Cited by 172Bacteriophages and microbial interactionsBacterial Genetics and BiotechnologyCRISPR and Genetic Engineering

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Bacteriophage P1 cre gene and its regulatory region

Sternberg, N., Sauer, B., Hoess, R., Abremski, K.·1986·Journal of Molecular Biology

Open this paper in CoChat — free account

Abstract

The bacteriophage P1 site-specific recombination system consists of two components, a site, loxP, at which recombination occurs, and a recombinase protein, Cre. In this paper, we present the DNA sequence of the cre structural gene and its upstream regulatory region. Analysis of the sequence indicates: (1) that cre encodes a protein of 343 amino acids; (2) that cre and loxP are separated by a 434 base-pair region that contains a 73 amino acid open reading frame, orf1; and (3) that cre and orf1 are oriented with their amino-terminal ends proximal to loxP. We have identified three promoters that are located upstream of the cre structural gene. Their activities range from 7 to 10% of the activity of the galactose operon promoter. The promoter furthest from cre, pR1, contains two Dam methylation sites (5'-G-A-T-C-3') in its -35 region, and is sensitive to Dam methylation. Its transcription is three- to fourfold higher in a dam- host than it is in a dam+ host. The promoter closest to cre, pR3, signals the production of an RNA transcript that functions inefficiently for Cre protein synthesis because it lacks a ribosome recognition site. None of the three cre promoters is sensitive to proteins expressed by the P1 prophage, including the c1 repressor protein. To assess the role of cre in the P1 life-cycle, we isolated cre mutants and studied their behavior in recA+ and recA- hosts. Those studies indicate that Cre is dispensable for viral vegetative growth and lysogeny in a recA+ host,…

Integrity signals

Registry

Crossref · 10.1016/0022-2836(86)90228-7

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Experiments in molecular genetics
Miller, J. H. (1972) · Medical Entomology and Zoology · Cited by 27,157
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers
Vieira, J., & Messing, J. W. (1982) · Gene · doi:10.1016/0378-1119(82)90015-4 · Cited by 5,984
A rapid boiling method for the preparation of bacterial plasmids
Holmes, D. S., & Quigley, M. E. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90473-5 · Cited by 3,198
A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase
Sanger, F., & Coulson, A. R. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90213-2 · Cited by 2,709
REGULATORY SEQUENCES INVOLVED IN THE PROMOTION AND TERMINATION OF RNA TRANSCRIPTION
Rosenberg, M. J., & Court, D. L. (1979) · Annual Review of Genetics · doi:10.1146/annurev.ge.13.120179.001535 · Cited by 2,703
Compilation and analysis ofEscherichia colipromoter DNA sequences
Hawley, D. K., & McClure, W. R. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.8.2237 · Cited by 2,217
Prolonged incubation in calcium chloride improves the competence of Escherichia coli cells
Dagert, M., & Ehrlich, S. D. (1979) · Gene · doi:10.1016/0378-1119(79)90082-9 · Cited by 1,417
SEGREGATION OF NEW LYSOGENIC TYPES DURING GROWTH OF A DOUBLY LYSOGENIC STRAIN DERIVED FROM ESCHERICHIA COLI K12
Appleyard, R. K. (1954) · Genetics · doi:10.1093/genetics/39.4.440 · Cited by 961
Bacteriophage P1 site-specific recombination
Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 813
Self-citation
Characterization of translational initiation sites inE. coli
Stormo, G. D., Schneider, T. D., & Gold, L. M. (1982) · Nucleic Acids Research · doi:10.1093/nar/10.9.2971 · Cited by 671

Show all 36 references

Research works printed but not linked: 9

Clewell, 1969, 62, 1159
Gottesman, 1968, 33, 735
Hoess, 1982, 79, 3398
Kleckner, 1984, 49, 235
Lin, 1984, Mol. Cell. Biol., 4, 1020, 10.1128/MCB.4.6.1020 · DOI
Marinus, 1985, Mol. Gen. Genet.
McKenney, 1981, vol. 2, 384
Shine, 1974, 71, 1342
Sternberg, 1981, 45, 297

