90)90016-n · Cited by 1,487
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Metadata
- Authors
- Irvine, R. F.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1990-04-09
- Volume
- 263
- Issue
- 1
- Pages
- 5-9
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2086669662
- Cited by
- 739
- References
- 2
- FWCI
- 48.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: ‘Quanta’ Ca2+ release and the control of Ca2+ entry by inositol phosphates ‐ a possible mechanism. https://app.cochat.ai/papers/10.1016/0014-5793(90)80692-c
- The paper
- Irvine, R. F. (1990). ‘Quanta’ Ca2+ release and the control of Ca2+ entry by inositol phosphates ‐ a possible mechanism. FEBS Letters. https://doi.org/10.1016/0014-5793(90)80692-c
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
