The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis
Open accessAbstract
Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity in the US population. Extracellular vesicles (EVs), including exosomes and microvesicles, are now recognized to play important roles in cell-to-cell communication by transporting various proteins, microRNAs (miRNAs), and mRNAs. EV-derived proteins and miRNAs impact cell viability and cell differentiation, and are likely to play a prominent role in the pathophysiology of both OA and RA. Some of the processes by which these membrane-bound vesicles can alter joint tissue include extracellular matrix degradation, cell-to-cell communication, modulation of inflammation, angiogenesis, and antigen presentation. For example, EVs from IL-1β-stimulated fibroblast-like synoviocytes have been shown to induce osteoarthritic changes in chondrocytes. RA models have shown that EVs stimulated with inflammatory cytokines are capable of inducing apoptosis resistance in T cells, presenting antigen to T cells, and causing extracellular damage with matrix-degrading enzymes. EVs derived from rheumatoid models have also been shown to induce secretion of COX-2 and stimulate angiogenesis. Additionally, there is evidence that synovium-derived EVs may be promising biomarkers of disease in both OA and RA. The characterization of EVs in the joint space has also opened up the possibility for delivery of small molecules. This article reviews current knowledge on the role of EVs in both RA and OA, and their potential role as therapeutic targets for modulation of these debilitating diseases.
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Cites
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Cited by
Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
Mianehsaz, E., Mirzaei, H. R., Mahjoubin-Tehran, M., Rezaee, A., Sahebnasagh, R., Pourhanifeh, M. H., Mirzaei, H., & Hamblin, M. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1445-0 · Cited by 274
Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease
(2019) · doi:10.3390/cells8020154 · Cited by 169
Emerging Role of Extracellular Vesicles in Bone Remodeling
Liu, M., Sun, Y., & Zhang, Q. (2018) · Journal of Dental Research · doi:10.1177/0022034518764411 · Cited by 142
Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics
Sil, S., Dagur, R. S., Liao, K., Peeples, E. S., Hu, G., Periyasamy, P., & Buch, S. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09873-y · Cited by 109
Exosomes: Mediators of bone diseases, protection, and therapeutics potential
Behera, J., & Tyagi, N. (2018) · Oncoscience · doi:10.18632/oncoscience.421 · Cited by 101
Metadata
- Authors
- Withrow, J., Murphy, C., Liu, Y., Hunter, M., Fulzele, S., & Hamrick, M. W.
- Venue
- Arthritis Research & Therapy
- Published
- 2016-12
- Volume
- 18
- Issue
- 1
- Pages
- 286-286
- ISSN
- 1478-6354 (ISSN-L)
- 1478-6362
- OpenAlex
- W2558513068
- Cited by
- 267
- References
- 95
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Withrow, J., Murphy, C., Liu, Y., Hunter, M., Fulzele, S., & Hamrick, M. W. (2016). Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis. Arthritis Research & Therapy. https://doi.org/10.1186/s13075-016-1178-8
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