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Cited by 609

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Peroxynitrite‐mediated oxidative protein modifications

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Ischiropoulos, Harry, Al-Mehdi, Abu B.·1995·FEBS Letters
DOI 10.1016/0014-5793(95)00307-u
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Abstract

Proteins are targets of reactive species and detection of oxidatively modified proteins is often used as an index of oxidative stress. Peroxynitrite is a strong oxidant formed by reaction of nitric oxide with superoxide. Using fatty acid‐free bovine serum albumin as a model we examined peroxynitrite‐mediated protein modifications. The reaction of protein with peroxynitrite resulted in the oxidation of tryptophan and cysteine, in the nitration of tyrosine, in the formation of dityrosine, in the production of 2,4 dinitrophenylhydrazine‐reactive carbonyls and in protein fragmentation. The formation of 3‐nitrotyrosine represents a specific peroxynitrite‐mediated protein modification that is different from modifications mediated by reactive oxygen species.

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Metadata

Authors
Ischiropoulos, H., & Al-Mehdi, A. B.
Venue
FEBS Letters
Publisher
Wiley
Published
1995-05-15
Volume
364
Issue
3
Pages
279-282
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/0014-5793(95)00307-u
OpenAlex
W1999589434
Cited by
609
References
0
FWCI
9.36
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Peroxynitrite‐mediated oxidative protein modifications. https://app.cochat.ai/papers/10.1016/0014-5793(95)00307-u
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Ischiropoulos, H., & Al-Mehdi, A. B. (1995). Peroxynitrite‐mediated oxidative protein modifications. FEBS Letters. https://doi.org/10.1016/0014-5793(95)00307-u

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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