Non-enzymatic template-directed synthesis on RNA random copolymers

Improved Estimation of Secondary Structure in Ribonucleic Acids

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A Nonenzymatic RNA Polymerase Model

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Oligomerization of (guanosine 5′-phosphor)-2-methylimidazolide on poly(C)

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Non-enzymatic template-directed synthesis on RNA random copolymers

Joyce, G. F., Inoue, T., & Orgel, L. E. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90425-x · Cited by 178 · see citing works

Non-enzymic template-directed synthesis on RNA random copolymers

Joyce, G. F., & Orgel, L. E. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90166-x · Cited by 176 · see citing works

Efficient Metal-Ion Catalyzed Template-Directed Oligonucleotide Synthesis

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Substituent control of the poly(C)-directed oligomerization of guanosine 5'-phosphoroimidazolide

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Temperature-dependence of the template-directed synthesis of oligoguanylates

Fakhrai, H., Inoue, T., & Orgel, L. E. (1984) · Tetrahedron · doi:10.1016/0040-4020(84)85101-7 · Cited by 24 · see citing works

Template-directed synthesis on the oligonucleotide d(C7-G-C7)

Haertlé, T., & Orgel, L. E. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90482-1 · Cited by 13 · see citing works

Kinetics of cold-induced denaturation of metmyoglobin

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In-ice evolution of RNA polymerase ribozyme activity

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The Road to Non‐Enzymatic Molecular Networks

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Eutectic Phases in Ice Facilitate Nonenzymatic Nucleic Acid Synthesis

Kanavarioti, A., Monnard, P., & Deamer, D. W. (2001) · Astrobiology · doi:10.1089/15311070152757465 · Cited by 128 · see citing works

A viscous solvent enables information transfer from gene-length nucleic acids in a model prebiotic replication cycle

He, C., Gállego, I., Laughlin, B. P., Grover, M. A., & Hud, N. V. (2016) · Nature Chemistry · doi:10.1038/nchem.2628 · Cited by 76 · see citing works

Nonenzymatic Template-directed Synthesis of RNA from Monomers

Ia, K., & Orgel, L. E. (2000) · Molecular Biology · doi:10.1023/a:1026663422976 · Cited by 66 · see citing works

Expression of correctly processed human growth hormone in seeds of transgenic tobacco plants

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Metal-ion catalyzed polymerization in the eutectic phase in water–ice: A possible approach to template-directed RNA polymerization

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Surprising fidelity of template-directed chemical ligation of oligonucleotides

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From Prelife to Life: How Chemical Kinetics Become Evolutionary Dynamics

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Simultaneous origin of homochirality, the genetic code and its directionality

Root-Bernstein, R. S. (2007) · BioEssays · doi:10.1002/bies.20602 · Cited by 42 · see citing works

Nonenzymatic Recombination of RNA: Possible Mechanism for the Formation of Novel Sequences

Lutay, A., Аркадьевна, З. М., & Vlassov, V. V. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790062 · Cited by 39 · see citing works

Effects of Monomer and Template Concentration on the Kinetics of Nonenzymatic Template-Directed Oligoguanylate Synthesis

Kanavarioti, A., Bernasconi, C. F., & Baird, E. E. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9807237 · Cited by 38 · see citing works

Template-directed synthesis of oligonucleotides under eutectic conditions

Stribling, R., & Miller, S. L. (1991) · Journal of Molecular Evolution · doi:10.1007/bf02102186 · Cited by 37 · see citing works

Eutectic Phase in Water‐Ice: A Self‐Assembled Environment Conducive to Metal‐Catalyzed Non‐Enzymatic RNA Polymerization

Monnard, P., & Ziock, H. J. (2008) · Chemistry & Biodiversity · doi:10.1002/cbdv.200890141 · Cited by 36 · see citing works

Der Weg zu nichtenzymatischen molekularen Netzwerken

Dadon, Z., Wagner, N., & Ashkenasy, G. (2008) · Angewandte Chemie · doi:10.1002/ange.200702552 · Cited by 35 · see citing works

Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension

Duzdevich, D., Carr, C. E., Ding, D., Zhang, S. J., Walton, T., & Szostak, J. W. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab173 · Cited by 33 · see citing works

A steroid cap adjusts the selectivity and accelerates the rates of nonenzymatic single nucleotide extensions of an oligonucleotide

Rojas Stütz, J. A., & Richert, C. (2001) · Journal of the American Chemical Society · doi:10.1021/ja011448i · Cited by 30 · see citing works

Chemical primer extension: Individual steps of spontaneous replication

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Solvent viscosity facilitates replication and ribozyme catalysis from an RNA duplex in a model prebiotic process

He, C., Lozoya‐Colinas, A., Gállego, I., Grover, M. A., & Hud, N. V. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz496 · Cited by 27 · see citing works

DIMERIZATION IN HIGHLY CONCENTRATED SOLUTIONS OF PHOSPHOIMIDAZOLIDE ACTIVATED MONONUCLEOTIDES

Kanavarioti, A. (1997) · Origins of Life and Evolution of Biospheres · doi:10.1023/a:1006526002896 · Cited by 29 · see citing works

Attempted nonenzymatic template-directed oligomerizations on a polyadenylic acid template: Implications for the nature of the first genetic material

Stribling, R., & Miller, S. L. (1991) · Journal of Molecular Evolution · doi:10.1007/bf02102185 · Cited by 24 · see citing works

“RNA World”, a highly improbable scenario of the origin and early evolution of life on earth

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Taming Prebiotic Chemistry: The Role of Heterogeneous and Interfacial Catalysis in the Emergence of a Prebiotic Catalytic/Information Polymer System

Monnard, P. (2016) · Life · doi:10.3390/life6040040 · Cited by 18 · see citing works

Evolutionary Design of a DDPD Model of Ligation

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Self-replication of chemical systems based on recognition within a double or a triple helix: A realistic hypothesis

Kanavarioti, A. (1992) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80719-2 · Cited by 11 · see citing works

Supramolecular assembly-enabled homochiral polymerization of short (dA) n oligonucleotides

Mangalath, S., Karunakaran, S. C., Newnam, G. P., Schuster, G. B., & Hud, N. V. (2021) · Chemical Communications · doi:10.1039/d1cc05420a · Cited by 8 · see citing works

Ribozyme-Catalyzed Genetics

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Genome-wide identification of Kanamycin B binding RNA in Escherichia coli

Chang, Y., Sun, W., Murchie, A. I. H., & Chen, D. (2023) · BMC Genomics · doi:10.1186/s12864-023-09234-3 · Cited by 6 · see citing works

Sliding over the Blocks in Enzyme-Free RNA Copying – One-Pot Primer Extension in Ice

Löffler, P. M. G., Groen, J., Dörr, M., & Monnard, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075617 · Cited by 6 · see citing works

Simulations predict preferred Mg2+ coordination in a nonenzymatic primer-extension reaction center

Mittal, S., Nisler, C. R., & Szostak, J. W. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.04.032 · Cited by 5 · see citing works

Chapter 4 Evolutionary Design of a Model of Self-Assembling Chemical Structures

Buchanan, A., Gazzola, G., & Bedau, M. A. (2008) · Studies in multidisciplinarity · doi:10.1016/s1571-0831(07)00004-4 · Cited by 3 · see citing works

Modellsynthesen von Oligo- und Polynucleotiden

Kricheldorf, H. R. (2019) · Springer eBooks · doi:10.1007/978-3-662-57978-7_7 · Cited by 1 · see citing works

Origin of ribonucleotide recognition motifs through ligand mimicry at early earth

Mozumdar, D., & Roy, R. N. (2024) · RNA Biology · doi:10.1080/15476286.2024.2423149 · Cited by 1 · see citing works

Attempted non-enzymatic template-directed polymerizations of uridine and uridine analogs on polyadenosine: Implications for the nature of the first genetic material

Stribling, R., & Miller, S. L. (1989) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf02388875

Influence of Nucleic Acid on Racemisation of Peptide Synthesis by Water Soluble Carbodiimide and its Relevance to the Origin of Genetic Code

Podder, S., & Basu, H. S. (1990) · Springer eBooks · doi:10.1007/978-1-4613-0597-2_8

Model Syntheses of Oligo- and Polynucleotides

Kricheldorf, H. R. (2025) · Springer eBooks · doi:10.1007/978-3-662-70752-4_7

Non-enzymic template-directed synthesis on RNA random copolymers

Joyce, G. F., & Orgel, L. E. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90166-x · Cited by 176 · see citing works

Non-enzymatic template-directed synthesis of RNA copolymers

Joyce, G. F. (1984) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf00933711 · Cited by 15 · see citing works

Template-directed synthesis with 2-aminoadenosine

Grześkowiak, K., Webb, T. R., & Orgel, L. E. (1984) · Journal of Molecular Evolution · doi:10.1007/bf02100631 · Cited by 6 · see citing works

NON-ENZYMATIC TEMPLATE-DIRECTED SYNTHESIS OF RNA COPOLYMERS 1

Joyce, G. F. (1984)

Consequences of template self-structure in poly(C,G)-directed synthesis of oligo(G,C)s

Joyce, G. F., & Orgel, L. E. (1986) · Origins of Life and Evolution of Biospheres · doi:10.1007/bf02422133