Plasticity in the enteric nervous system

Giaroni, Cristina; De Ponti, Fabrizio; Cosentino, Marco; Lecchini, Sergio; Frigo, Gianmario

doi:10.1016/s0016-5085(99)70295-7

Cited by 119Gastrointestinal motility and disordersNeuroscience and Neuropharmacology ResearchCongenital gastrointestinal and neural anomalies

Plasticity in the enteric nervous system

Giaroni, Cristina, De Ponti, Fabrizio, Cosentino, Marco, Lecchini, Sergio, Frigo, Gianmario·1999·Gastroenterology

DOI 10.1016/s0016-5085(99)70295-7

Open this paper in CoChat — free account

Abstract

Enteric ganglia can maintain integrated functions, such as the peristaltic reflex, in the absence of input from the central nervous system, which has a modulatory role. Several clinical and experimental observations suggest that homeostatic control of gut function in a changing environment may be achieved through adaptive changes occurring in the enteric ganglia. A distinctive feature of enteric ganglia, which may be crucial during the development of adaptive responses, is the vicinity of the final effector cells, which are an important source of mediators regulating cell growth. The aim of this review is to focus on the possible mechanisms underlying neuronal plasticity in the enteric nervous system and to consider approaches to the study of plasticity in this model. These include investigations of neuronal connectivity during development, adaptive mechanisms that maintain function after suppression of a specific neural input, and the possible occurrence of activity-dependent modifications of synaptic efficacy, which are thought to be important in storage of information in the brain. One of the applied aspects of the study of plasticity in the enteric nervous system is that knowledge of the underlying mechanisms may eventually enable us to develop strategies to correct neuronal alterations described in several diseases.

Integrity signals

Registry

Crossref · 10.1016/s0016-5085(99)70295-7

Cites

223 of 223 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

GAP-43 is expressed in both the CNS and the ENS; it is found in high levels throughout the lifespan in the hippocampus, as well as in the myenteric and submucous ganglia.
“An important neurodevelopment and plasticity-related protein growth-associated protein-43 (GAP-43) is expressed in both the CNS and the ENS; it is found in high levels throughout the lifespan in the hippocampus (Simmons et al., 2008), as well as in the myenteric and submucous ganglia (Giaroni et al., 1999;Stewart et al., 1992).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Giaroni et al., 1999

Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Physiology of the Gastrointestinal Tract
Johnson, L. R. (2006) · Elsevier eBooks · doi:10.1016/b978-0-12-088394-3.x5000-4 · Cited by 4,611 · see citing works
The Behavior of Organisms: An Experimental Analysis
Jones, F. N., & Skinner, B. F. (1939) · The American Journal of Psychology · doi:10.2307/1416495 · Cited by 4,388 · see citing works
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875 · see citing works
Experimental models of inflammatory bowel disease
Elson, C. O., Sartor, R. B., Tennyson, G. S., & Riddell, R. H. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90599-5 · Cited by 1,212 · see citing works
GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Jing, S., Wen, D., Yu, Y., Holst, P. L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81311-2 · Cited by 1,169 · see citing works
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B. L., Pozzan, T., & Volterra, A. (1998) · Nature · doi:10.1038/34651 · Cited by 1,143 · see citing works
A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract
Sanders, K. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690216 · Cited by 966 · see citing works
Modulation of neurotransmitter release by presynaptic autoreceptors
Starke, K., Göthert, M., & Kilbinger, H. J. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.3.864 · Cited by 927 · see citing works
De novo reconstitution of a functional mammalian urinary bladder by tissue engineering
Oberpenning, F., Meng, J., Yoo, J., & Atala, A. (1999) · Nature Biotechnology · doi:10.1038/6146 · Cited by 800 · see citing works
Microdomains for neuron–glia interaction: parallel fiber signaling to Bergmann glial cells
Grosche, J., Matyash, V., Möller, T., Verkhratsky, A., Reichenbach, A., & Kettenmann, H. (1999) · Nature Neuroscience · doi:10.1038/5692 · Cited by 700 · see citing works
Nerve growth factor: from neurotrophin to neurokine
Levi‐Montalcini, R., Skaper, S. D., Toso, R. D., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 684 · see citing works
Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice
Bush, T. G., Savidge, T., Freeman, T. C., Cox, H. J., Campbell, E. A., Mucke, L., Johnson, M. H., & Sofroniew, M. V. (1998) · Cell · doi:10.1016/s0092-8674(00)81571-8 · Cited by 590 · see citing works
GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney
Cacalano, G., Fariñas, I., Wang, L.-C., Hagler, K. E., Forgie, A. J., Moore, M. W., Armanini, M. P., PHILLIPS, H. S., Ryan, A. M., Reichardt, L. F., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80514-0 · Cited by 558 · see citing works
Neurologic Sequelae of Domoic Acid Intoxication Due to the Ingestion of Contaminated Mussels
Teitelbaum, J. S., Zatorre, R. J., Carpenter, S., Gendron, D., Evans, A. C., GJEDDE, A. H., & Cashman, N. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006213222505 · Cited by 555 · see citing works
Neurotrophins and depression
Altar, C. A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01309-7 · Cited by 535 · see citing works
The immunomodulation of enteric neuromuscular function: Implications for motility and inflammatory disorders
Collins, S. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70034-3 · Cited by 511 · see citing works
Abnormal colonic fermentation in irritable bowel syndrome
King, T. S., Elia, M., & Hunter, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02146-1 · Cited by 473 · see citing works
Intrinsic primary afferent neuronsof the intestine
Furness, J. B. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00051-8 · Cited by 412 · see citing works
Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity
Hölscher, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01065-5 · Cited by 408 · see citing works
THE ENTERIC NERVOUS SYSTEM AND REGULATION OF INTESTINAL MOTILITY
Kunze, W., & Furness, J. B. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.117 · Cited by 403 · see citing works
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
Shelton, D., Sutherland, J. S., Gripp, J. T., Camerato, T., Armanini, M. P., Phillips, H., Carroll, K., Spencer, S., & Levinson, A. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00477.1995 · Cited by 398 · see citing works
Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome
Munakata, J., Naliboff, B. D., Harraf, F., Kodner, A., Lembo, T., Chang, L., Silverman, D. H. S., & Mayer, E. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70219-1 · Cited by 380 · see citing works
Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation.
Singaram, C., Gaumnitz, E., Torbey, C., Ashraf, W., Quigley, E. M., Sengupta, A., & Pfeiffer, R. F. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92707-7 · Cited by 364 · see citing works
Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity- induced expression of Fos immunoreactivity
Kirchgessner, A., Tamir, H., & Gershon, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-01-00235.1992 · Cited by 362 · see citing works
Nitric Oxide Synthase Activity in Infantile Hypertrophic Pyloric Stenosis
Vanderwinden, J., Mailleux, P., Schiffmann, S. N., Vanderhaeghen, J., & Laet, M. D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208203270802 · Cited by 350 · see citing works
Volume transmission in the CNS and its relevance for neuropsychopharmacology
Zoli, M. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01343-7 · Cited by 346 · see citing works
Gene Targeting Reveals a Critical Role for Neurturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons
Heuckeroth, R. O., Enomoto, H., Grider, J. R., Golden, J. P., Hanke, J. A., Jackman, A., Molliver, D. C., Bardgett, M. E., Snider, W. D., Johnson, E. M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)81087-9 · Cited by 328 · see citing works
Development of the human gastrointestinal tract: Twenty years of progress
Montgomery, R. K., Mulberg, A. E., & Grand, R. J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70193-9 · Cited by 325 · see citing works
Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.
Sternini, C., Spann, M., Anton, B., Keith, D. E., Bunnett, N. W., von Zastrow, M., Evans, C. J., & Brecha, N. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9241 · Cited by 322 · see citing works
Short-bowel syndrome in children and adults
Vanderhoof, J., & Langnas, A. N. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352883 · Cited by 321 · see citing works
Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II
MacQueen, G., Marshall, J., Perdue, M., Siegel, S., & Bienenstock, J. (1989) · Science · doi:10.1126/science.2911721 · Cited by 318 · see citing works
Is rectal pain sensitivity a biological marker for irritable bowel syndrome: psychological influences on pain perception.
WHITEHEAD, W., & PALSSON, O. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70099-x · Cited by 314 · see citing works
Patients with achalasia lack nitric oxide synthase in the gastro‐oesophageal junction
Mearin, F., Mourelle, M., Guarner, F., Salas, A., Riveros‐Moreno, V., Moncada, S., & Malagelada, J. (1993) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1993.tb01292.x · Cited by 299 · see citing works
SENSITIZATION OF PAIN PATHWAYS IN THE SPINAL CORD: CELLULAR MECHANISMS
Baranauskas, G., & Nistri, A. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00067-1 · Cited by 295 · see citing works
The enteric nervous system
Dockray, G. J. (1988) · Neurochemistry International · doi:10.1016/0197-0186(88)90156-8 · Cited by 274 · see citing works
Mediators and pharmacology of visceral sensitivity: From basic to clinical investigations
Bueno, L. P., Fioramonti, J., Delvaux, M. M., & Frexinos, J. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70056-8 · Cited by 271 · see citing works
Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity
Canossa, M., Griesbeck, O., Berninger, B., Campana, G., Kolbeck, R., & Thoenen, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13279 · Cited by 268 · see citing works
Structural abnormalities of the nervous system in Crohn's disease and ulcerative colitis
Geboes, K., & Collins, S. (1998) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1998.00102.x · Cited by 255 · see citing works
Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma
Lennon, V. A., Sas, D. F., Busk, M. F., Scheithauer, B., Malagelada, J.-R., Camilleri, M., & Miller, L. J. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90593-a · Cited by 250 · see citing works
Astrocyte-like glia in the peripheral nervous system: an immunohistochemical study of enteric glia
Jessen, K., & Mirsky, R. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-11-02206.1983 · Cited by 246 · see citing works
From neural crest to bowel: Development of the enteric nervous system
Gershon, M. D., Chalazonitis, A., & Rothman, T. P. (1993) · Journal of Neurobiology · doi:10.1002/neu.480240207 · Cited by 241 · see citing works
Pathology of human intestinal transplantation
Rg, L., Nakamura, K., Tsamandas, A. C., Abu-Elmagd, K. M., Furukawa, H., Hutson, W., Reyes, J. D., Tabasco-Minguillan, J., Todo, S., & Aj, D. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8964408 · Cited by 240 · see citing works
Study of the interstitial cells of Cajal in infantile hypertrophic pyloric stenosis
Vanderwinden, J., Liu, H., LAET, M. H. D., & Vanderhaeghen, J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690192 · Cited by 238 · see citing works
Pathology of neuromuscular disorders of the small intestine and colon
Krishnamurthy, S., & Schuffler, M. D. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90926-7 · Cited by 235 · see citing works
Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence
Blaugrund, E., Pham, T. D., Tennyson, V. M., Lo, L., Sommer, L., Anderson, D. J., & Gershon, M. D. (1996) · Development · doi:10.1242/dev.122.1.309 · Cited by 229 · see citing works
Glutamatergic Enteric Neurons
Liu, M., Rothstein, J. D., Gershon, M. D., & Kirchgessner, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04764.1997 · Cited by 224 · see citing works
Studies on the mechanism of bowel disturbance in ulcerative colitis
Rao, S. S. C., Read, N. W., Brown, C., Bruce, C., & Holdsworth, C. D. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90554-3 · Cited by 215 · see citing works
Biofeedback provides long term benefit for patients with intractable, slow and normal transit constipation
Chiotakakou-Faliakou, E., Kamm, M. A., Roy, A. J., Storrie, J. B., & Turner, I. C. (1998) · Gut · doi:10.1136/gut.42.4.517 · Cited by 209 · see citing works
Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice
Barbara, G., Vallance, B. A., & Collins, S. M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9322517 · Cited by 205 · see citing works
Enteric neuron numbers and sizes in Auerbach's plexus in the small and large intestine of adult and aged rats
Santer, R. M., & Baker, D. (1988) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(88)90008-2 · Cited by 204 · see citing works
Neurochemical coding in the small intestine of patients with Crohn's disease.
Belai, A., Boulos, P. B., Robson, T., & Burnstock, G. (1997) · Gut · doi:10.1136/gut.40.6.767 · Cited by 202 · see citing works
Impaired expression of nitric oxide synthase in the gastric myenteric plexus of spontaneously diabetic rats
Takahashi, T., Nakamura, K., Itoh, H., Sima, A., & Owyang, C. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352855 · Cited by 201 · see citing works
Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system