Sorted by citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Antibody-selectable filamentous fd phage vectors: affinity purification of target genes
Parmley, S. F., & Smith, G. P. (1988) · Gene · doi:10.1016/0378-1119(88)90495-7 · Cited by 871
Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.
Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., & Saito, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1320 · Cited by 788
Inducible Gene Targeting in Mice Using the Cre/loxSystem
Sauer, B. (1998) · Methods · doi:10.1006/meth.1998.0593 · Cited by 788
Self-citation
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ERT and Cre-ERT2 recombinases
Indra, A. K., Warot, X. M., Brocard, J., Bornert, J., Xiao, J. H., Chambon, P., & METZGER, D. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.22.4324 · Cited by 758
Epigenetic Gene Regulation in the Bacterial World
Casadesús, J., & Low, D. A. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-06 · Cited by 653
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
Kanegae, Y., Lee, G., Sato, Y., Tanaka, M., Nakal, M., Sakaki, T., Sugano, S., & Saito, I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.19.3816 · Cited by 606
Early-Onset Epilepsy and Postnatal Lethality Associated with an Editing-Deficient GluR-B Allele in Mice
Brusa, R., Zimmermann, F., Koh, D., Feldmeyer, D., Gass, P., Seeburg, P. H., & Sprengel, R. (1995) · Science · doi:10.1126/science.270.5242.1677 · Cited by 594
Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.
Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570
N6-methyl-adenine: an epigenetic signal for DNA–protein interactions
Wion, D., & Casadesús, J. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1350 · Cited by 527
Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae
Sauer, B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.6.2087 · Cited by 482
Self-citation
Similarities and differences among 105 members of the Int family of site-specific recombinases
Nunes-Düby, S. E., Kwon, H. J., Tirumalai, R. S., Ellenberger, T., & Landy, A. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.2.391 · Cited by 448
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.
Elledge, S. J., Mulligan, J. T., Ramer, S. W., Spottswood, M. R., & Davis, R. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1731 · Cited by 345
Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
Kim, H., Kim, M., Im, S., & Fang, S. (2018) · Laboratory Animal Research · doi:10.5625/lar.2018.34.4.147 · Cited by 416
Genome of Bacteriophage P1
Łobocka, M. B., Rose, D. J., Plunkett, G., Rusin, M., Samojedny, A., Lehnherr, H., Yarmolinsky, M. B., & Blattner, F. R. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.21.7032-7068.2004 · Cited by 308
Bacteriophage P1 cloning system for the isolation, amplification, and recovery of DNA fragments as large as 100 kilobase pairs.
Sternberg, N. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.103 · Cited by 264
Self-citation
Bacteriophage Orphan DNA Methyltransferases: Insights from Their Bacterial Origin, Function, and Occurrence
Murphy, J., Mahony, J., Ainsworth, S., Nauta, A., & van Sinderen, D. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.02229-13 · Cited by 258
[2] Bacteriophage-mediated generalized transduction in Escherichia coli and Salmonella typhimurium
Sternberg, N. L., & Maurer, R. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)04004-8 · Cited by 236
Self-citation
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
Andrechek, E. R., Hardy, W. R., Siegel, P. M., Rudnicki, M. A., Cardiff, R. D., & Muller, W. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3444 · Cited by 230
Suicide recombination substrates yield covalent lambda integrase-DNA complexes and lead to identification of the active site tyrosine.
