Cited by 89Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism

Contraction-activated glucose uptake is normal in insulin-resistant muscle of the obese Zucker rat

Brozinick, J. T., Etgen, G. J., Yaspelkis, B. B., Ivy, J. L.·1992·Journal of Applied Physiology

Abstract

The rates of muscle glucose uptake of lean and obese Zucker rats were assessed via hindlimb perfusion under basal conditions (no insulin), in the presence of a maximal insulin concentration (10 mU/ml), and after electrically stimulated muscle contraction in the absence of insulin. The perfusate contained 28 mM glucose and 7.5 microCi/mmol of 2-deoxy-D-[3H-(G)]glucose. Glucose uptake rates in the soleus (slow-twitch oxidative fibers), red gastrocnemius (fast-twitch oxidative-glycolytic fibers), and white gastrocnemius (fast-twitch glycolytic fibers) under basal conditions and after electrically stimulated muscle contraction were not significantly different between the lean and obese rats. However, the rate of glucose uptake during insulin stimulation was significantly lower for obese than for lean rats in all three fiber types. Significant correlations were found for insulin-stimulated glucose uptake and glucose transporter protein isoform (GLUT-4) content of soleus, red gastrocnemius, and white gastrocnemius of lean (r = 0.79) and obese (r = 0.65) rats. In contrast, the relationships between contraction-stimulated glucose uptake and muscle GLUT-4 content of lean and obese rats were negligible because of inordinately low contraction-stimulated glucose uptakes by the solei. These results suggest that maximal skeletal muscle glucose uptake of obese Zucker rats is resistant to stimulation by insulin but not to contractile activity. In addition, the relationship between contraction-stimulated glucose uptake and GLUT-4 content appears to be fiber-type specific.

Integrity signals

Registry

Crossref · 10.1152/jappl.1992.73.1.382

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Contraction-mediated glucose uptake is maintained in humans and diet and genetic rodent models of insulin resistance.

    “4) Contraction-mediated glucose uptake is maintained in humans and diet and genetic rodent models of insulin resistance [111-114].”

    From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [114]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Brozinick, J. T., Etgen, G. J., Yaspelkis, B. B., & Ivy, J. L.
Affiliations
The University of Texas at Austin (US)
Venue
Journal of Applied Physiology
Published
1992-07-01
Volume
73
Issue
1
Pages
382-387
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W2315090378
Cited by
89
References
27
Citations by year
2021: 2 · 2018: 1 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 2
FWCI
1.83
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
skeletal muscle glucose uptake, insulin resistance, muscle contraction, GLUT4, skeletal muscle fiber types, soleus muscle, gastrocnemius, obesity, Zucker rats, hindlimb perfusion, 2-deoxyglucose
MeSH terms
Animals, Deoxyglucose, Electric Stimulation, Female, Glucose, Insulin Resistance, Isomerism, Monosaccharide Transport Proteins, Muscle Contraction, Muscles, Obesity, Rats, Zucker, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review