Pharmacology of Nicotine: Addiction and Therapeutics

Signs and Symptoms of Tobacco Withdrawal

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Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data.

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A meta-analysis of the role of smoking in inflammatory bowel disease

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The antiestrogenic effect of cigarette smoking in women

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Evidence that Tobacco Smoking Increases the Density of (−)‐[³H]Nicotine Binding Sites in Human Brain

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The effectiveness of the nicotine patch for smoking cessation. A meta-analysis

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Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons

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Transdermal Nicotine for Active Ulcerative Colitis

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The Bone Density of Female Twins Discordant for Tobacco Use

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Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes.

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Higher levels of nicotine in arterial than in venous blood after cigarette smoking

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The paradox of nicotinic acetylcholine receptor upregulation by nicotine

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Characterization of Nicotinic Receptor‐Mediated [³H]Dopamine Release from Synaptosomes Prepared from Mouse Striatum

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Cigarette smoking and Parkinson's disease

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Randomised controlled trial of nasal nicotine spray in smoking cessation

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Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone

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Smoking-induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alterations in coronary artery tone.

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The effects of cigarette smoking on pain and anxiety

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How effective is nicotine replacement therapy in helping people to stop smoking?

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Nicotine effects on eicosanoid formation and hemostatic function: Comparison of transdermal nicotine and cigarette smoking

Benowitz, N. L., FitzGerald, G. A., Wilson, M., & Zhang, Q. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90431-y · Cited by 195 · see citing works

Acute effect of cigarette smoking on the coronary circulation: Constriction of epicardial and resistance vessels

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Transdermal Nicotine as Maintenance Therapy for Ulcerative Colitis

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Effects of cigarette smoking and its cessation on lipid metabolism and energy expenditure in heavy smokers.

Hellerstein, M., Benowitz, N., Neese, R., Schwartz, J. M., Hoh, R., Jacob, P., Hsieh, J., & Faix, D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116955 · Cited by 164 · see citing works

Metabolic effects of cigarette smoking.

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Nicotine may relieve symptoms of Parkinson's disease

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Effectiveness of a 16-hour transdermal nicotine patch in a medical practice setting, without intensive group counseling.

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Inverse relation between serum cotinine concentration and blood pressure in cigarette smokers.

Benowitz, N. L., & Sharp, D. S. (1989) · Circulation · doi:10.1161/01.cir.80.5.1309 · Cited by 131 · see citing works

A low dose of subcutaneous nicotine improves information processing in non-smokers

Houezec, J. L., Halliday, R. A., Benowitz, N. L., Callaway, E., Naylor, H., & Herzig, K. E. (1994) · Psychopharmacology · doi:10.1007/bf02244994 · Cited by 130 · see citing works

Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3'-hydroxycotinine in smokers.

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Smoking Eliminates the Protective Effect of Oral Estrogens on the Risk for Hip Fracture among Women

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Role of nicotine dose and sensory cues in the regulation of smoke intake

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The effect of cigarette smoking on adrenal cortical hormones.

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Cigarette smoking and cognitive performance

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Relation between tobacco use and urinary excretion of thromboxane A2 and prostacyclin metabolites in young men.

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Genetic and environmental aspects of the role of nicotinic receptors in neurodegenerative disorders: Emphasis on Alzheimer's disease and Parkinson's disease

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Pituitary hormone response to cigarette smoking

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The Effect of Chronic Nicotine Administration on Bone Mineral Content in Mice

Broulik, P. D., & Jařáb, J. (1993) · Hormone and Metabolic Research · doi:10.1055/s-2007-1002080 · Cited by 95 · see citing works

Apparent tolerance to the acute effect of nicotine results in part from distribution kinetics.

Porchet, H. C., Benowitz, N. L., Sheiner, L. B., & Copeland, J. R. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113227 · Cited by 88 · see citing works

Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion.

Collins, A. C., Luo, Y., Selvaag, S., & Marks, M. J. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22727-6 · Cited by 81 · see citing works

Nicotine Skin Patch Treatment Increases Abstinence, Decreases Withdrawal Symptoms, and Attenuates Rewarding Effects of Smoking

Levin, E. D., Westman, E. C., STEIN, R. M., Carnahan, E., SANCHEZ, M., Herman, S., Behm, F. M., & Rose, J. E. (1994) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199402000-00006 · Cited by 77 · see citing works

Spontaneous EEG changes during tobacco abstinence and nicotine substitution in human volunteers.

