Nicotine and cotinine inhibit rat testis androgen biosynthesis in vitro

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Leydig Cell Function in Normal Men: Effect of Age, Life-Style, Residence, Diet, and Activity*

DESLYPERE, J. P., & VERMEULENf, A. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-5-955 · Cited by 343 · see citing works

Effect of LH on Steroidogenesis and Cyclic AMP Accumulation in Rat Leydig Cell Preparations and Mouse Tumor Leydig Cells

Moyle, W. R., & Ramachandran, J. (1973) · Endocrinology · doi:10.1210/endo-93-1-127 · Cited by 198 · see citing works

Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.

Barbieri, R. L., Gochberg, J., & Ryan, K. J. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112494 · Cited by 197 · see citing works

The Spectrophotometric Measurement of Turbid Suspensions of Cytochromes Associated with Drug Metabolism

Estabrook, R. W., Peterson, J. A., Baron, J., & Hildebrandt, A. G. (1972) · Springer eBooks · doi:10.1007/978-1-4757-0196-8_9 · Cited by 161 · see citing works

Endocrine profile and semen characteristics in male smokers

Shaarawy, M., & Mahmoud, K. Z. (1982) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46470-8 · Cited by 135 · see citing works

The Effects of Dexamethasone on the Peripheral Plasma Concentrations of Androstenedione, Testosterone and Cortisol in the Pregnant Rhesus Monkey

Challis, J. R. G., DAVIES, I. J., Benirschke, K., Hendrickx, A. G., & Ryan, K. J. (1975) · Endocrinology · doi:10.1210/endo-96-1-185 · Cited by 70 · see citing works

Studies of cytochrome P-450 in testis microsomes

Menard, R. H., & Purvis, J. L. (1973) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(73)90029-5 · Cited by 64 · see citing works

Nicotinic Cholinergic Agonists Inhibit Androgen Biosynthesis by Cultured Rat Testicular Cells*

Kasson, B. G., & Hsueh, A. J. W. (1985) · Endocrinology · doi:10.1210/endo-117-5-1874 · Cited by 33 · see citing works

Effects of chronic smoking on testosterone metabolism in dogs

Mittler, J. C., Pogach, L., & Ertel, N. H. (1983) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(83)90256-x · Cited by 31 · see citing works

Presence of a low molecular weight inhibitor of succinate-supported cholesterol side chain cleavage in rat ovaries

Toaff, M. E., Schleyer, H., & Strauss, J. F. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90172-1 · Cited by 17 · see citing works

The effects of nicotine, cotinine and anabasine on rat adrenal 11β-hydroxylase and 21-hydroxylase

Barbieri, R. L., York, C. M., Cherry, M. L., & Ryan, K. J. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90119-1 · Cited by 14 · see citing works

Pharmacology of Nicotine: Addiction and Therapeutics

Benowitz, N. L. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.003121 · Cited by 589 · see citing works

Longitudinal Relation between Endogenous Testosterone and Cardiovascular Disease Risk Factors in Middle-aged Men: A 13-Year Follow-up of Former Multiple Risk Factor Intervention Trial Participants

Zmuda, J. M., Cauley, J. A., Kriska, A. M., Glynn, N. W., Gutai, J. P., & Kuller, L. H. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009326 · Cited by 362 · see citing works

Prenatal effects of maternal smoking on daughters' smoking: nicotine or testosterone exposure?

Kandel, D. B., & Udry, J. R. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.9.1377 · Cited by 87 · see citing works

Substance Abuse and Male Hypogonadism

Duca, Y., Aversa, A., Condorelli, R. A., Calogero, A. E., & Vignera, S. L. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050732 · Cited by 83 · see citing works

Withdrawal from chronic nicotine in adolescent and adult rats

Wilmouth, C. E., & SPEAR, L. P. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.10.021 · Cited by 65 · see citing works

Adrenal-mediated rather than direct effects of nicotine as a basis of altered sex steroid synthesis in fetal and neonatal rat

Sarasin, A. (2003) · Reproductive Toxicology · doi:10.1016/s0890-6238(02)00119-3 · Cited by 55 · see citing works

Chapter Two Pyridine and piperidine alkaloids: An update

Schneider, M. J. (1996) · Alkaloids: chemical and biological perspectives · doi:10.1016/s0735-8210(96)80026-4 · Cited by 53 · see citing works

Protective Effect of Selenium on Nicotine-Induced Testicular Toxicity in Rats

Seema, P. V., Swathy, S. S., & Indira, M. (2007) · Biological Trace Element Research · doi:10.1007/s12011-007-8021-7 · Cited by 49 · see citing works

Nicotine induces apoptosis in TM3 mouse Leydig cells

Kim, K. H., Joo, K.-J., Park, H.-J., Kwon, C.-H., Jang, M.-H., & Kim, C. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.12.013 · Cited by 48 · see citing works

Nicotine-induced damages in testicular tissue of rats; evidences for bcl-2, p53 and caspase-3 expression.