Lamballe, F., Smeyne, R., & Barbacid, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00014.1994 · Cited by 199 · see citing works
Neural actions of immunophilin ligands
Snyder, S. H., Sabatini, D. M., Lai, M. M.-S., Steiner, J. P., Hamilton, G. S., & Suzdak, P. D. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01146-2 · Cited by 198 · see citing works
Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: Relationship to the development of enteric neurons
Baetge, G., & Gershon, M. D. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90217-0 · Cited by 192 · see citing works
A Preliminary Investigation of the Effects of Aging on the Nerve Cell Number in the Myenteric Ganglia of the Human Colon
Gomes, O. A., de Souza, R. R., & Liberti, É. A. (2009) · Gerontology · doi:10.1159/000213852 · Cited by 192 · see citing works
Fall in the number of myenteric neurons in aging guinea pigs
Gabella, G. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90516-7 · Cited by 187 · see citing works
Neuron size and number in the myenteric plexus of the newborn and adult rat.
Gabella, G. (1971) · PubMed · Cited by 175 · see citing works
Lack of vasoactive intestinal polypeptide nerves in esophageal achalasia
Aggestrup, S., Uddman, R., Sundler, F., Fahrenkrug, J., Håkanson, R., Sørensen, H. R., & Hambraeus, G. M. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90192-0 · Cited by 168 · see citing works
Characterization of vagal pathways mediating gastric accommodation reflex in rats
Takahashi, T., & Owyang, C. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.479be.x · Cited by 163 · see citing works
Intestinal gas dynamics and tolerance in humans
Serra, J., Azpiroz, F., & Malagelada, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70133-7 · Cited by 163 · see citing works
Notable postnatal alterations in the myenteric plexus of normal human bowel
Wester, T., O’Briain, D. S., & Puri, P. (1999) · Gut · doi:10.1136/gut.44.5.666 · Cited by 163 · see citing works
Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease [published erratum appears in Hum Mol Genet 1998 Oct;7(11):1831]
Doray, B. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1449 · Cited by 158 · see citing works
Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: Precursors of noncatecholaminergic enteric neurons
Baetge, G., Pintar, J. E., & Gershon, M. D. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90391-u · Cited by 155 · see citing works
Effects of Biofeedback Therapy on Anorectal Function in Obstructive Defecation
Rao, S. S. C., Welcher, K., & Pelsang, R. E. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018846113210 · Cited by 151 · see citing works
Previous inflammation alters the response of the rat colon to stress
Collins, S. M., McHugh, K., Jacobson, K., Khan, I., Riddell, R. H., Murase, K., & Weingarten, H. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70012-4 · Cited by 148 · see citing works
Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat
Jacobson, K., McHugh, K., & Collins, S. M. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90378-x · Cited by 144 · see citing works
Implications of Tachykinins and Calcitonin Gene-Related Peptide in Inflammatory Bowel Disease
Holzer, P. D. (1998) · Digestion · doi:10.1159/000007504 · Cited by 144 · see citing works
De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease
Ivanchuk, S. M. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.12.2023 · Cited by 144 · see citing works
Paraneoplastic visceral neuropathy as a cause of severe gastrointestinal motor dysfunction
Chinn, J. S., & Schuffler, M. D. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90362-9 · Cited by 140 · see citing works
Effects of kappa opioids in the inflamed rat colon
Sengupta, N. J., Snider, A., Su, X., & Gebhart, F. (1999) · Pain · doi:10.1016/s0304-3959(98)00175-4 · Cited by 137 · see citing works
Synthetic functions of airway smooth muscle in asthma
Johnson, S. R., & Knox, A. J. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01092-4 · Cited by 134 · see citing works
Size of neurons and glial cells in the enteric ganglia of mice, guinea-pigs, rabbits and sheep
Gabella, G., & Trigg, P. (1984) · Journal of Neurocytology · doi:10.1007/bf01148318 · Cited by 134 · see citing works
Enteric mechanisms of initiation of migrating myoelectric complexes in dogs
Sarna, S. K., Condon, R. E., & Cowles, V. E. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90151-8 · Cited by 133 · see citing works
Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation
Cortesini, C., Cianchi, F., Infantino, A., & Lise, M. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02063253 · Cited by 132 · see citing works
Plasticity of Na+ Channels in Afferent Neurones Innervating Rat Urinary Bladder Following Spinal Cord Injury
Yoshimura, N., & de Groat, W. C. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.269bh.x · Cited by 131 · see citing works
Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease
Milner, P., CROWE, R., Kamm, M. A., Lennard-Jones, J. E., & Burnstock, G. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90953-x · Cited by 129 · see citing works
Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's disease
Vanderwinden, J., LAET, M. H. D., Schiffmann, S. N., Mailleux, P., Lowenstein, C. J., Snyder, S. H., & Vanderhaeghen, J.-J. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90938-9 · Cited by 124 · see citing works
Size of neurons and glial cells in the intramural ganglia of the hypertrophic intestine of the guinea-pig
Gabella, G. (1984) · Journal of Neurocytology · doi:10.1007/bf01148319 · Cited by 121 · see citing works
Progressive changes in adrenergic, serotonergic, and peptidergic nerves in proximal colon of streptozotocin-diabetic rats
Belai, A., Lincoln, J., Milner, P., & Burnstock, G. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90356-3 · Cited by 116 · see citing works
Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia
Chalazonitis, A., Rothman, T. P., Chen, J., Lamballe, F., Barbacid, M., & Gershon, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06571.1994 · Cited by 116 · see citing works
Immunohistochemical localization of 3',5'-cyclic guanosine monophosphate in the canine proximal colon: Responses to nitric oxide and electrical stimulation of enteric inhibitory neurons
Shuttleworth, C. W., Xue, C., Ward, S. M., de Vente, J., & Sanders, K. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90350-o · Cited by 115 · see citing works
Chronic Morphine Augments Adenylyl Cyclase Phosphorylation: Relevance to Altered Signaling during Tolerance/Dependence
Chakrabarti, S., Wang, L., Tang, W., & Gintzler, A. R. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.6.949 · Cited by 111 · see citing works
Rectal biopsy for diagnosis of intestinal neuronal dysplasia in children: a prospective multicentre study on interobserver variation and clinical outcome
Koletzko, S., Jesch, I., Faus-Keler, T., Briner, J., Meier‐Ruge, W., Müntefering, H., Coerdt, W., Wessel, L., Keller, K. M., Nützenadel, W., et al. (1999) · Gut · doi:10.1136/gut.44.6.853 · Cited by 111 · see citing works
Anti-Myenteric Neuronal Antibodies in Patients with Achalasia (A Prospective Study)
Verne, G. N., Sallustio, J. E., & Eaker, E. Y. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018857617115 · Cited by 110 · see citing works
Localization of neurotrophins and their high-affinity receptors during human enteric nervous system development
Hoehner, J., Wester, T., Påhlman, S., & Olsen, L. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8608885 · Cited by 107 · see citing works
Neurotrophin release by neurotrophins: Implications fro activity dependent neurons.
Canossa, M. (1997) · Medical Entomology and Zoology · Cited by 106 · see citing works
Heteroreceptor-mediated modulation of noradrenaline and acetylcholine release from peripheral nerves
FUDER, H., & Muscholl, E. (2006) · Springer eBooks · doi:10.1007/bfb0049778 · Cited by 104 · see citing works
Neuropeptides in idiopathic chronic constipation (slow transit constipation)
Sjölund, K., Fasth, S., Ekman, R., Hultén, L., Jiborn, H., Nordgren, S., & Sundler, F. (1997) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1997.d01-46.x · Cited by 103 · see citing works
Intrinsic connections in the macaque inferior temporal cortex
Fujita, I., & Fujita, T. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960513)368:4 · Cited by 103 · see citing works
Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle
Cocks, T. M., Sozzi, V., Moffatt, J. D., & Selemidis, S. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70180-0 · Cited by 103 · see citing works
Nerve growth factor supply for sensory neurons: Site of origin and competition with the sympathetic nervous system
Korsching, S. I., & Thoenen, H. (1985) · Neuroscience Letters · doi:10.1016/s0304-3940(85)80079-3 · Cited by 102 · see citing works
Enteric neuronal plasticity and a reduced number of interstitial cells of Cajal in hypertrophic rat ileum
Ekblad, E., Sjuve, R., Arner, A., & Sundler, F. (1998) · Gut · doi:10.1136/gut.42.6.836 · Cited by 100 · see citing works
Antimyenteric neuronal antibodies in scleroderma.
HOWE, S. E., Eaker, E. Y., Sallustio, J. E., Peebles, C., Tan, E. M., & Williams, R. C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117395 · Cited by 100 · see citing works
Excitotoxicity in the Enteric Nervous System
Kirchgessner, A. L., Liu, M., & Alcantara, F. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-22-08804.1997 · Cited by 97 · see citing works
Hirschsprung’s disease: genetic mutations in mice and men
Robertson, K. E., Mason, I. J., & Hall, S. D. (1997) · Gut · doi:10.1136/gut.41.4.436 · Cited by 92 · see citing works
Plasticity in adult and ageing sympathetic neurons
Cowen, T., & Gavazzi, I. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00071-3 · Cited by 91 · see citing works
Desensitization of the Neurokinin-1 Receptor (NK1-R) in Neurons: Effects of Substance P on the Distribution of NK1-R, Gαq/11, G-Protein Receptor Kinase-2/3, and β-Arrestin-1/2
McConalogue, K., Corvera, C. U., Gamp, P. D., Grady, E. F., & Bunnett, N. W. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.8.2305 · Cited by 90 · see citing works
Abnormalities of nerve fibers in the circular muscle of patients with slow transit constipation
Porter, A. J., Wattchow, D. A., Hunter, A., & Costa, M. (1998) · International Journal of Colorectal Disease · doi:10.1007/s003840050163 · Cited by 89 · see citing works
Adrenergic mechanisms in the control of gastrointestinal motility: From basic science to clinical applications
Ponti, F. D., Giaroni, C., Cosentino, M., Lecchini, S., & Frigo, G. M. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02031-4 · Cited by 89 · see citing works
Self-citation
Migration of the myoelectric complex after interruption of the myenteric plexus: Intestinal transection and regeneration of enteric nerves in the guinea pig
Galligan, J. J., Furness, J. B., & Costa, M. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91683-1 · Cited by 84 · see citing works
Activation and internalization of the μ-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2
McConalogue, K., Grady, E. F., Minnis, J., Balestra, B., Tonini, M., Brecha, N. C., Bunnett, N. W., & Sternini, C. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00514-4 · Cited by 82 · see citing works
Endocytosis and recycling of neurokinin 1 receptors in enteric neurons
Grady, E. F., Gamp, P. D., Jones, E. F., Bałuk, P., McDonald, D. M., Payan, D. G., & Bunnett, N. W. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00357-0 · Cited by 81 · see citing works
