The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Wortmannin inhibits insulin‐stimulated but not contraction‐stimulated glucose transport activity in skeletal muscle
Open accessAbstract
In skeletal muscle, glucose transport is stimulated by insulin, contractions and hypoxia. In this study, we used the phosphatidylinositol 3‐kinase (PI 3‐kinase) inhibitor wortmannin to examine whether (i) PI 3‐kinase activity is necessary for stimulation of glucose transport by insulin in muscle, and (ii) PI 3‐kinase mediates a step in the pathway by which contractions/hypoxia stimulate glucose transport. Wortmannin completely blocked insulin‐ and insulin‐like growth factor‐1‐stimulated glucose transport in muscle. In contrast, wortmannin had no effect on the stimulation of glucose transport by contractions or hypoxia, providing evidence that PI 3‐kinase activity is not involved in the activation of glucose transport by these stimuli.
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Cites
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Stimulation of glucose transport in skeletal muscle by hypoxia
Cartee, G. D., Douen, A. G., Ramlal, T., Klip, A., & Holloszy, J. O. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.4.1593 · Cited by 305
Self-citationMuscle glucose transport: interactions of in vitro contractions, insulin, and exercise
Constable, S. H., Favier, R. J., Cartee, G. D., Young, D. A., & Holloszy, J. O. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.6.2329 · Cited by 99
Self-citationContraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat
Brozinick, J. T., Etgen, G. J., Yaspelkis, B. B., & Ivy, J. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.1.382 · Cited by 89
Cited by
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084
Exercise, GLUT4, and skeletal muscle glucose uptake
Richter, E. A., & Hargreaves, M. (2013) · Physiological Reviews · doi:10.1152/physrev.00038.2012 · Cited by 1,407
Exercise, Glucose Transport, and Insulin Sensitivity
Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.235 · Cited by 1,056
Exercise-stimulated glucose uptake — regulation and implications for glycaemic control
Sylow, L., Kleinert, M., Richter, E. A., & Jensen, T. E. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.162 · Cited by 498
Exercise-induced increase in muscle insulin sensitivity
Holloszy, J. O. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00123.2005 · Cited by 494
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Metadata
- Authors
- Lee, A. D., Hansen, P. A., & Holloszy, J. O.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-03-13
- Volume
- 361
- Issue
- 1
- Pages
- 51-54
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2155653958
- Cited by
- 235
- References
- 4
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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