Mosadegh, M., Hasanzadeh, S., & Razi, M. (2017) · PubMed Central · doi:10.22038/ijbms.2017.8249 · Cited by 45 · see citing works

Clinical pharmacology of oral cotinine

Zevin, S., Jacob, P., Geppetti, P., & Benowitz, N. L. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)80003-4 · Cited by 40 · see citing works

Nicotine affects rat Leydig cell function in vivo and vitro via down-regulating some key steroidogenic enzyme expressions

Guo, X., Wang, H., Wu, X., Chen, X., Chen, Y., Guo, J., Li, X., Lian, Q., & Ge, R.-S. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.09.055 · Cited by 38 · see citing works

Reduced testicular steroidogenesis in rat offspring by prenatal nicotine exposure: Epigenetic programming and heritability via nAChR/HDAC4

Qi, Z., Pei, L., Liu, M., Lv, F., Chen, G., & Wang, H. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.111057 · Cited by 38 · see citing works

Effect of nicotine on spermatogenesis in adult albino rats

Nesseim, W., Haroun, H. S., Mostafa, E., Youakim, M. F., & Mostafa, T. (2011) · Andrologia · doi:10.1111/j.1439-0272.2010.01086.x · Cited by 36 · see citing works

Prenatal and early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile male mice

Yanai, S., Hirano, T., Omotehara, T., TAKADA, T., YONEDA, N., KUBOTA, N., YAMAMOTO, A., MANTANI, Y., YOKOYAMA, T., KITAGAWA, H., et al. (2017) · Journal of Veterinary Medical Science · doi:10.1292/jvms.17-0154 · Cited by 34 · see citing works

Effect of acetamiprid on the immature murine testes

Terayama, H., Qu, N., Endo, H., Ito, M., Tsukamoto, H., Umemoto, K., Kawakami, S., Fujino, Y., Tatemichi, M., & Sakabe, K. (2018) · International Journal of Environmental Health Research · doi:10.1080/09603123.2018.1504897 · Cited by 33 · see citing works

Effects of Smoking on Plasma Testosterone Level and Erectile Function in Rats

Park, M. G., Ko, K. W., Oh, M. M., Bae, J. H., Kim, J. J., & Moon, D. G. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02555.x · Cited by 25 · see citing works

Nicotine and its major metabolite continine have different effects on aldosterone and prolactin serum levels in the normal male rat

Andersson, K., Jansson, A., Kuylenstierna, F., & Eneroth, P. H. E. (1993) · European Journal of Pharmacology Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(93)90065-x · Cited by 23 · see citing works

An efficient microwave-assisted synthesis of cotinine and iso-cotinine analogs from an Ugi-4CR approach

Polindara‐García, L. A., Montesinos‐Miguel, D., & Vázquez, A. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01170a · Cited by 21 · see citing works

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

Li, S., Lu, D., Zhang, Y., & Zhang, Y. (2013) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-0102-2 · Cited by 21 · see citing works

Pharmacology of Nicotine

Benowitz, N. L. (1998) · Springer eBooks · doi:10.1007/978-1-4757-2913-9_20 · Cited by 21 · see citing works

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

McArt, D. G., Dunne, P. D., Blayney, J. K., Salto‐Tellez, M., Schaeybroeck, S. V., Hamilton, P. W., & Zhang, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066902 · Cited by 20 · see citing works

Time-course of extracellular nicotine and cotinine levels in rat brain following administration of nicotine: effects of route and ethanol coadministration

Katner, S. N., Toalston, J. E., Smoker, M. P., Rodd, Z. A., McBride, W. J., & Engleman, E. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3681-4 · Cited by 16 · see citing works

Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes

Piontek, U., Wallaschofski, H., Kastenmüller, G., Suhre, K., Völzke, H., Do, K. T., Artati, A., Nauck, M. A., Adamski, J., Friedrich, N., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02367-y · Cited by 15 · see citing works

Acute Biological Effects of Nicotine and Its Metabolites

Benowitz, N. L. (1995) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7445-8_2 · Cited by 15 · see citing works

Inhibition of aldosterone synthesis in rat adrenal cells by nicotine and related constituents of tobacco smoke

Skowroński, R., & Feldman, D. (1994) · Endocrinology · doi:10.1210/en.134.5.2171 · Cited by 15 · see citing works

The Smoky Impact of Nicotinic Acetylcholine Receptors on Testicular Function

Barbagallo, F., Assenza, M. R., Torrisi, F., Buonacquisto, A., & Pallotti, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175097 · Cited by 14 · see citing works

Competitive Inhibition of Human Placental Aromatase by N-n-Octanoylnornicotine and Other Nornicotine Derivatives

Bullion, K. A., Ohnishi, S., & Osawa, Y. (1991) · Endocrine Research · doi:10.3109/07435809109106817 · Cited by 13 · see citing works