Neurochemical differentiation of rat enteric neurons during pre- and postnatal life
Matini, P., Mayer, B., & Faussone‐Pellegrini, M. S. (1997) · Cell and Tissue Research · doi:10.1007/s004410050788 · Cited by 79 · see citing works
Regulation of neuropeptide expression in the brain by neurotrophins
Carnahan, J. F., & Nawa, H. (1995) · Molecular Neurobiology · doi:10.1007/bf02740672 · Cited by 77 · see citing works
Dynamic Gastric Response to Expansion before and after Vagotomy
Jahnberg, T., Martinson, J., Hultén, L., & Fasth, S. (1975) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1975.12097017 · Cited by 76 · see citing works
Abnormalities in the distribution of laminin and collagen type IV in Hirschsprung's disease
Parikh, D., Tam, P. K. H., van Velzen, D., & Edgar, D. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)70018-7 · Cited by 74 · see citing works
Biofeedback Is Effective Therapy for Fecal Incontinence and Constipation
Ko, C. Y. (1997) · Archives of Surgery · doi:10.1001/archsurg.1997.01430320031004 · Cited by 72 · see citing works
Functional Gut Disorders
Ponti, F. D., & Malagelada, J. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00021-7 · Cited by 71 · see citing works
Chronic morphine augments G(beta)(gamma)/Gs(alpha) stimulation of adenylyl cyclase: relevance to opioid tolerance.
Chakrabarti, S., Rivera, M., Yan, S.-Z., Tang, W., & Gintzler, A. R. (1998) · PubMed · Cited by 71 · see citing works
Factors Affecting Outcome Following Proximal and Distal Intestinal Resection in the Dog (An Examination of the Relative Roles of Mucosal Adaptation, Motility, Luminal Factors, and Enteric Peptides)
Thompson, J. S., Quigley, E. M. M., & Adrian, T. E. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026697915937 · Cited by 70 · see citing works
On the plasticity of form and structure of enteric ganglia
Gabella, G. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90103-p · Cited by 69 · see citing works
Distribution of growth-associated protein, B-50 (GAP-43) in the mammalian enteric nervous system
Sharkey, K. A., Coggins, P. J., Tetzlaff, W., Zwiers, H., Bisby, M. A., & Js, D. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90370-j · Cited by 69 · see citing works
Some observations on the intrinsic nervous mechanism in Hirschsprung's disease
Frigo, G. M., Tacca, M. D., Lecchini, S., & Crema, A. (1973) · Gut · doi:10.1136/gut.14.1.35 · Cited by 69 · see citing works
Self-citation
Tachykinins as transmitters of ascending contractile component of the peristaltic reflex
Grider, J. R. (1989) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1989.257.5.g709 · Cited by 66 · see citing works
The pathology of infantile hypertrophic pyloric stenosis after healing
Vanderwinden, J., Liu, H., Menu, R., Conreur, J.-L., LAET, M. H. D., & Vanderhaeghen, J. J. (1996) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(96)90171-2 · Cited by 66 · see citing works
The origin of synaptic neuroplasticity: crucial molecules or a dynamical cascade?
Shaw, C. A., Lanius, R. A., & van den Doel, K. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90014-0 · Cited by 64 · see citing works
Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease
Bär, K., Facer, P., Williams, N. S., Tam, P., & Anand, P. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70154-9 · Cited by 64 · see citing works
Ageing in the autonomic nervous system: A result of nerve-target interactions? A review
Cowen, T. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90148-k · Cited by 63 · see citing works
Long-term effects of synaptic activation at low frequency on excitability of myenteric AH neurons
Clerc, N., Furness, J. B., Kunze, W. A. A., Thomas, E. A., & Bertrand, P. P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00431-x · Cited by 63 · see citing works
The myenteric plexus regulates cell growth in rat jejunum
See, N. A., Epstein, M. L., Dahl, J. L., & Bass, P. (1990) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(90)90188-o · Cited by 61 · see citing works
Identification of neurons that express stem cell factor in the mouse small intestine
Young, H. M., Torihashi, S., Ciampoli, D., & Sanders, K. M. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70262-8 · Cited by 59 · see citing works
Downregulation of neutral endopeptidase (EC 3.4.24.11) in the inflamed rat intestine
Hwang, L. H., Leichter, R. F., Okamoto, A., Payan, D. G., Collins, S. M., & Bunnett, N. W. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.264.4.g735 · Cited by 59 · see citing works
A1-Receptor-mediated effect of adenosine on the release of acetylcholine from the myenteric plexus: Role and localization of ecto-ATPase and 5′-nucleotidase
Nitahara, K., Kittel, Á., Liang, S., & Vizi, E. S. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00585-s · Cited by 58 · see citing works
A novel neuroendocrine gene product: selective VGF8a gene expression and immuno-localisation of the VGF protein in endocrine and neuronal populations
Ferri, G., Levi, A., & Possenti, R. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90053-e · Cited by 58 · see citing works
HumanGFRA1: Cloning, Mapping, Genomic Structure, and Evaluation as a Candidate Gene for Hirschsprung Disease Susceptibility
Angrist, M. H., Jing, S., Gabriel, S., Bentley, K., Nallasamy, S., Halushka, M. K., Fox, G. M., & Chakravarti, A. (1998) · Genomics · doi:10.1006/geno.1997.5191 · Cited by 58 · see citing works
Pharmacological evidence that nitric oxide may be a retrograde messenger in the enteric nervous system
Yuan, S., Bornstein, J. C., & Furness, J. B. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13244.x · Cited by 54 · see citing works
Altered myoelectrical activity in noninflamed ileum of rats with colitis induced by trinitrobenzene sulphonic acid
Aube, A. C., CHERBUT, Barbier, Xing, Roze, V., & Galmiche (1999) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1999.00137.x · Cited by 53 · see citing works
Peripheral Effects of Opioids in a Model of Chronic Intestinal Inflammation in Mice
Puig, M. M., & Pol, O. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37902-9 · Cited by 53 · see citing works
p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)‐associated protein kinase.
Canossa, M., Twiss, J. L., Verity, A. N., & Shooter, E. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00702.x · Cited by 52 · see citing works
Changes in surviving nerve fibers associated with submucosal arteries following extrinsic denervation of the small intestine
Galligan, J. J., Costa, M., & Furness, J. B. (1988) · Cell and Tissue Research · doi:10.1007/bf00219756 · Cited by 51 · see citing works
Sensitivities of the isolated ileal longitudinal smooth muscle-myenteric plexus and hypogastric nerve-vas deferens of the guinea pig after chronic morphine pellet implantation.
Johnson, S. M., Westfall, D. P., Howard, S. A., & Fleming, W. W. (1978) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31112-2 · Cited by 51 · see citing works
Autocrine regulation of growth in cultured human intestinal muscle by growth factors
Kuemmerle, J. F. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70176-8 · Cited by 50 · see citing works
Characterisation of substance P-induced endocytosis of NK1 receptors on enteric neurons
Southwell, B. R., Woodman, H. L., Murphy, R., Royal, S. J., & Furness, J. B. (1996) · Histochemistry and Cell Biology · doi:10.1007/bf02473271 · Cited by 49 · see citing works
Mammalian glial cells in culture synthesize acetylcholine
Wessler, I. K., Reinheimer, T. M., Klapproth, H., Schneider, F.-J., Racké, K., & Hammer, R. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005107 · Cited by 48 · see citing works
MODIFICATION OF HUMAN GASTRIC ACID SECRETION WITH OPERANT‐CONDITIONING PROCEDURES1
Whitehead, W. E., Renault, P. F., & Goldiamond, I. (1975) · Journal of Applied Behavior Analysis · doi:10.1901/jaba.1975.8-147 · Cited by 48 · see citing works
Mediation by Protein Kinases C and A of Go-Linked Slow Responses of Enteric Neurons to 5-HT
Pan, H., Wang, H.-Y., Friedman, E., & Gershon, M. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-01011.1997 · Cited by 45 · see citing works
Neuroplasticity in the smooth muscle of the myenterically and extrinsically denervated rat jejunum
Luck, M. S., Dahl, J. L., Boyeson, M. G., & Bass, P. (1993) · Cell and Tissue Research · doi:10.1007/bf00318623 · Cited by 44 · see citing works
Correlations between electrophysiological observations of synaptic plasticity modifications and behavioral performance in mammals
Roman, F. S., Truchet, B., Marchetti, E., Chaillan, F. A., & Soumireu-Mourat, B. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00076-8 · Cited by 43 · see citing works
Modulation of dye coupling among glial cells in the myenteric and submucosal plexuses of the guinea pig
MAUDLEJ, N., & Hanani, M. (1992) · Brain Research · doi:10.1016/0006-8993(92)90234-z · Cited by 43 · see citing works
Abnormal Motility of the Small Intestine in Ulcerative Colitis
Manousos, O. N., & Salem, S. (2009) · Gastroenterologia · doi:10.1159/000202102 · Cited by 43 · see citing works
GDNF is abundant in the adult rat gut
Peters, R. J., Osinski, M. A., Hongo, J.-A. S., Bennett, G. L., Okragly, A. J., Haak‐Frendscho, M., & Epstein, M. L. (1998) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(98)00044-7 · Cited by 43 · see citing works
Growth factors and the development and plasticity of the enteric nervous system
Saffrey, M. J., & Burnstock, G. (1994) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)90165-1 · Cited by 43 · see citing works
GDNF deficit in Hirschsprung's disease
Martucciello, G., Thompson, H. L., MAZZOLA, C., Morando, A. E. S., Bertagnon, M., Negri, F., Brizzolara, A., Rocchetti, L., Gambini, C., & Jasonni, V. (1998) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(98)90371-2 · Cited by 42 · see citing works
The nerve growth factor receptor gene is expressed in both neuronal and non‐neuronal tissues in the human fetus
Ernfors, P., Wetmore, C., Eriksdotter, M., Bygdeman, M., Strömberg, I., Olson, L., & Persson, H. (1991) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(91)90073-u · Cited by 41 · see citing works
Effect of growth factors on substance P mRNA expression in axotomized dorsal root ganglia
Zhang, Q., Ji, R., Lindsay, R. M., & Hökfelt, T. G. M. (1995) · Neuroreport · doi:10.1097/00001756-199506090-00020 · Cited by 40 · see citing works
Somatostatin‐mediated inhibitory postsynaptic potential in sympathetically denervated guinea‐pig submucosal neurones.
Shen, K., & Surprenant, A. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019878 · Cited by 39 · see citing works
Alterations in neurotrophin and neurotrophin-receptor localization in Hirschsprung's disease
Hoehner, J. C., Wester, T., Påhlman, S., & Olsen, L. (1996) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(96)90170-0 · Cited by 39 · see citing works
Capacitative Ca2+entry in enteric glia induced by thapsigargin and extracellular ATP
Sarosi, G. A., Barnhart, D. C., Turner, D. J., & Mulholland, M. W. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.3.g550 · Cited by 38 · see citing works
Glial-cell-line-derived neurotrophic factor enhances biosynthesis of substance P in striatal neurons in vitro
Humpel, C., Marksteiner, J., & Saria, A. (1996) · Cell and Tissue Research · doi:10.1007/s004410050694 · Cited by 37 · see citing works
Movement of villi induces endocytosis of NK1 receptors in myenteric neurons from guinea-pig ileum
