The cellular effects of estrogens on neuroendocrine tissues
Open accessAbstract
Estrogen action on sensitive neurons in the rat diencephalon has been studied by morphologic techniques; evidence of estrogen action at every level is presented, including tracts, cells, circuitry and subcellular organelles. The demonstration in the arcuate nucleus of estrogen-induced synaptic remodelling, estrogen-induced postsynaptic membrane phenotypes, changes in intracellular membranes and rapid estrogen actions on neuronal endo-exocytosis indicates that cellular estrogen actions may underlie the neuronal control of reproduction.
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Estrogen exerts a negative feedback on the hypothalamic-pituitary axis and decreases the release of FSH from the pituitary gland.
“Estrogen exerts a negative feedback on the hypothalamicpituitary axis and decreases the release of FSH from the pituitary gland (42)(43)(44)(45)(46).”
From A new era in ovulation induction (2006) · cites this paper as [45]
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- Authors
- Naftolin, F., Maclusky, N. J., Leranth, C. Z., Sakamoto, H. S., & Garcia-Segura, L. M.
- Affiliations
- Yale University (US)
- Corresponding author
- Naftolin, F.
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1988
- Volume
- 30
- Issue
- 1-6
- Pages
- 195-207
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W1972516854
- Cited by
- 86
- References
- 97
- Citations by year
- 2025: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Steroid Biochemistry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 13587)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- estrogen, neuroendocrine tissues, diencephalon, arcuate nucleus, synaptic remodeling, postsynaptic membrane, intracellular membranes, neuronal exocytosis
- MeSH terms
- Animals, Brain, Estrogens, Female, Male, Models, Biological, Neurons, Neurosecretory Systems
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