Pargellis, C. A., Nunes-Düby, S. E., de Vargas, L. M., & Landy, A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68552-7 · Cited by 190
Cre/ loxP Recombination System and Gene Targeting
Kühn, R., & Torres, R. M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-178-7:175 · Cited by 184
Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression
Anton, M., & Graham, F. L. (1995) · Journal of Virology · doi:10.1128/jvi.69.8.4600-4606.1995 · Cited by 184
Transgene Coplacement and High Efficiency Site-Specific Recombination With the Cre/loxP System in Drosophila
Siegal, M. L., & Hartl, D. L. (1996) · Genetics · doi:10.1093/genetics/144.2.715 · Cited by 169
Use of the Cre/lox Recombination System to Develop a Non-lethal Knock-in Murine Model for Osteogenesis Imperfecta with an α1(I) G349C Substitution
Forlino, A., Porter, F. D., Lee, E. J., Westphal, H., & Marini, J. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37923 · Cited by 159
A positive selection vector for cloning high molecular weight DNA by the bacteriophage P1 system: improved cloning efficacy.
Pierce, J. C., Sauer, B., & Sternberg, N. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2056 · Cited by 158
Self-citation
DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages
Sauer, B. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh941 · Cited by 155
Self-citation
An araC-controlled Bacterialcre Expression System to Produce DNA Minicircle Vectors for Nuclear and Mitochondrial Gene Therapy
Bigger, B., Tolmachov, O. E., Collombet, J.-M., Fragkos, M., Palaszewski, I., & Coutelle, C. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010873200 · Cited by 149
Molecular characterization of two proteins involved in the excision of the conjugative transposon Tn1545: homologies with other site‐specific recombinases.
Poyart, C., Trieu‐Cuot, P., Carlier, C., & Courvalin, P. M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08373.x · Cited by 144
Engineered tRNAs suppress nonsense mutations in cells and in vivo
Albers, S., Allen, E. C., Bharti, N., Davyt, M., Joshi, D., Pérez‐García, C. G., Santos, L. A., Mukthavaram, R., Delgado-Toscano, M. A., Molina, B., et al. (2023) · Nature · doi:10.1038/s41586-023-06133-1 · Cited by 140
Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA
Iyer, L. M., Zhang, D., Burroughs, A. M., & Aravind, L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt573 · Cited by 137
Role of the Carboxy-Terminal Region of the GluRε2 Subunit in Synaptic Localization of the NMDA Receptor Channel
Mori, H., Manabe, T., Watanabe, M., Satoh, Y., Suzuki, N., Toki, S., Nakamura, K., Yagi, T., Kushiya, E., Takahashi, T., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80567-x · Cited by 136
Bacteriophage P1
Yarmolinsky, M. B., & Sternberg, N. L. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5424-6_9 · Cited by 131
Self-citation
DNA Methylation
Marinus, M., & Løbner‐Olesen, A. (2014) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0003-2013 · Cited by 125
Silencing of Phosphoethanolamine N-Methyltransferase Results in Temperature-Sensitive Male Sterility and Salt Hypersensitivity in Arabidopsis
Mou, Z., Wang, X., Fu, Z., Dai, Y., Han, C. D., Ouyang, J., Bao, F., Hu, Y., & Li, J. (2002) · The Plant Cell · doi:10.1105/tpc.001701 · Cited by 125
Methylation of DNA in Prokaryotes
Noyer-Weidner, M., & Trautner, T. A. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9118-9_4 · Cited by 124
Enhanced efficiency through nuclear localization signal fusion on phage phiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells
Andreas, S. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2299 · Cited by 124
An array of target-specific screening strains for antibacterial discovery
DeVito, J. A., Mills, J. A., Liu, V. G., Agarwal, A., Sizemore, C. F., Yao, Z., Stoughton, D., Cappiello, M. G., Barbosa, M. D. F. S., Foster, L. A., et al. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-478 · Cited by 114