Southwell, B. R., Woodman, H. L., Royal, S. J., & Furness, J. B. (1998) · Cell and Tissue Research · doi:10.1007/s004410051032 · Cited by 37 · see citing works
Is intestinal neuronal dysplasia a disorder of the neuromuscular junction?
Kobayashi, H., Hirakawa, H., & Puri, P. S. (1996) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(96)90500-x · Cited by 34 · see citing works
Extrinsic denervation increases NADPH diaphorase staining in myenteric nerves of guinea pig ileum
Yunker, A. M. R., & Galligan, J. J. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91025-1 · Cited by 33 · see citing works
Tachykinins as transmitters of ascending contractile component of the peristaltic reflex
Grider, J. R. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.258.4.1-a · Cited by 33 · see citing works
Editorial
Naliboff, B. D., Munakata, J., Chang, L., & Mayer, E. A. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00049-x · Cited by 32 · see citing works
Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig
Sharkey, K. A., Parr, E. J., & Keenan, C. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02755.1999 · Cited by 31 · see citing works
Glial cells participate in histamine inactivation in vivo
Huszti, Z., Prast, H., Tran, M. H., Fischer, H., & Philippu, A. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005137 · Cited by 29 · see citing works
EXTRINSIC SYMPATHETIC REINNERVATION AFTER INTESTINAL TRANSPLANTATION IN RATS
Kiyochi, H., ONO, A., Yamamoto, N., Ohnishi, K., Shimahara, Y., & Kobayashi, N. (1995) · Transplantation · doi:10.1097/00007890-199502000-00004 · Cited by 29 · see citing works
Nuclear Fos immunoreactivity in guinea pig myenteric neurons following activation of motor activity
Ritter, R. C., Costa, M., & Brookes, S. J. H. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g498 · Cited by 28 · see citing works
Changes in sensitivity to the inhibitory effects of adrenergic agonists on intestinal motor activity after chronic sympathetic denervation
Frigo, G. M., Lecchini, S., Marcoli, M., Tonini, M., D'Angelo, L., & Crema, A. (1984) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00506194 · Cited by 28 · see citing works
Self-citation
Depressant effects of hypoxia and hypoglycaemia on neuro‐effector transmission of guinea‐pig intestine studied in vitro with a pharmacological model
Corbett, A. D., & Lees, G. M. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700870 · Cited by 27 · see citing works
Use of synaptophysin polyclonal antibody for the rapid intraoperative immunohistochemical evaluation of functional bowel disorders
Kobayashi, H., Miyano, T., Yamataka, A., Lane, G. J., Fujimoto, T., & Puri, P. (1997) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(97)90088-9 · Cited by 27 · see citing works
Neurotransmitters modulate cytokine-stimulated interleukin 6 secretion in rat intestinal smooth muscle cells
Assche, G. V., Barbara, G., Deng, Y., Lovato, P., Gauldie, J., & Collins, S. M. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70131-9 · Cited by 27 · see citing works
Nerve growth factor receptor immunostaining suggests an extrinsic origin for hypertrophic nerves in Hirschsprung's disease.
Kobayashi, H., O’Briain, D. S., & Puri, P. (1994) · Gut · doi:10.1136/gut.35.11.1605 · Cited by 27 · see citing works
Adrenergic Denervation Hypersensitivity in Ileal Circular Smooth Muscle After Small Bowel Transplantation in Rats
Shibata, C., Balsiger, B. M., Anding, W. J., & Sarr, M. G. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018850214119 · Cited by 27 · see citing works
Evidence that Tolerance and Dependence of Guinea Pig Myenteric Neurons to Opioids Is a Function of Altered Electrogenic Sodium-Potassium Pumping
Kong, J., Leedham, J. A., TAYLOR, D. A. H. B., & Fleming, W. W. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36425-0 · Cited by 25 · see citing works
Morphine tolerance and nonspecific subsensitivity of the longitudinal muscle myenteric plexus preparation of the guinea-pig to inhibitory agonists
Taylor, D. A., Leedham, J. A., Doak, N., & Fleming, W. W. (1988) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00179329 · Cited by 25 · see citing works
Innervation of the rat gastrointestinal sphincters: Changes during development and aging
Belai, A., Wheeler, H., & Burnstock, G. (1995) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(95)00005-2 · Cited by 25 · see citing works
Can the intestine adapt to a changing environment?
Thompson, J. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.agast971131402 · Cited by 25 · see citing works
Effect of Reversed Intestinal Segments on Intestinal Structure and Function
Thompson, J. S., Quigley, E. M. M., Adrian, T. E., & Pathol., M. R. C. (1995) · Journal of Surgical Research · doi:10.1006/jsre.1995.1004 · Cited by 24 · see citing works
Gastrointestinal neuropeptide concentrations following guanethidine sympathectomy
Nelson, D. K., Service, J., Studelska, D. R., Brimijoin, S., & Go, V. L. W. (1988) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(88)90108-7 · Cited by 24 · see citing works
Extrinsic denervation increases myenteric nitric oxide synthase-containing neurons and inhibitory neuromuscular transmission in guinea pig
Yunker, A. M. R., & Galligan, J. J. (1998) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(98)00074-5 · Cited by 23 · see citing works
Altered production of nerve growth factor in aganglionic intestines
Kuroda, T., Ueda, M., Nakano, M., & Saeki, M. (1994) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(94)90334-4 · Cited by 23 · see citing works
Peptidergic nerves persist after jejunal autotransplantation: An experimental study in the piglet
Malmfors, G., Håkanson, R., Okmian, L., & Sundler, F. (1980) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(80)80403-9 · Cited by 23 · see citing works
Immunohistochemical study of enteric nervous system after small bowel transplantation in humans
Sugitani, A., Reynolds, J. C., & Todo, S. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087666 · Cited by 22 · see citing works
Functional Anatomy of the Enteric Nervous System
Gershon, M. D., & Nakamura, H. (2019) · Springer eBooks · doi:10.1007/978-3-030-15647-3_3 · Cited by 22 · see citing works
Activity-dependent changes in intracellular calcium in myenteric neurons
Menachem Hanani, A., & Lasser‐Ross, N. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.6.g1359 · Cited by 21 · see citing works
Nerve growth factor promotes neurite outgrowth in guinea pig myenteric plexus ganglia
Mulholland, M. W., Romanchuk, G. L., Lally, K. M., & Simeone, D. M. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.4.g716 · Cited by 21 · see citing works
c-Fos- and JunB- immunoreactivities in the enteric nervous system of the guinea-pig ileum
Parr, E. J., & Sharkey, K. A. (1994) · Neuroreport · doi:10.1097/00001756-199408150-00029 · Cited by 20 · see citing works
Overexpression of intercellular adhesion molecule-1 (ICAM-1) and MHC class II antigen on hypertrophic nerve trunks suggests an immunopathologic response in Hirschsprung's disease
Kobayashi, H., Hirakawa, H., & Puri, P. (1995) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(95)90451-4 · Cited by 19 · see citing works
Subsensitivity of enteric cholinergic neurones to α2-adrenoceptors agonists after chronic sympathetic denervation
Marcoli, M., Lecchini, S., Ponti, F. D., D'Angelo, L., Crema, A., & Frigo, G. M. (1985) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00501879 · Cited by 19 · see citing works
Self-citation
Expression of immediate early genes in rat gastric myenteric neurones: a physiological response to feeding.
Dimaline, R., Miller, S. M., Evans, D., Noble, P. J., Brown, P., & Poat, J. A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020983 · Cited by 18 · see citing works
Tonic modulation of neurotransmitter release in the guinea-pig myenteric plexus: effect of μ and κ opioid receptor blockade and of chronic sympathetic denervation
Cosentino, M., Marino, F., Ponti, F. D., Giaroni, C., Somaini, L., Leoni, O., Lecchini, S., & Frigo, G. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11757-n · Cited by 18 · see citing works
Self-citation
Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus.
Ammer, H., Nice, L., Lang, J., & Schulz, R. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20332-9 · Cited by 18 · see citing works
Reduced glial cell line-derived neurotrophic factor level in aganglionic bowel in Hirschsprung's disease
Ohshiro, K., & Puri, P. (1998) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(98)90671-6 · Cited by 17 · see citing works
Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation
Goldhill, J., Shea‐Donohue, T., Ali, N., & Piñeiro-Carrero, V. M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36953-8 · Cited by 17 · see citing works
Gastric adaptive relaxation and symptoms after vagotomy
Hartley, M., & Mackie, C. R. (1991) · British journal of surgery · doi:10.1002/bjs.1800780109 · Cited by 17 · see citing works
Changes in Muscularis Externa of Rat Small Intestine After Myenteric Ablation with Benzalkonium Chloride: Electron Microscopic and Morphometric Study
Holle, G. E. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1026603327807 · Cited by 16 · see citing works
Intercellular communication between dorsal root ganglion cells and colonic smooth muscle cells in vitro
Ennes, H. S., Young, S. H., Raybould, H. E., & Mayer, E. A. (1997) · Neuroreport · doi:10.1097/00001756-199702100-00031 · Cited by 16 · see citing works
Growth of myenteric plexus explant cultures in a serum‐free, hormone‐supplemented culture medium
Saffrey, M. J., & Burnstock, G. (1984) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(84)90037-6 · Cited by 16 · see citing works
Neurokinin 3 receptors in the gut: A new target for the treatment of visceral pain?
Mayer, E. A., & Marvizón, J. C. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70030-2 · Cited by 16 · see citing works
Chronic rejection causes early destruction of the intrinsic nervous system in rat intestinal transplants
Heeckt, P. F., Halfter, W. M., Schraut, W. H., & Bauer, A. J. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g413 · Cited by 16 · see citing works
Neural Injury, Repair, and Adaptation in the GI Tract V. Genes, lineages, and tissue interactions in the development of the enteric nervous system *
Gershon, M. D. (1998) · Cited by 15 · see citing works
Neuronal intestinal dysplasia.
Ryan, D. P. (1995) · PubMed · Cited by 15 · see citing works
Re-innervation of submucosal arterioles by myenteric neurones following extrinsic denervation
Jiang, M., & Surprenant, A. (1992) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(92)90243-a · Cited by 14 · see citing works
Leukemia inhibitory factor mediates cytokine-induced suppression of myenteric neurotransmitter release from rat intestine
Assche, G. V., & Collins, S. M. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8780572 · Cited by 13 · see citing works
Post-stimulus depression of reflex changes in circular muscle activity in the guinea pig small intestine
Yuan, S., Furness, J. B., & Bornstein, J. C. (1992) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(92)90198-p · Cited by 13 · see citing works
Muscarinic Autoinhibition and Modulatory Role of Protein Kinase C in Acetylcholine Release from the Myenteric Plexus of Guinea Pig Ileum
Saitoh, N., Fujimoto, R., Ishii, T., Nishio, H., Takeuchi, T., & Hata, F. (1997) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)31404-0 · Cited by 13 · see citing works

