The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13)
Open accessAbstract
Degradation of the large cartilage proteoglycan aggrecan in arthritis involves an unidentified enzyme aggrecanase, and at least one of the matrix metalloproteinases. Proteinase‐sensitive cleavage sites in the aggrecan interglobular domain (IGD) have been identified for many of the human MMPs, as well as for aggrecanase and other proteinases. The major MMP expressed by chondrocytes stimulated with retinoic acid to degrade their matrix is collagenase‐3 or MMP‐13. Because of its potential role in aggrecan degradation we examined the specificity of MMP‐13 for an aggrecan substrate. The results show that MMP‐13 cleaves aggrecan in the IGD at the same site (..PEN 341‐FFG..) identified for other members of the MMP family, and also at a novel site ..VKP 384‐VFE.. not previously observed for other proteinases.
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Cites
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Self-citationSandy, J. D., Flannery, C. R., Neame, P. J., & Lohmander, L. S. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115742 · Cited by 411
Self-citationLohmander, L. S., Hoerrner, L. A., & Lark, M. W. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360207 · Cited by 339
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
Fosang, A. J., Neame, P. J., Last, K., Hardingham, T. E., Murphy, G., & Hamilton, J. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41799-1 · Cited by 297
Self-citationSandy, J. D., Neame, P. J., Boynton, R. E., & Flannery, C. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31499-6 · Cited by 284
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Cited by
Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering
Zhu, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.044 · Cited by 1,457
Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins
Tortorella, M. D., Burn, T. C., Pratta, M. A., Abbaszade, I., Hollis, J. M., Liu, R., Rosenfeld, S. A., Copeland, R. A., Decicco, C. P., Wynn, R., et al. (1999) · Science · doi:10.1126/science.284.5420.1664 · Cited by 686
Proteases involved in cartilage matrix degradation in osteoarthritis
Troeberg, L., & Nagase, H. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.06.020 · Cited by 579
Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family
Abbaszade, I., Liu, R.-Q., Yang, F., Rosenfeld, S. A., Ross, O. H., Link, J. R., Ellis, D. M., Tortorella, M. D., Pratta, M. A., Hollis, J. M., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23443 · Cited by 490
Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis
Withrow, J., Murphy, C., Liu, Y., Hunter, M., Fulzele, S., & Hamrick, M. W. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1178-8 · Cited by 267
Metadata
- Authors
- Fosang, A. J., Last, K., Knäuper, V., Murphy, G., & Neame, P. J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-02-12
- Volume
- 380
- Issue
- 1-2
- Pages
- 17-20
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2070952973
- Cited by
- 375
- References
- 31
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fosang, A. J., Last, K., Knäuper, V., Murphy, G., & Neame, P. J. (1996). Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13). FEBS Letters. https://doi.org/10.1016/0014-5793(95)01539-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