Gene knock-out technology: a methodological overview for the interested novice
Galli-Taliadoros, L. A., Sedgwick, J. D., Wood, S. A., & Körner, H. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00017-5 · Cited by 112
The integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens is related to temperate bacteriophages.
Boccard, F., Smokvina, T., Pernodet, J., Friedmann, A., & Guérineau, M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03460.x · Cited by 109
Integration of satellite bacteriophage P4 in Escherichia coli
Pierson, L. S., & Kahn, M. L. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90026-x · Cited by 108
A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor
Brocard, J. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.17.4086 · Cited by 104
Cre recombinase expression can result in phenotypic aberrations in plants
Coppoolse, E. R., de Vroomen, M. J., Roelofs, D., Smit, J. J. M., van Gennip, F., Hersmus, B. J. M., Nijkamp, H. J. J., & van Haaren, M. J. J. (2003) · Plant Molecular Biology · doi:10.1023/a:1021174726070 · Cited by 93
DNA methylation as a mechanism of transcriptional regulation in nonphotosynthetic plastids in plant cells.
Ngernprasirtsiri, J., Kobayashi, H., & Akazawa, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4750 · Cited by 92
The DIRS1 Group of Retrotransposons
Goodwin, T. J. D., & Poulter, R. T. M. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003748 · Cited by 87
Bacterial DNA Methylation and Methylomes
Casadesús, J. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-43624-1_3 · Cited by 80
Molecular genetics of the chloramphenicol‐resistance transposon Tn4451 from Clostridium perfringens: the TnpX site‐specific recombinase excises a circular transposon molecule
Bannam, T. L., Crellin, P. K., & Rood, J. I. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02417.x · Cited by 77
A Candida albicans RAS-related gene (CaRSRl) is involved in budding, cell morphogenesis and hypha development
Yaar, L., Mevarech, M., & Koltint, Y. (1997) · Microbiology · doi:10.1099/00221287-143-9-3033 · Cited by 76
A mutational analysis of the bacteriophage P1 recombinase Cre
Wierzbicki, A., Kendall, M., Abremski, K., & Hoess, R. H. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90484-0 · Cited by 74
Self-citation
[47] Using bacteriophage P1 system to clone high molecular weight genomic DNA
Pierce, J. C., & Sternberg, N. L. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)16049-p · Cited by 74
Self-citation
Cleavage of the bacteriophage P1 packaging site (pac) is regulated by adenine methylation.
Sternberg, N. L., & Coulby, J. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.8070 · Cited by 72
Self-citation
Silencing Inhibits Cre-Mediated Recombination of the Z/AP and Z/EG Reporters in Adult Cells
Long, M. A., & Rossi, F. M. V. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005435 · Cited by 73
The Unconventional Xer Recombination Machinery of Streptococci/Lactococci
Bourgeois, P., Bugarel, M., Campo, N., Daveran‐Mingot, M., Labonté, J., Lanfranchi, D., Lautier, T., Pagès, C., & Ritzenthaler, P. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030117 · Cited by 69
Cre Mutants with Altered DNA Binding Properties
Hartung, M., & Kisters–Woike, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.22884 · Cited by 65
Lymphocyte Ontogeny and Activation in Gene Targeted Mutant Mice
Pfeffer, K., & Mak, T. W. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.002055 · Cited by 65
DNA specificity of the cre recombinase resides in the 25 kDa carboxyl domain of the protein
Hoess, R. H., Abremski, K., Irwin, S., Kendall, M., & Mack, A. (1990) · Journal of Molecular Biology · doi:10.1016/s0022-2836(99)80007-2 · Cited by 63
Self-citation