Plasma 17-α-OH-progesterone in Male Workers Exposed to Traffic Pollutants

Tomei, G., Ciarrocca, M., BERNARDINI, A., Capozzella, A., Rosati, M. V., Anzelmo, V., Caciari, T., Cardella, C., Monti, C., & Tomei, F. (2007) · Industrial Health · doi:10.2486/indhealth.45.170 · Cited by 11 · see citing works

Fetal Drug Exposure and Sexual Differentiation of Males

Ward, O. B. (1992) · Handbook of behavioral neurobiology · doi:10.1007/978-1-4899-2453-7_6 · Cited by 10 · see citing works

Androgen Receptor and Ultrastructural Features of Nigella sativa Oil and Nicotine-Treated Male Rat Reproductive Glands

Lina, S., Eliza, H., Hashida, N. H., Ibrahim, S. F., & Osman, K. (2018) · Sains Malaysiana · doi:10.17576/jsm-2018-4708-22 · Cited by 9 · see citing works

Cisatracurium stimulates testosterone synthesis in rat and mouse Leydig cells via nicotinic acetylcholine receptor

Ni, C., Li, Y., Li, Z., Tian, L., Fu, J., Wu, K., Wang, Y., Yao, M., & Ge, R. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16029 · Cited by 8 · see citing works

Sex Hormones (Male): Analogs and Antagonists

Brueggemeier, R. W. (2006) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.200500066 · Cited by 8 · see citing works

Nicotine

Henningfield, J. E., Keenan, R. M., & Clarke, P. B. S. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60963-3_8 · Cited by 7 · see citing works

Male Sex Hormones, Analogs, and Antagonists

Brueggemeier, R. W. (2003) · Wiley eBooks · doi:10.1002/0471266949.bmc055 · Cited by 7 · see citing works

Prevalence and predictors for low total testosterone levels among male type 2 diabetic patients: an Egyptian experience

Aboelnaga, M. M., & Elshahawy, H. A. (2016) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20162298 · Cited by 4 · see citing works

E-cigarette vapor extract alters human eosinophil gene expression in an effect mediated by propylene glycol, glycerin, and nicotine

Hogan, N. T., Castañeda-Castro, F. E., Premlal, A. L. R., Brickner, H., Mondal, M., de la Mata, S. H., Vijayanand, P., Alexander, L. E. C., Seumois, G., & Akuthota, P. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae176 · Cited by 4 · see citing works

Cotinine inhibits catecholamine release evoked by cholinergic stimulation from the rat adrenal medulla

Koh, Y.-Y., Jang, S.-J., & Lim, D. (2003) · Archives of Pharmacal Research · doi:10.1007/bf02976686 · Cited by 3 · see citing works

Multiomics Mendelian Randomization Reveals Causal Oxidative Stress Genes in Androgenetic Alopecia

Zhu, Y., Zhao, C., He, Y. L., Lu, M., Luo, R., Wang, Z., Jia, L., Li, Z., Jiang, H., & Li, Y. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.08.014 · Cited by 2 · see citing works

Residual Risk of Nicotine

Mathis, C., Smart, D. J., Xia, W., Phillips, B. W., Peitsch, M. C., Szostak, J., Poussin, C., & Luettich, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820490-0.00022-5 · Cited by 1 · see citing works

EFFECT OF NICOTINE ON SPERMATOGENESIS IN ADULT ALBINO RAT

Nesseim, W., Haroun, H. S., Mostafa, M., & Youakim, M. F. (2004) · The Egyptian Journal of Anatomy · doi:10.21608/ejana.2004.5896

EFFECT OF NICOTINE AND CADMIUM ON TESTES, DUCT SYSTEM AND EPIDIDYMAL SPERM’S DNA INTEGRITY IN RATS

Batool, S. (2009)

The effects of nicotine, cotinine and anabasine on rat adrenal 11β-hydroxylase and 21-hydroxylase

Barbieri, R. L., York, C. M., Cherry, M. L., & Ryan, K. J. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90119-1 · Cited by 14 · see citing works

Nicotine and cotinine inhibit steroidogenesis in mouse leydig cells

Patterson, T. R., Stringham, J. D., & Meikle, A. W. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90032-m · Cited by 60 · see citing works

Nicotine affects rat Leydig cell function in vivo and vitro via down-regulating some key steroidogenic enzyme expressions

Guo, X., Wang, H., Wu, X., Chen, X., Chen, Y., Guo, J., Li, X., Lian, Q., & Ge, R.-S. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.09.055 · Cited by 38 · see citing works

Nicotine and cotinine effects on 3 alpha hydroxysteroid dehydrogenase in canine prostate

Meikle, A. W., Liu, X. H., Taylor, G. N., & Stringham, J. D. (1988) · Life Sciences · doi:10.1016/s0024-3205(88)80001-8 · Cited by 45 · see citing works

Physician knowledge of teratology: an assessment of their counseling approach to four standard case scenarios

Rissman, A., & Pergament, E. (1993) · Reproductive Toxicology · doi:10.1016/0890-6238(93)90042-6