Flagged first, then by citations

3 of the 226 references couldn’t be matched to a known paper.

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Enteric neuroplasticity evoked by inflammation
Vasina, V., Barbara, G., Talamonti, L., Stanghellini, V., Corinaldesi, R., Tonini, M., De Ponti, F., & De Giorgio, R. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.025 · Cited by 221 · see citing works
Enteric Nervous System: Development and Developmental Disturbances—Part 1
Newgreen, D. F., & Young, H. M. (2002) · Pediatric and Developmental Pathology · doi:10.1007/s10024-001-0142-y · Cited by 205 · see citing works
Mast cell tryptase and proteinase‐activated receptor 2 induce hyperexcitability of guinea‐pig submucosal neurons
Reed, D. E., Barajas‐Lopez, C., Cottrell, G., Velazquez‐Rocha, S., Dery, O., Grady, E. F., Bunnett, N. W., & Vanner, S. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032011 · Cited by 192 · see citing works
The gut microbiome restores intrinsic and extrinsic nerve function in germ‐free mice accompanied by changes in calbindin
McVey Neufeld, K. A., Perez‐Burgos, A., Mao, Y. K., Bienenstock, J., & Kunze, W. A. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12534 · Cited by 142 · see citing works
Correlation of electrophysiological and morphological characteristics of enteric neurons in the mouse colon
Nurgali, K., Stebbing, M. J., & Furness, J. B. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10948 · Cited by 132 · see citing works
Increased mucosal nitric oxide production in ulcerative colitis is mediated in part by the enteroglial‐derived S100B protein
Cirillo, C., Sarnelli, G., Esposito, G., Grosso, M., Petruzzelli, R., Izzo, P., Calı̀, G., D’Armiento, F. P., Rocco, A., Nardone, G., et al. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01346.x · Cited by 129 · see citing works
Enteric neural crest-derived cells: Origin, identification, migration, and differentiation
Young, H. M., & Newgreen, D. F. (2001) · The Anatomical Record · doi:10.1002/1097-0185(20010101)262:1 · Cited by 163 · see citing works
Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease
Filpa, V., Moro, E., Protasoni, M., Crema, F., Frigo, G., & Giaroni, C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.024 · Cited by 121 · see citing works
Self-citation
Enteric Glial-Derived S100B Protein Stimulates Nitric Oxide Production in Celiac Disease
Esposito, G., Cirillo, C., Sarnelli, G., Filippis, D. D., D’Armiento, F. P., Rocco, A., Nardone, G., Petruzzelli, R., Grosso, M., Izzo, P., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.009 · Cited by 107 · see citing works
Enteric glial cells: new players in gastrointestinal motility?
Bassotti, G., Villanacci, V., Antonelli, E., Morelli, A., & Salerni, B. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700564 · Cited by 107 · see citing works
Neurons and Glia in the Enteric Nervous System and Epithelial Barrier Function
Vergnolle, N., & Cirillo, C. (2018) · Physiology · doi:10.1152/physiol.00009.2018 · Cited by 106 · see citing works
Isolation and characterization of a plant growth-promoting rhizobacterium, Serratia sp. SY5.
Koo, S.-Y., & Cho, K.-S. (2009) · PubMed · Cited by 90 · see citing works
The microbiota-gut-brain axis: Focus on the fundamental communication pathways
Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 88 · see citing works
Self-citation
Morphological and Functional Alterations of the Myenteric Plexus in Rats with TNBS-Induced Colitis
Poli, E., Lazzaretti, M., Grandi, D., Pozzoli, C., & Coruzzi, G. (2001) · Neurochemical Research · doi:10.1023/a:1012313424144 · Cited by 84 · see citing works
Primary Enteric Neuropathies Underlying Gastrointestinal Motor Dysfunction
GIORGIO, R. D. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750024263 · Cited by 78 · see citing works
Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by α2‐adrenoceptors in the presence of experimental colitis
Blandizzi, C., Fornai, M., Colucci, R., Baschiera, F., Barbara, G., GIORGIO, R. D., Ponti, F. D., Breschi, M. C., & Tacca, M. D. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705249 · Cited by 78 · see citing works
Prolonged high fat diet ingestion, obesity, and type 2 diabetes symptoms correlate with phenotypic plasticity in myenteric neurons and nerve damage in the mouse duodenum
Stenkamp-Strahm, C. M., Nyavor, Y., Kappmeyer, A. J., Horton, S., Gericke, M. T., & Balemba, O. B. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2132-9 · Cited by 73 · see citing works
Effects of the probiotic yeast Saccharomyces boulardii on the neurochemistry of myenteric neurones in pig jejunum
Kamm, K., Hoppe, S., Breves, G., Schröder, B., & Schemann, M. (2004) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00458.x · Cited by 70 · see citing works
The chemical code of porcine enteric neurons and the number of enteric glial cells are altered by dietary probiotics
Giancamillo, A. D., Vitari, F., Bosi, G., Savoini, G., & Domeneghini, C. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01529.x · Cited by 67 · see citing works
Plasticity and Neural Stem Cells in the Enteric Nervous System
Schäfer, K., Ginneken, C. J. V., & Copray, S. C. V. M. (2009) · The Anatomical Record · doi:10.1002/ar.21033 · Cited by 65 · see citing works
Fetal Intestinal Obstruction Induces Alteration of Enteric Nervous System Development in Human Intestinal Atresia
Khen‐Dunlop, N., Jaubert, F., Sauvat, F., Fourcade, L., Jan, D., Martinovic, J., Vekemans, M. J. J., Landais, P., Brousse, N., Leborgne, M., et al. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000145294.11800.71 · Cited by 64 · see citing works
Slow Transit Constipation: A Review of a Colonic Functional Disorder
Frattini, J. C., & Nogueras, J. J. (2008) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-2008-1075864 · Cited by 63 · see citing works
Effects of pre- and postnatal protein deprivation and postnatal refeeding on myenteric neurons of the rat large intestine: a quantitative morphological study
Castelucci, P., de Souza, R., de Angelis, R., Furness, J. B., & Liberti, É. A. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0615-y · Cited by 61 · see citing works
Neural stem cells express RET, produce nitric oxide, and survive transplantation in the gastrointestinal tract
Micci, M., Learish, R. D., Li, H., Abraham, B. P., & Pasricha, P. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.28633 · Cited by 60 · see citing works
What’s bugging your teen?—The microbiota and adolescent mental health
McVey Neufeld, K.-A., Luczynski, P., Seira Oriach, C., Dinan, T. G., & Cryan, J. F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.005 · Cited by 56 · see citing works
ChAT and NOS in human myenteric neurons: co-existence and co-absence
Beck, M., Schlabrakowski, A., Schroedl, F., Neuhuber, W., & Brehmer, A. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0852-4 · Cited by 55 · see citing works
Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors
Giaroni, C., Zanetti, E., Chiaravalli, A. M., Albarello, L., Dominioni, L., Capella, C., Lecchini, S., & Frigo, G. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02147-2 · Cited by 53 · see citing works
Self-citation
Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease from Mice to Human
Montanari, M., Imbriani, P., Bonsi, P., Martella, G., & Peppe, A. (2023) · Biomedicines · doi:10.3390/biomedicines11061560 · Cited by 49 · see citing works
Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells
zhang, M., Leung, F., Huang, Y., & Bian, Z. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01467.x · Cited by 47 · see citing works
Intraganglionic laminar endings and their relationships with neuronal and glial structures of myenteric ganglia in the esophagus of rat and mouse
Raab, M., & Neuhuber, W. (2000) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0703-z · Cited by 47 · see citing works
The gut as a neurological organ.
Holzer, P. D., Schicho, R., Holzer‐Petsche, U., & Lippe, I. T. (2001) · PubMed · Cited by 44 · see citing works
Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis
Filpa, V., Bistoletti, M., Caon, I., Moro, E., Grimaldi, A., Moretto, P., Baj, A., Giron, M. C., Karousou, E. G., Viola, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-18020-7 · Cited by 44 · see citing works
Self-citation
SOX10 is abnormally expressed in aganglionic bowel of Hirschsprung's disease infants
Sham, M. H., Lui, V. C. H., Fu, M., Chen, B., & Tam, P. K. H. (2001) · Gut · doi:10.1136/gut.49.2.220 · Cited by 43 · see citing works
Vasoactive intestinal peptide and substance P-like immunoreactivities in the enteric nervous system of the pig correlate with the severity of pathological changes induced by Schistosoma japonicum
Balemba, O. B., Semuguruka, W. D., Hay‐Schmidt, A., Johansen, M. V., & Dantzer, V. (2001) · International Journal for Parasitology · doi:10.1016/s0020-7519(01)00273-9 · Cited by 42 · see citing works
Chronic idiopathic slow transit constipation: pathophysiology and management
El-Salhy, M. (2003) · Colorectal Disease · doi:10.1046/j.1463-1318.2003.00498.x · Cited by 51 · see citing works
Drug Development for the Irritable Bowel Syndrome: Current Challenges and Future Perspectives
Ponti, F. D. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00007 · Cited by 40 · see citing works
Maintenance of the enteric stem cell niche by bacterial lipopolysaccharides? Evidence and perspectives
Schuster, A. M., Klotz, M., Schwab, T., Liddo, R. D., Bertalot, T., Schrenk, S., Martin, M., Nguyen, T. D., Nguyen, T. N. Q., Gries, M., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12292 · Cited by 39 · see citing works
Plasticity of interstitial cells of Cajal: a study of mouse colon
Faussone-Pellegrini, M., Vannucchi, M., Ledder, O., Huang, T., & Hanani, M. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0174-8 · Cited by 37 · see citing works
The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum
Avula, L. R., Buckinx, R., Alpaerts, K., Costagliola, A., Adriaensen, D., Nassauw, L. V., & Timmermans, J. (2011) · Histochemistry and Cell Biology · doi:10.1007/s00418-011-0862-7 · Cited by 35 · see citing works
Small bowel motility in functional chronic constipation
Seidl, H., Gundling, F., Pehl, C., Pfeiffer, A., Schepp, W., & Schmidt, T. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01364.x · Cited by 32 · see citing works
The Human Gastrointestinal Tract, a Potential Autologous Neural Stem Cell Source
Hagl, C., Heumüller-Klug, S., Wink, E., Wessel, L., & Schäfer, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072948 · Cited by 31 · see citing works
Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation
Chen, Z., Suntres, Z., Palmer, J. M., Guzman, J. E., Javed, A., Xue, J., Yu, J., Cooke, H. J., Awad, H., Hassanain, H. H., et al. (2007) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.12.018 · Cited by 30 · see citing works
Is DARPP-32 a potential therapeutic target?
Reis, H. J., Rosa, D. V., Guimarães, M. M., Souza, B. R., Barros, A. G. A., Pimenta, F. J., de Souza, R. P., Torres, K., & Romano‐Silva, M. A. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.12.1649 · Cited by 29 · see citing works
Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine.
Godlewski, J. (2010) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-010-0029-8 · Cited by 28 · see citing works
Interaction between NMDA glutamatergic and nitrergic enteric pathways during in vitro ischemia and reperfusion
Filpa, V., Carpanese, E., Marchet, S., Prandoni, V., Moro, E., Lecchini, S., Frigo, G., Giaroni, C., & Crema, F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.01.021 · Cited by 27 · see citing works
Self-citation
Glutamatergic Functions of Primary Afferent Neurons with Special Emphasis on Vagal Afferents
Raab, M., & Neuhuber, W. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)56007-9 · Cited by 27 · see citing works
Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig
Hons, I. M., Burda, J. E., Grider, J. R., Mawe, G. M., & Sharkey, K. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90472.2008 · Cited by 26 · see citing works
The colon revisited or the key to wellness, health and disease.
Gonzalez-Correa, C., Mulett-Vásquez, E., Miranda, D. A., González-Correa, C., & Gómez-Buitrago, P. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.07.032 · Cited by 23 · see citing works
Macrophages are unsuccessful in clearing aggregated alpha‐synuclein from the gastrointestinal tract of healthy aged Fischer 344 rats
Phillips, R. J., Billingsley, C. N., & Powley, T. L. (2013) · The Anatomical Record · doi:10.1002/ar.22675 · Cited by 26 · see citing works
Enteric nervous system and developmental abnormalities in childhood
Paran, T. S., Rolle, U., & Puri, P. (2006) · Pediatric Surgery International · doi:10.1007/s00383-006-1782-9 · Cited by 25 · see citing works