Recognition and cleavage of the bacteriophage P1 packaging site (pac)
Sternberg, N. L., & Coulby, J. N. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90675-9 · Cited by 61
Self-citation
Filamentous Fusion Phage Cloning Vectors for the Study of Epitopes and Design of Vaccines
Parmley, S. F., & Smith, G. P. (1989) · Springer eBooks · doi:10.1007/978-1-4757-2046-4_21 · Cited by 61
The cyclization of linear DNA in Escherichia coli by site-specific recombination
Sauer, B., & Henderson, N. (1988) · Gene · doi:10.1016/0378-1119(88)90205-3 · Cited by 61
Self-citation
Cre-lox recombination in Escherichia coli cells mechanistic differences from the in Vitro reaction
Adams, D. E., Bliska, J. B., & Cozzarelli, N. R. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90623-r · Cited by 60
Recognition and cleavage of the bacteriophage P1 packaging site (pac)
Sternberg, N. L., & Coulby, J. N. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90674-7 · Cited by 59
Self-citation
A Set ofloxPMarker Cassettes for Cre-mediated Multiple Gene Disruption inSchizosaccharomyces pombe
Iwaki, T., & Takegawa, K. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.545 · Cited by 56
Synthesis of FinP RNA by Plasmids F and pSLT Is Regulated by DNA Adenine Methylation
Torreblanca, J., Marqués, S., & Casadesús, J. (1999) · Genetics · doi:10.1093/genetics/152.1.31 · Cited by 56
Proinflammatory effect in whole blood by free soluble bacterial components released from planktonic and biofilm cells
Oscarsson, J., Karched, M., Thay, B., Chen, C., & Asikainen, S. E. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-206 · Cited by 54
The Cre-lox Recombination System
Hoess, R. H., & Abremski, K. (1990) · Nucleic acids and molecular biology · doi:10.1007/978-3-642-84150-7_6 · Cited by 55
Self-citation
Cre/lox: One More Step in the Taming of the Genome
Sauer, B. (2002) · Endocrine · doi:10.1385/endo:19:3:221 · Cited by 55
Self-citation
TGF-β superfamily signaling is essential for tooth and hair morphogenesis and differentiation
Klopcic, B. R. S., Maass, T., Meyer, E., Lehr, H. A., METZGER, D., Chambon, P., Mann, A., & Blessing, M. (2007) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2007.03.005 · Cited by 51
The Legacy of Nat Sternberg: The Genesis of Cre-lox Technology
Yarmolinsky, M. B., & Hoess, R. H. (2015) · Annual Review of Virology · doi:10.1146/annurev-virology-100114-054930 · Cited by 50
Self-citation
Genetic Analysis of the Mobilization and Leading Regions of the IncN plasmids pKM101 and pCU1
Paterson, E. S., Moré, M. I., Pillay, G., Cellini, C., Woodgate, R., Walker, G. C., Iyer, V. N., & Winans, S. C. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.8.2572-2583.1999 · Cited by 47
An Adenovirus–Epstein-Barr Virus Hybrid Vector That Stably Transforms Cultured Cells with High Efficiency
Tan, B. T., Wu, L., & Berk, A. J. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7582-7589.1999 · Cited by 46
Nucleotide sequence of the rci gene encoding shufflon-specific DNA recombinase in the IncI1 plasmid R64: Homology to the site-specific recombinases of intergrase family
Kubo, A., Kusukawa, A., & Komano, T. (1988) · Molecular and General Genetics MGG · doi:10.1007/bf00333394 · Cited by 46
Enhanced cell-permeant Cre protein for site-specific recombination in cultured cells
Lin, Q., Jo, D., Gebre-Amlak, K. D., & Ruley, H. E. (2004) · BMC Biotechnology · doi:10.1186/1472-6750-4-25 · Cited by 44
Generation of marker free salt tolerant transgenic plants of Arabidopsis thaliana using the gly I gene and cre gene under inducible promoters
Roy, S. D., Saxena, M., Bhomkar, P., Pooggin, M. M., Höhn, T., & Sarin, N. B. (2008) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-008-9402-0 · Cited by 41
Sequence-Independent Assembly of Spermatid mRNAs into Messenger Ribonucleoprotein Particles
