Aromatization: Important for sexual differentiation of the neonatal rat brain
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Masculinization, initially attributed entirely to androgens, actually occurs through many estrogen-dependent mechanisms.
“Early in the study of steroid-induced sexual differentiation, it was discovered that masculinization—initially attributed entirely to the effects of androgens—actually occurred through many estrogen-dependent mechanisms.”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as McEwen et al., 1977
Neurons in some regions of the brain express high levels of aromatase, which converts testosterone into estradiol.
“Neurons in some regions of the brain express high levels of the enzyme aromatase, which converts testosterone into estradiol (Naftolin et al., 1975; McEwen et al., 1977).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as McEwen et al., 1977
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Self-citationDistribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain
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- Authors
- McEwen, B. S., Lieberburg, I., Chaptal, C., & Krey, L. C.
- Affiliations
- Rockefeller University (US)
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 1977-12
- Volume
- 9
- Issue
- 3
- Pages
- 249-263
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2091926828
- Cited by
- 443
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 4 · 2012: 11
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Rockefeller Foundation
- U.S. Public Health Service
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- aromatization, sexual differentiation of the brain, neonatal brain, testosterone, estradiol, antiestrogens, aromatase inhibition, lordosis behavior, ovarian function, luteinizing hormone surge, vaginal opening
- MeSH terms
- Androstatrienes, Animals, Brain, Estradiol, Estrogen Antagonists, Female, Luteinizing Hormone, Male, Nitromifene, Ovary, Oxidoreductases, Posture, Progesterone, Sexual Behavior, Animal, Sex Differentiation, Testosterone, Vagina, Aromatase Inhibitors, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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