The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Biologically relevant metal ion‐dependent hydroxyl radical generation An update
Open accessAbstract
Transition metal ions, especially iron, appear to be important mediators of oxidative damage in vivo. Iron(II) reacts with H 2 O 2 to give more‐reactive radicals. On the basis of ESR spin‐trapping data with DMPO, supported by aromatic hydroxylation studies and patterns of DNA base modification, it is concluded that hydroxyl radical (OH•) is likely to be the major damaging species formed in Fenton Systems under biologically‐relevant conditions (which include iron concentrations no higher than the micromolar range). Although reactive oxo‐iron species (such as ferryl and perferryl) may also be important, chemical evidence for their formation and identity in biologically relevant Fenton systems is currently lacking. Studies at alkaline pH values show that iron(IV) and iron(V) species are highly oxidizing under those reaction conditions, with a pattern of reactivity different from that of OH•.
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Cites
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Self-citationDNA damage and oxygen radical toxicity
Imlay, J. A., & Linn, S. (1988) · Science · doi:10.1126/science.3287616 · Cited by 1,974
Metal-catalyzed oxidation of proteins. Physiological consequences
Stadtman, E. R., & Oliver, C. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52199-2 · Cited by 862
Nitric oxide as an antioxidant
Kanner, J., Harel, S., & Rina, G. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90452-o · Cited by 429
Bissett, D. L., Chatterjee, R., & Hannon, D. P. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02009.x · Cited by 128
Cited by
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Self-citationKohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178
Antioxidants in health and disease
Young, I. S., & Woodside, J. V. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.3.176 · Cited by 1,949
Toxicity of iron and hydrogen peroxide: the Fenton reaction
Winterbourn, C. C. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03532-x · Cited by 1,415
The ZIP family of metal transporters
Guerinot, M. L. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00138-3 · Cited by 1,200
Metadata
- Authors
- Halliwell, B., & Gutteridge, J. M. C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1992-07-27
- Volume
- 307
- Issue
- 1
- Pages
- 108-112
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1990465549
- Cited by
- 883
- References
- 5
- FWCI
- 19.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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