The Steroid Spectrum During and After Quitting Smoking
Open accessAbstract
Addiction to tobacco results in an imbalance of endocrine homeostasis in both sexes. This can also have impacts on fertility problems. The male reproductive system is less susceptible than that of females, with a worsening spermiogram in smokers, the most cited effect in the literature. However, the literature is inconsistent as to the effects of smoking on steroid hormone levels in men, and there is very little data on the effects of quitting smoking in men. In this study we followed 76 men before quitting smoking, and then after 6, 12, and 24 weeks and 1 year of abstinence. We measured basic anthropomorphic data and steroid hormone levels along with steroid neuroactive metabolites using GC-MS. We demonstrate lower androgen levels in men who smoke, and these changes worsened after quitting smoking. There was a drop in SHBG already in the first week of non-smoking, and levels continued to remain low. Male smokers have lower androgen levels compared to non-smokers. The lower the initial level of androgen, the lower the likelihood of success in quitting smoking. Changes in steroid hormones proved to be a promising marker for the prediction of success in quitting smoking.
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The effects of smoking on testosterone are controversial: many studies show no effect on total testosterone levels, whereas others show a direct correlation between serum testosterone levels and nicotine levels.
“The effects of smoking on testosterone are controversial. According to many studies, smoking does not seem to have an effect on total testosterone levels, which remain unchanged between smokers and non-smokers; whereas according to others, there is a direct correlation between serum testosterone levels and nicotine levels [35].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [35]
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Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic
Tarantino, U., Cariati, I., Greggi, C., Gasbarra, E., Belluati, A., Ciolli, L., Maccauro, G., Momoli, A., Ripanti, S., Falez, F., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126629 · Cited by 52 · see citing works
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- Authors
- JANDIKOVA, H., DUSKOVA, M., SIMUNKOVA, K., RACZ, B., HILL, M., KRALIKOVA, E., VONDRA, K., & STARKA, L.
- Affiliations
- Institute of Endocrinology, Prague, Czech Republic
- Institute of Endocrinology (CZ)
- ORCID
- HILL, M.
- Venue
- Physiological Research
- Published
- 2015-10-14
- Volume
- 64
- Issue
- Suppl 2
- Pages
- S211-S218
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2489922310
- Cited by
- 11
- References
- 27
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2018: 2 · 2017: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- smoking cessation, tobacco dependence, steroid hormones, androgens, sex hormone-binding globulin, male reproductive health, semen quality, endocrine homeostasis
- MeSH terms
- Adult, Humans, Male, Middle Aged, Prospective Studies, Sex Hormone-Binding Globulin, Smoking, Testosterone, Smoking Cessation
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