Schmidt, E. E., Hanson, E. S., & Capecchi, M. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3904 · Cited by 41
Role of DNA Methyltransferases in Epigenetic Regulation in Bacteria
Kumar, R., & Rao, D. N. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4525-4_4 · Cited by 40
Transfer of single gene-containing long terminal repeats into the genome of mammalian cells by a retroviral vector carrying the cre gene and the loxP site
Choulika, A., Guyot, V., & Nicolas, J. F. (1996) · Journal of Virology · doi:10.1128/jvi.70.3.1792-1798.1996 · Cited by 39
Characterization of the binding sites of c1 repressor of bacteriophage P1
Eliason, J. L., & Sternberg, N. L. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90313-5 · Cited by 39
Self-citation
Generating Marker-Free Transgenic Wheat Using Minimal Gene Cassette and Cold-Inducible Cre/Lox System
Mészáros, K., Éva, C., Kiss, T., Bányai, J., Kiss, E., Téglás, F., Láng, L., Karsaï, I., & Tamás, L. (2014) · Plant Molecular Biology Reporter · doi:10.1007/s11105-014-0830-1 · Cited by 38
Sequence analysis of theNgoPII methyltransferase gene fromNeisseria gonorrhoeaeP9: homologies with other enzymes recognizing the sequence 5′-GGCC-3′
Sullivan, K. M., & Saunders, J. R. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.10.4369 · Cited by 38
Stimulation of IS1 excision by bacteriophage P1 ref function
Lu, S.-D., Lu, D., & Gottesman, M. E. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.6.3427-3432.1989 · Cited by 36
Functional Expression of the cre-lox Site-Specific Recombination System in the Yeast Saccharomyces cerevisiae
Sauer, B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.6.2087-2096.1987 · Cited by 36
Self-citation
Control of prophage integration and excision in bacteriophage P2: nucleotide sequences of the int gene and att sites
Yu, A., Bertani, L. E., & Haggård‐Ljungquist, E. (1989) · Gene · doi:10.1016/0378-1119(89)90244-8 · Cited by 36
Modification of the Genome of Rhodobacter sphaeroides and Construction of Synthetic Operons
Jaschke, P. R., Saer, R. G., Noll, S., & Beatty, J. T. (2011) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-385075-1.00023-8 · Cited by 34
Development of a P1 phagemid system for the delivery of DNA into Gram-negative bacteria
Westwater, C., Schofield, D. A., Schmidt, M. G., Norris, J. S., & Dolan, J. W. (2002) · Microbiology · doi:10.1099/00221287-148-4-943 · Cited by 34
Restoring pollen fertility in transgenic male-sterile eggplant by Cre/loxp-mediated site-specific recombination system
Cao, B., Huang, Z., Chen, G., & Lei, J. (2010) · Genetics and Molecular Biology · doi:10.1590/s1415-47572010005000043 · Cited by 34
Systematic and scalable genome-wide essentiality mapping to identify nonessential genes in phages
Piya, D., Nolan, N., Moore, M. L., Ramirez Hernandez, L. A., Cress, B. F., Young, R., Arkin, A. P., & Mutalik, V. K. (2023) · PLOS Biology · doi:10.1371/journal.pbio.3002416 · Cited by 31
Use of the Cre- lox Recombination System To Investigate the lp54 Gene Requirement in the Infectious Cycle of Borrelia burgdorferi
Bestor, A. C., Stewart, P. E., Jewett, M. W., Sarkar, A., Tilly, K., & Rosa, P. A. (2010) · Infection and Immunity · doi:10.1128/iai.01059-09 · Cited by 31
Accessory Genes in thedarAOperon of Bacteriophage P1 Affect Antirestriction Function, Generalized Transduction, Head Morphogenesis, and Host Cell Lysis
Iida, S., Hiestand-Nauer, R., Sandmeier, H., Lehnherr, H., & Arber, W. (1998) · Virology · doi:10.1006/viro.1998.9405 · Cited by 30
Random segment deletion based on IS31831 and Cre/loxP excision system in Corynebacterium glutamicum
Tsuge, Y., Suzuki, N., Inui, M., & Yukawa, H. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0788-5 · Cited by 29
Adherence of Aggregatibacter actinomycetemcomitans via serotype‐specific polysaccharide antigens in lipopolysaccharides
