Effects of chronic smoking on testosterone metabolism in dogs
Abstract
The effects of long-term cigarette smoking on androgen hydroxylases and peripheral hormones were studied in male beagles. In the testis, chronic smoking of high nicotine/tar cigarettes was associated with decreased activity of the 7 alpha-hydroxylase active on testosterone (68% of control, P less than 0.05). Testicular 6 beta and 16 alpha-hydroxylases were not altered. The hepatic androgen 6 beta-hydroxylase activity in control animals was approximately 6 times the testis levels and was stimulated markedly by smoking. This increase ranged from 221% in the low nicotine/tar group (P less than 0.02) to 304% in the high nicotine/tar group (P less than 0.006). Serum testosterone levels were reduced to 54% of control (P less than 0.02) and prostate size to 44% (P less than 0.001) of control with heavy smoking. Serum LH levels were elevated with smoking. These results suggest that chronic cigarette smoking increased hepatic metabolism of testosterone. In addition, serum testosterone levels and prostate size decreased and LH levels increased. Whether the hepatic and the endocrine effects are causally related cannot be determined from this preliminary study.
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Chronic smoking enhances intra-hepatic testosterone metabolism.
“These results indicate that chronic smoking enhances intra-hepatic testosterone metabolism”
From Effects of Smoking Cessation on Hormonal Levels in Men (2013) · cites this paper as Mittler et al. 1983
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Mendelson, J. H., Sholar, M. B., Mutschler, N. H., Jaszyna-Gasior, M., Goletiani, N. V., Siegel, A. J., & Mello, N. K. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052928 · Cited by 81 · see citing works
Nicotine and cotinine inhibit rat testis androgen biosynthesis in vitro
yeh, J., Barbieri, R. L., & Friedman, A. J. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90051-4 · Cited by 42 · see citing works
Effects of Smoking Cessation on Hormonal Levels in Men
HRUŠKOVIČOVÁ, H., DUŠKOVÁ, M., ŠIMŮNKOVÁ, K., HILL, M., POSPÍŠILOVÁ, H., RÁCZ, B., KRÁLÍKOVÁ, E., VONDRA, K., & STÁRKA, L. (2013) · Physiological Research · doi:10.33549/physiolres.932326 · Cited by 17 · see citing works
The Steroid Spectrum During and After Quitting Smoking
JANDIKOVA, H., DUSKOVA, M., SIMUNKOVA, K., RACZ, B., HILL, M., KRALIKOVA, E., VONDRA, K., & STARKA, L. (2015) · Physiological Research · doi:10.33549/physiolres.933068 · Cited by 11 · see citing works
- Authors
- Mittler, J. C., Pogach, L., & Ertel, N. H.
- Affiliations
- VA New Jersey Health Care System (US)
- ORCID
- Pogach, L.
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1983-06
- Volume
- 18
- Issue
- 6
- Pages
- 759-763
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W2035553150
- Cited by
- 31
- References
- 0
- Citations by year
- 2018: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- chronic cigarette smoking, testosterone metabolism, 7alpha-hydroxylase, 16alpha-hydroxylase, hepatic steroid metabolism, testicular steroidogenesis, serum testosterone, prostate volume, luteinizing hormone, nicotine, tar, beagle dogs
- MeSH terms
- Animals, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 Enzyme System, Dogs, Luteinizing Hormone, Liver, Male, Nicotine, Prostate, Smoking, Steroid Hydroxylases, Tars, Testis, Testosterone, Steroid 16-alpha-Hydroxylase
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