CHRONIC ULTRAVIOLET RADIATION‐INDUCED INCREASE IN SKIN IRON and THE PHOTOPROTECTIVE EFFECT OF TOPICALLY APPLIED IRON CHELATORS 1,*

Bissett, Donald L.; Chatterjee, Ranjit; Hannon, Daniel P.

doi:10.1111/j.1751-1097.1991.tb02009.x

Cited by 128Skin Protection and AgingEffects of Radiation Exposuremelanin and skin pigmentation

CHRONIC ULTRAVIOLET RADIATION‐INDUCED INCREASE IN SKIN IRON and THE PHOTOPROTECTIVE EFFECT OF TOPICALLY APPLIED IRON CHELATORS 1,*

Bissett, Donald L., Chatterjee, Ranjit, Hannon, Daniel P.·1991·Photochemistry and Photobiology

DOI 10.1111/j.1751-1097.1991.tb02009.x

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Abstract

In the skin of albino hairless mice (Skh:HR-1) there is a basal level of non-heme iron. Chronic exposure of mice to sub-erythemal doses of ultraviolet (UV) B radiation results in an increased skin level of non-heme iron. The iron increase may be the result of a UVB radiation-induced increase in vascular permeability, which we measured in vivo with the dye marker Evans Blue. We also observed greater non-heme iron in sun-exposed vs non-exposed body sites of human skin, suggesting that similar events occur in man. Iron may have a role in skin photodamage by participating in formation of reactive oxygen species. These species have been implicated in skin photodamage. It is known that iron can contribute to oxygen radical production by acting catalytically in the formation of species such as hydroxyl radical. While the basal level of skin iron may be available for catalysis, the elevated iron content of UV-exposed skin increases the potential for iron-catalyzed radical production. Topical application of certain iron chelators to Skh albino hairless mice dramatically delayed the onset of UVB radiation-induced skin photodamage. Non-chelating analogs provided no significant protection.

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Authors: Bissett, D. L., Chatterjee, R., & Hannon, D. P.
Affiliations: Procter & Gamble (United States) (US)
Corresponding author: Bissett, Donald L.
Venue: Photochemistry and Photobiology
Publisher: Wiley
Published: 1991-08
Volume: 54
Issue: 2
Pages: 215-223
ISSN: 0031-8655 (ISSN-L)
1751-1097
DOI: 10.1111/j.1751-1097.1991.tb02009.x
OpenAlex: W2073244205
Cited by: 128
References: 56
Citations by year: 2026: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2013: 2 · 2012: 3
FWCI: 6.61
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5998 d)
Locations: Photochemistry and Photobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: non-heme iron, UV-B radiation, photodamaged skin, iron chelators, reactive oxygen species, hydroxyl radicals, vascular permeability, Evans blue, sun-exposed skin
MeSH terms: Animals, Chelating Agents, Female, Iron, Mice, Hairless, Phenanthrolines, Radiation-Sensitizing Agents, Skin, Ultraviolet Rays, 2,2'-Dipyridyl, Mice

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CHRONIC ULTRAVIOLET RADIATION‐INDUCED INCREASE IN SKIN IRON and THE PHOTOPROTECTIVE EFFECT OF TOPICALLY APPLIED IRON CHELATORS 1,*

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