Role of neuronal and inducible nitric oxide synthases in the guinea pig ileum myenteric plexus during in vitro ischemia and reperfusion
Giaroni, C., Marchet, S., Carpanese, E., Prandoni, V., Oldrini, R., Bartolini, B., Moro, E., Vigetti, D., Crema, F., Lecchini, S., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12061 · Cited by 24 · see citing works
Self-citation
Glial regulation of neuronal plasticity in the gut: implications for clinicians: Table 1
Rühl, A. (2006) · Gut · doi:10.1136/gut.2005.084426 · Cited by 24 · see citing works
Marine Toxins and Nociception: Potential Therapeutic Use in the Treatment of Visceral Pain Associated with Gastrointestinal Disorders
Baj, A., Bistoletti, M., Bosi, A., Moro, E., Giaroni, C., & Crema, F. (2019) · Toxins · doi:10.3390/toxins11080449 · Cited by 23 · see citing works
Self-citation
Plasticity of the enteric nervous system in patients with intestinal neuronal dysplasia associated with Hirschsprung?s disease: a report of three patients
Meyrat, B. J., & Laurini, R. (2003) · Pediatric Surgery International · doi:10.1007/s00383-003-1035-0 · Cited by 23 · see citing works
Toxoplasma gondiicauses death and plastic alteration in the jejunal myenteric plexus
Araújo, E. J. D. A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i16.4829 · Cited by 23 · see citing works
Development of the enteric nervous system
Bates, M. D. (2002) · Clinics in Perinatology · doi:10.1016/s0095-5108(03)00066-6 · Cited by 23 · see citing works
Unsolved problems in the management of patients with gastro-oesophageal reflux disease
Stanghellini, V., Cogliandro, R. F., Cogliandro, L., GIORGIO, R. D., Barbara, G., & Corinaldesi, R. (2003) · Digestive and Liver Disease · doi:10.1016/j.dld.2003.09.003 · Cited by 23 · see citing works
Concise Review: Cellular and Molecular Mechanisms of Postnatal Injury-Induced Enteric Neurogenesis
Jonscher, R. L., & Belkind‐Gerson, J. (2019) · Stem Cells · doi:10.1002/stem.3045 · Cited by 22 · see citing works
Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon
Makowska, K., & Gonkowski, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051024 · Cited by 21 · see citing works
Hyaluronan: A Neuroimmune Modulator in the Microbiota-Gut Axis
Bosi, A., Banfi, D., Bistoletti, M., Moretto, P., Moro, E., Crema, F., Maggi, F., Karousou, E. G., Viola, M., Passi, A. G., et al. (2021) · Cells · doi:10.3390/cells11010126 · Cited by 20 · see citing works
Self-citation
The pathogenesis of Hirschsprung disease
Belknap, W. M. (2002) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200201000-00013 · Cited by 20 · see citing works
Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation
Facer, P., Knowles, C. H., Thomas, P. K., Tam, P. K. H., Williams, N. S., & Anand, P. (2001) · British journal of surgery · doi:10.1046/j.1365-2168.2001.01731.x · Cited by 19 · see citing works
Integrated analysis of fish intestine biomarkers: Complementary tools for pollution assessment
Marinsek, G. P., Gusso‐Choueri, P. K., Choueri, R. B., Abessa, D. M. D. S., Gonçalves, A. R. N., Bortolotto, L. B., & Mari, R. D. B. (2022) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2022.113590 · Cited by 18 · see citing works
Enteric nervous system analyses: New biomarkers for environmental quality assessment
Marinsek, G. P., Abessa, D. M. D. S., Gusso‐Choueri, P. K., Choueri, R. B., Gonçalves, A. R. N., Barroso, B. V. D., Santos, G. S., Cestari, M. M., de Campos, B. G., & Mari, R. D. B. (2018) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2018.11.015 · Cited by 18 · see citing works
Age‐associated plasticity in the intrinsic innervation of the ovine rumen
Pfannkuche, H., Schellhorn, C., Schemann, M., Aschenbach, J. R., & Gäbel, G. (2003) · Journal of Anatomy · doi:10.1046/j.1469-7580.2003.00218.x · Cited by 17 · see citing works
Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis
Alam, K., Nair, L. S., Mukherjee, S., Kaur, K., Singh, M., Kaity, S., Ravichandiran, V., Banerjee, S., & Roy, S. (2024) · Bio-Design and Manufacturing · doi:10.1007/s42242-024-00282-6 · Cited by 16 · see citing works
Age‐related differences of γ‐aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle
Zizzo, M. G., Cicio, A., Raimondo, S., Alessandro, R., & Serio, R. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14248 · Cited by 15 · see citing works
Persistent Herpes Simplex Virus Type 1 Infection of Enteric Neurons Triggers CD8+ T Cell Response and Gastrointestinal Neuromuscular Dysfunction
Brun, P., Conti, J., Zatta, V., Russo, V., Scarpa, M., Kotsafti, A., Porzionato, A., De, R., Scarpa, M., Fassan, M., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.615350 · Cited by 14 · see citing works
Changes in nitrergic innervation of defunctionalized rat colon after diversion colostomy
Chaudhury, A., Shariff, A., Srinivas, M., & Sabherwal, U. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00565.x · Cited by 14 · see citing works
Involvement of glutamate receptors of the NMDA type in the modulation of acetylcholine and glutamate overflow from the guinea pig ileum during in vitro hypoxia and hypoglycaemia
Giuliani, D., Giaroni, C., Zanetti, E., Canciani, L., Borroni, P., Lecchini, S., & Frigo, G. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.10.005 · Cited by 14 · see citing works
Self-citation
Nitrergic Hyperinnervation in Appendicitis and in Appendices Histologically Classified as Normal
Németh, L., Rolle, U., Reen, D. J., & Puri, P. (2003) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2003-127-0573-nhiaai · Cited by 14 · see citing works
Focal, but not global, cerebral ischaemia causes loss of myenteric neurons and upregulation of vasoactive intestinal peptide in mouse ileum
Cheng, X., Svensson, M., Yang, Y., Deierborg, T., Ekblad, E., & Voss, U. (2018) · International Journal of Experimental Pathology · doi:10.1111/iep.12263 · Cited by 13 · see citing works
New Horizons in the Pathogenesis of Gastrointestinal Neuromuscular Disease
Knowles, C. H. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31812e6569 · Cited by 12 · see citing works
Adaptative responses of myenteric neurons of Sphoeroides testudineus to environmental pollution
Gonçalves, A. R. N., Marinsek, G. P., Abessa, D. M. D. S., & Mari, R. D. B. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.10.008 · Cited by 11 · see citing works
Involvement of Ca2+-dependent PKCs in the adaptive changes of μ-opioid pathways to sympathetic denervation in the guinea pig colon
Giaroni, C., Zanetti, E., Pascale, A., Oldrini, R., Canciani, L., Giuliani, D., Amadio, M., Chiaravalli, A. M., Lecchini, S., & Frigo, G. M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.107 · Cited by 11 · see citing works
Self-citation
Age-related changes in the myenteric plexus of the porcine bowel
Paran, T. S., Rolle, U., & Puri, P. (2009) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2008.12.018 · Cited by 10 · see citing works
Gut region-dependent alterations of nitrergic myenteric neurons after chronic alcohol consumption
Bagyánszki, M., & Bódi, N. (2015) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v6.i3.51 · Cited by 9 · see citing works
Perinatal and post-weaning exposure to a high-fat diet causes histomorphometric, neuroplastic, and histopathological changes in the rat ileum
Cordeiro, G. S., Góis, M. B., dos Santos, L. S., Santo, D. A. E., Silva, R. T., Pereira, M. U., dos Santos, J. N., da Conceição‐Machado, M. E. P., Deiró, T. C. B. J., & Medeiros, J. M. B. (2022) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174422000514 · Cited by 9 · see citing works
Persons Versus Brains: Biological Intelligence in Human Organisms
Steinhart, E. C. (2001) · Biology & Philosophy · doi:10.1023/a:1006718411266 · Cited by 9 · see citing works
Oligophrenin‐1, a Rho GTPase‐activating protein (RhoGAP) involved in X‐linked mental retardation, is expressed in the enteric nervous system
Xiao, J., Neylon, C. B., Hunne, B., & Furness, J. B. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10072 · Cited by 9 · see citing works
Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction
Jamka, J. R., & Gulbransen, B. D. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14870 · Cited by 8 · see citing works
Functional interaction between α2-adrenoceptors, μ- and κ-opioid receptors in the guinea pig myenteric plexus: Effect of chronic desipramine treatment
Canciani, L., Giaroni, C., Zanetti, E., Giuliani, D., Pisani, R., Moro, E., Trinchera, M., Crema, F., Lecchini, S., & Frigo, G. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.025 · Cited by 8 · see citing works
Self-citation
Changes Caused by Bisphenols in the Chemical Coding of Neurons of the Enteric Nervous System of Mouse Stomach
Makowska, K., & Gonkowski, S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20065125 · Cited by 7 · see citing works
Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon
Giaroni, C., Zanetti, E., Vanti, A., Canciani, L., Lecchini, S., & Frigo, G. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01961-6 · Cited by 7 · see citing works
Self-citation
The role of the cytoskeleton in capacitaftive calcium entry in myenteric glia
Lin, T. R.-Y., Zhang, W., Garrido, R., Segura, B. J., Hu, Y., Guzman, E. A., & Mulholland, M. T. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00406.x · Cited by 7 · see citing works
Chapter 9 Innervation of the small intestine
Ekblad, E., & Sundler, F. (2002) · Biology of growing animals · doi:10.1016/s1877-1823(09)70125-0 · Cited by 8 · see citing works
Age-associated changes of the intrinsic nervous system in relation with interstitial cells in the pre-weaning goat rumen
Liang, Y., Tarique, I., Vistro, W. A., Liu, Y., Wang, Z., Haseeb, A., Gandahi, N. S., Iqbal, A., Wang, S., An, T., et al. (2019) · Aging · doi:10.18632/aging.102076 · Cited by 6 · see citing works
Oral Delivery of Pathogens from the Intestine to the Nervous System
Baird, A. W., Campion, D. P., O’Brien, L., & Brayden, D. J. (2004) · Journal of drug targeting · doi:10.1080/10611860410001693715 · Cited by 6 · see citing works
Actions of Probiotics on Trinitrobenzenesulfonic Acid-Induced Colitis in Rats
Shiina, T., Shima, T., Naitou, K., Nakamori, H., Sano, Y., Horii, K., Shimakawa, M., Ohno, H., & Shimizu, Y. (2015) · BioMed Research International · doi:10.1155/2015/528523 · Cited by 5 · see citing works
Drugs acting on the gastrointestinal system
Murray, M. J. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7020-2484-9.50010-9 · Cited by 4 · see citing works
Plasticity of rat small intestine after removal of a chronic mechanical obstruction
Bertoni, S., Gabella, G., Ballabeni, V., Ghirardi, A., Impicciatore, M., & Barocelli, E. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00818.x · Cited by 4 · see citing works
Neurochemical Remodelling of the Enteric Nervous System Neurons in the Porcine Jejunum Following Low-Dose Glyphosate Exposure
Palus, K., Karpiesiuk, A., & Jana, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209840 · Cited by 3 · see citing works
Histological and neuronal changes in the duodenum of hamsters infected with Leishmania (Leishmania) infantum
Cavallone, I. N., de Lima, S. K. S., de Oliveira, K. S., Passero, L. F. D., Laurenti, M. D., Jesus, J. A., Marinsek, G. P., Chucri, T. M., & Mari, R. D. B. (2022) · Experimental Parasitology · doi:10.1016/j.exppara.2022.108315 · Cited by 3 · see citing works
Mesenteric Neural Stem Cell for Chronic Spinal Cord Injury: A Literature Review
Mahadewa, T. G. B., Mardhika, P. E., Awyono, S., Putra, M. B., Saapang, G. S., Wiyanjana, K. D. F., Putra, K. K., Natakusuma, T. I. S. D., & Ryalino, C. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6653 · Cited by 3 · see citing works
Nogo A expression in the adult enteric nervous system
Osborne, S. L., Corcoran, S. L., Prinjha, R. K., & Moore, S. E. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00527.x · Cited by 2 · see citing works
Involvement of protein kinase C in the adaptive changes of cholinergic neurons to sympathetic denervation in the guinea pig myenteric plexus
Zanetti, E., Giaroni, C., Vanti, A., Canciani, L., Giuliani, D., Lecchini, S., & Frigo, G. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00665-9 · Cited by 2 · see citing works
Self-citation
Effect of Surgical Alteration of the Rat Gastrointestinal Tract On the Growth and Development ofHymenolepis Diminuta
Dwinell, K. L., Bass, P., Telford, G. L., & Oaks, J. A. (2001) · Journal of Parasitology · doi:10.1645/0022-3395(2001)087[0721:eosaot]2.0.co;2 · Cited by 2 · see citing works
PARADOXICAL EFFECTS OF IMMUNE CELLS ON THE ENTERIC NERVOUS SYSTEM IN INTESTINAL INFLAMMATION
Venkataramana, S. (2009)
Molekulare Mechanismen des intestinalen Wasser- und Elektrolyttransportes und der Barrierefunktion
Seidler, U. E., & Bachmann, O. P. (2006) · Springer eBooks · doi:10.1007/3-540-37211-3_2