Fujise, O., Wang, Y., Chen, W., & Chen, C. (2008) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2007.00416.x · Cited by 28
Use of Site-Specific Recombination Systems in Plants
Odell, J. T., & Russell, S. H. (1994) · Springer eBooks · doi:10.1007/978-94-011-1094-5_11 · Cited by 28
HARO7 Encodes Chorismate Mutase of the Methylotrophic Yeast Hansenula polymorpha and Is Derepressed upon Methanol Utilization
Krappmann, S., Pries, R., Gellissen, G., Hiller, M., & Braus, G. H. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.15.4188-4197.2000 · Cited by 28
Engineering Embryonic Stem Cells with Recombinase Systems
Schnütgen, F., Stewart, A. F., von Melchner, H., & Anastassiadis, K. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)20007-7 · Cited by 27
Production of a reporter transgenic pig for monitoring Cre recombinase activity
Li, L., Pang, D., Wang, T., Li, Z., Chen, L., Zhang, M., Song, N., Nie, D., Chen, Z., Lai, L., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.146 · Cited by 27
The c1 repressor of bacteriophage P1. Isolation and characterization of the repressor protein.
Dreiseikelmann, B., Velleman, M., & Schuster, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57316-1 · Cited by 26
A novel intrinsically disordered outer membrane lipoprotein ofAggregatibacter actinomycetemcomitansbinds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8
Ahlstrand, T., Tuominen, H. K., Beklen, A., Torittu, A., Oscarsson, J., Sormunen, R. T., Pöllänen, M. T., Permi, P., & Ihalin, R. (2016) · Virulence · doi:10.1080/21505594.2016.1216294 · Cited by 25
Genetic analysis of the lytic replicon of bacteriophage P1
Sternberg, N. L., & Cohen, G. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90444-0 · Cited by 25
Self-citation
Inducible gene expression systems inLactococcus lactis
Djordjevic, G. M., & Klaenhammer, T. R. (1998) · Molecular Biotechnology · doi:10.1007/bf02760814 · Cited by 24
Vector Systems for Prenatal Gene Therapy: Principles of Non-viral Vector Design and Production
Wong, S. P., Argyros, O., & Harbottle, R. P. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-873-3_7 · Cited by 23
Organization of the immunity region immI of bacteriophage P1 and synthesis of the P1 antirepressor
Heisig, A., Riedel, H.-D., Dobrinski, B., Lurz, R., & Schuster, H. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90591-3 · Cited by 23
Usefulness of double gene construct for rapid identification of transgenic mice exhibiting tissue‐specific gene expression
Sato, M., Watanabe, T., Oshida, A., Nagashima, A., Miyazaki, J., & Kimura, M. (2001) · Molecular Reproduction and Development · doi:10.1002/mrd.1109 · Cited by 22

Authors: Sternberg, N., Sauer, B., Hoess, R., & Abremski, K.
Affiliations: Frederick National Laboratory for Cancer Research (US)
Venue: Journal of Molecular Biology
Publisher: Elsevier BV
Published: 1986-01
Volume: 187
Issue: 2
Pages: 197-212
ISSN: 0022-2836 (ISSN-L)
DOI: 10.1016/0022-2836(86)90228-7
OpenAlex: W1594256225
Cited by: 171
References: 36
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 7 · 2012: 4
FWCI: 20.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01co023909-011)
National Cancer Institute (N01-CO23909)
Topics: Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Keywords: bacteriophage P1, Cre recombinase, promoter, Dam methylation, RecA, lysogeny, vegetative growth, viral life cycle
MeSH terms: Base Sequence, Coliphages, DNA Nucleotidyltransferases, DNA, Viral, Gene Expression Regulation, Genes, Genes, Regulator, Genes, Viral, Lysogeny, Methylation, Mutation, Plasmids, Promoter Regions, Genetic, Suppression, Genetic, Transcription, Genetic, Protein Biosynthesis, Viral Proteins, Integrases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bacteriophage P1 cre gene and its regulatory region

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks