Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain

Pérez, Sylvia E; Chen, E.-Y; Mufson, Elliott J

doi:10.1016/s0165-3806(03)00223-2

Cited by 228Estrogen and related hormone effectsSexual Differentiation and DisordersHypothalamic control of reproductive hormones

Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain

Pérez, Sylvia E, Chen, E.-Y, Mufson, Elliott J·2003·Developmental Brain Research

DOI 10.1016/s0165-3806(03)00223-2

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Abstract

The present study was conducted to identify the localization and possible contribution of the two estrogen receptor (ER) subtypes in the rat brain at postnatal (P) days 3, 7 and 14. Evaluation of the distribution of ERalpha and ERbeta immunoreactive (ir) nuclei did not reveal gender differences at the developmental point times examined. With the exception of the cerebral cortex, the pattern of staining for these ERs was unchanged across the postnatal ages examined. The distribution of ERalpha-ir nuclei was wider than ERbeta-ir during brain development. From P3, ERbeta and ERalpha-ir nuclei were found in different regions of the cerebral cortex, basal forebrain, amygdala, thalamus, hypothalamus, mesencephalon, pons, cerebellum and medulla oblongata. In addition, ERalpha-ir nuclei were exclusively detected in the hippocampal subfields, epithalamus and in several circumventricular organs. ERalpha and ERbeta dual immunofluorescence revealed positive nuclei in the medial part of the bed nucleus of the stria terminalis, periventricular preoptic nucleus and in caudal aspects of the ventrolateral part of the ventromedial hypothalamic nucleus. Although the functional significance of the dual expression of both ERs within the same nuclei remains unknown, it is possible that ERs play different roles in gene regulation within the same cell. The presence of ERs in diverse brain regions through early postnatal periods supports a potential role for estrogens in neural differentiation.

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In neonatal rodents, ERalpha is expressed relatively abundantly in neocortex while ERbeta is mostly absent.
“In neonatal rodents, ERalpha is expressed relatively abundantly in neocortex while ERbeta is mostly absent (Perez et al., 2003; Zsarnovszky and Belcher, 2001).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Perez et al., 2003
Estrogen receptors in frontal cortex are specifically localized to PV+ interneurons: ERbeta, the predominant nuclear estrogen receptor expressed in cortex during puberty and adulthood, is expressed almost exclusively in PV+ interneurons.
“Estrogen receptors in frontal cortex are specifically localized to PV+ interneurons: ERbeta, the predominant nuclear estrogen receptor expressed in cortex during puberty and adulthood (Kritzer, 2002; Pérez et al., 2003; Shughrue et al., 1998), is expressed almost exclusively in PV+ interneurons.”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Pérez et al., 2003

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Estradiol Improves Cerebellar Memory Formation by Activating Estrogen Receptor β
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Distribution and Estrogen Regulation of Membrane Progesterone Receptor-β in the Female Rat Brain
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ERβ in CNS: New Roles in Development and Function
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Sex-specific <i>Esr2</i> mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure
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Estrogen in the Limbic System
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Changes in peak expiratory flow and respiratory strength during the menstrual cycle
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Nuclear and Extranuclear Estrogen Binding Sites in the Rat Forebrain and Autonomic Medullary Areas
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Estrogen Modulates Endothelial and Neuronal Nitric Oxide Synthase Expression via an Estrogen Receptor β-Dependent Mechanism in Hypothalamic Slice Cultures
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Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR‐218/ PTPA pathway
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Increasing Hippocampal Estrogen Receptor Alpha Levels via Viral Vectors Increases MAP Kinase Activation and Enhances Memory in Aging Rats in the Absence of Ovarian Estrogens
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Sex and gonadal steroid modulation of pheromone receptor gene expression in the mouse vomeronasal organ
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Androgens Enhance Adult Hippocampal Neurogenesis in Males but Not Females in an Age-Dependent Manner
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Oestrogen Signalling and Neuroprotection in Cerebral Ischaemia
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Sex-specific densities of estrogen receptors alpha and beta in the subnuclei of the nucleus tractus solitarius, hypoglossal nucleus and dorsal vagal motor nucleus weanling rats
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Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice
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Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain
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Heterogeneous expression of hydrocephalic phenotype in the hyh mice carrying a point mutation in α-SNAP
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Authors: Pérez, S. E., Chen, E.-Y., & Mufson, E. J.
Affiliations: Rush University Medical Center (US)
Corresponding author: Mufson, Elliott J
ORCID: Mufson, Elliott J
Venue: Developmental Brain Research
Publisher: Elsevier BV
Published: 2003-10
Volume: 145
Issue: 1
Pages: 117-139
ISSN: 0165-3806 (ISSN-L)
DOI: 10.1016/s0165-3806(03)00223-2
OpenAlex: W1987321973
Cited by: 228
References: 89
Citations by year: 2026: 1 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 5 · 2012: 9
FWCI: 6.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Developmental Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-16765, AG-14449, P01AG014449, P01AG016765, AG10688)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: estrogen receptor alpha, estrogen receptor beta, postnatal brain development, hippocampus, circumventricular organs, bed nucleus of the stria terminalis, ventromedial hypothalamus, cerebral cortex, rat brain
MeSH terms: Aging, Animals, Animals, Newborn, Brain, Female, Immunohistochemistry, Male, Neurons, Rats, Inbred F344, Receptors, Estrogen, Estrogen Receptor alpha, Estrogen Receptor beta, Rats

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Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain

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