Neuroplasticity of the Enteric Nervous System Induced by Inflammatory Conditions of the Gut
GIORGIO, R. D., Vasina, V. I., Ursino, M., Barbara, G., Stanghellini, V., Ponti, F. D., & Corinaldesi, R. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000256187.41687.e1
Enteric glia: Diversity or plasticity?
Valès, S., Touvron, M. S., & Landeghem, L. V. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.001 · Cited by 29 · see citing works
Enteric nervous plasticity and development: dependence on neurotrophic factors
von Boyen, G. B. T., Reinshagen, M., Steinkamp, M., Adler, G., & Kirsch, J. (2002) · Journal of Gastroenterology · doi:10.1007/s005350200093 · Cited by 43 · see citing works
2004): Role of vasoactive intestinal peptide and inflammatory mediators in enteric neuronal plasticity. Neurogastroenterology and Motility
Ekblad, E., & Bauer, A. J. (2015)
Enteric neuroplasticity evoked by inflammation
Vasina, V., Barbara, G., Talamonti, L., Stanghellini, V., Corinaldesi, R., Tonini, M., De Ponti, F., & De Giorgio, R. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.025 · Cited by 221 · see citing works

Authors: Giaroni, C., De Ponti, F., Cosentino, M., Lecchini, S., & Frigo, G.
Affiliations: University of Pavia (IT)
University of Insubria (IT)
ORCID: Giaroni, Cristina
Cosentino, Marco
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1999-12
Volume: 117
Issue: 6
Pages: 1438-1458
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/s0016-5085(99)70295-7
OpenAlex: W2125227017
Cited by: 119
References: 226
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 1 · 2013: 4 · 2012: 1
FWCI: 1.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
IrInSubria (University of Insubria) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords: enteric nervous system, neuroplasticity, enteric ganglia, peristaltic reflex, neuronal connectivity, synaptic plasticity, enteric neurons, enteric disease
MeSH terms: Adaptation, Biological, Aging, Digestive System Physiological Phenomena, Environment, Humans, Neuronal Plasticity, Enteric Nervous System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasticity in the enteric nervous system

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks