Effects of eicosapentaenoic acid on plasma lipoprotein subfractions and activities of lecithin: cholesterol acyltransferase and lipid transfer protein
Abstract
The effects of 12 weeks eicosapentaenoic acid (EPA) administration (2.7 g/day) on plasma lipoprotein subfraction levels and on activities of lecithin: cholesterol acyltransferase (LCAT) and lipid transfer protein (LTP) were investigated. Plasma VLDL-C, VLDL-TG, VLDL-PL, VLDL-apo B, VLDL-apo C-II and VLDL-apo C-III levels were decreased by 32.8% (P less than 0.05), 31.2% (P less than 0.01), 31.5% (P less than 0.05), 32.5% (P less than 0.05), 34.7% (P less than 0.05) and 34.1% (P less than 0.05), respectively. EPA did not change plasma IDL-TC, IDL-TG, IDL-PL and IDL-apo B levels. Plasma large, light LDL (LDL1)-TC, LDL1-PL and LDL1-apo B levels were decreased by EPA by 18.7% (P less than 0.02), 19.1% (P less than 0.01) and 23.3% (P less than 0.01) while LDL1-TG level was not changed. Plasma small, heavy LDL (LDL2)-TC level was increased by 25.7% (P less than 0.02) while LDL2-TG, LDL2-PL and LDL2-apo B levels were not altered. Plasma HDL2-TC, HDL2-TG, HDL2-PL and HDL2-apo A-I levels stayed unchanged by EPA treatment. EPA did not affect plasma HDL3-TC, HDL3-PL and HDL3-apo A-I levels but decreased HDL3-TG level significantly (P less than 0.02). LCAT activity was not altered by EPA. LTP activity was increased by 24.8% at 4 weeks (P less than 0.02) and by 32.1% (P less than 0.001) at 12 weeks EPA treatment. We conclude that EPA reduces plasma large, light LDL levels as well as plasma VLDL amounts and stimulates LTP activities.
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A consistent finding is an increase in mean LDL particle size, with a resulting shift towards those classified as large, rather than small, LDL particles.
“A consistent finding is an increase in mean LDL particle size, with a resulting shift towards those classified as large, rather than small, LDL particles [7, 45, 51–54].”
EPA alone does not change total plasma levels of apoCIII or apoCII, but decreases apoCII and apoCIII in VLDL.
“EPA alone does not change total plasma levels of apoCIII or apoCII, but decreases apoCII and apoCIII in VLDL [45].”
Inconsistent effects on CETP activity have been observed following treatment with OM3FAs: either no change, an increase or a decrease in activity.
“Inconsistent effects on CETP activity have been observed following treatment with OM3FAs: either no change [56], an increase [45] or a decrease [57] in activity.”
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Self-citation
- Authors
- Homma, Y., Ohshima, K., Yamaguchi, H., Nakamura, H., Araki, G., & Goto, Y.
- Affiliations
- Tokai University (JP)
- Corresponding author
- Homma, Yasuhiko
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 91
- Issue
- 1-2
- Pages
- 145-153
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2023891775
- Cited by
- 29
- References
- 36
- Citations by year
- 2018: 1 · 2017: 1 · 2016: 3 · 2014: 3 · 2013: 1
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- eicosapentaenoic acid, omega-3 fatty acids, lecithin:cholesterol acyltransferase, lipid transfer proteins, VLDL, LDL subclasses, HDL cholesterol, apolipoproteins, triglycerides, phospholipids, cholesterol, lipoprotein metabolism, fish oil supplementation, dyslipidemia
- MeSH terms
- Adult, Aged, Apoproteins, Carrier Proteins, Electrophoresis, Polyacrylamide Gel, Female, Humans, Phosphatidylcholine-Sterol O-Acyltransferase, Lipids, Lipoproteins, Male, Middle Aged, Eicosapentaenoic Acid
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