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Chronic nicotine treatment increases dopamine levels and reduces dopamine utilization in substantia nigra and in surviving forebrain dopamine nerve terminal systems after a partial di-mesencephalic hemitransection

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Transdermal nicotine: reduction of smoking with minimal abuse liability

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On the action of nicotine and cotinine on central 5-hydroxytryptamine neurons

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Deficient C-oxidation of nicotine*

Benowitz, N. L., Jacob, P., & Sachs, D. P. L. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90044-6 · Cited by 63 · see citing works

A reevaluation of estrogen status in postmenopausal women who smoke

Cassidenti, D. L., Pike, M. C., Vijod, A. G., Stanczyk, F. Z., & Løbo, R. A. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91617-j · Cited by 60 · see citing works

Effect of nicotine on coronary blood‐flow in man

Kaijser, L., & Berglund, B. (1985) · Clinical Physiology · doi:10.1111/j.1475-097x.1985.tb00767.x · Cited by 59 · see citing works

Absolute bioavailability of nicotine applied to different nasal regions

Johansson, C.-J., Olsson, P., Bende, M., Carlsson, T., & Gunnarsson, P. O. (1991) · European Journal of Clinical Pharmacology · doi:10.1007/bf00314989 · Cited by 49 · see citing works

Binding of optically pure (−)‐[3H]nicotine to rat brain membranes

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Preferential Metabolic Activation of Subcortical Brain Areas by Acute Administration of Nicotine to Rats

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Nicotine and cotinine inhibit rat testis androgen biosynthesis in vitro

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Effects of Nicotine on Platelet Function

Pfueller, S. L., Burns, P., Mak, K., et al. (2009) · Haemostasis · doi:10.1159/000215800 · Cited by 41 · see citing works

Nicotine does not affect plasma lipoprotein concentrations in healthy men

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Effects of nicotine and its major metabolites on blood pressure in anaesthetized rats

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Divergent tolerance to metabolic and cardiovascular effects of nicotine in smokers with low and high levels of cigarette consumption

Arcavi, L., Jacob, P., Hellerstein, M. K., & Benowitz, N. L. (1994) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1994.101 · Cited by 33 · see citing works

Characterization of [3H]ABT-418: a novel cholinergic channel ligand.

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Acute effects of low dose nicotine gum on platelet function in non-smoking hypertensive and normotensive men

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Is Clonidine an Effective Smoking Cessation Therapy?

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Protein kinase A regulates nicotinic cholinergic receptors and subunit messenger ribonucleic acids in PC 12 cells.

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The effects of nicotine, cotinine and anabasine on rat adrenal 11β-hydroxylase and 21-hydroxylase

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Race and unhealthy behaviors: chronic stress, the HPA axis, and physical and mental health disparities over the life course

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Guidelines on nicotine dose selection for in vivo research

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Variants in Nicotinic Receptors and Risk for Nicotine Dependence

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Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

S. Watkins, G. F. K. (2000) · Nicotine & Tobacco Research · doi:10.1080/14622200050011277 · Cited by 424 · see citing works

The neurocircuitry of addiction: an overview

Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works

Neurobiology of Nicotine Addiction: Implications for Smoking Cessation Treatment

Benowitz, N. L. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.01.015 · Cited by 385 · see citing works

Risks and Benefits of Nicotine to Aid Smoking Cessation in Pregnancy

Dempsey, D. A., & Benowitz, N. L. (2001) · Drug Safety · doi:10.2165/00002018-200124040-00005 · Cited by 346 · see citing works

Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction

Govind, A. P., Vezina, P., & Green, W. N. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.011 · Cited by 338 · see citing works

Allosteric Sensitization of Nicotinic Receptors by Galantamine, a New Treatment Strategy for Alzheimer’s Disease

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Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT_3A) and Nicotinic Acetylcholine Receptors:  The Anomalous Binding Properties of Nicotine

Beene, D. L., Brandt, G. S., Zhong, W., Zacharias, N. M., Lester, H. A., & Dougherty, D. A. (2002) · Biochemistry · doi:10.1021/bi020266d · Cited by 300 · see citing works

A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity

Maurer, P., Jennings, G. T., Willers, J., Rohner, F., Lindman, Y., Roubicek, K., Renner, W. A., Müller, P., & Bachmann, M. F. (2005) · European Journal of Immunology · doi:10.1002/eji.200526285 · Cited by 279 · see citing works

Nicotine acts as a pharmacological chaperone to up-regulate human α4β2 acetylcholine receptors

Kuryatov, A., Luo, J., Cooper, J., & Lindstrom, J. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012419 · Cited by 275 · see citing works

Roles of "wanting" and "liking" in motivating behavior: gambling, food, and drug addictions

Robinson, M. J. F., Fischer, A. M., Ahuja, A., Lesser, E. N., & Maniates, H. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_387 · Cited by 247 · see citing works

The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence

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Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism

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Roles of Accessory Subunits in α4β2* Nicotinic Receptors

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Chronic Nicotine Treatment Up-regulates Human α3β2 but Not α3β4 Acetylcholine Receptors Stably Transfected in Human Embryonic Kidney Cells

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Estimating the cost of a smoking employee

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Acetylcholine Receptor (AChR) α5 Subunit Variant Associated with Risk for Nicotine Dependence and Lung Cancer Reduces (α4β2)2α5 AChR Function

Kuryatov, A., Berrettini, W., & Lindstrom, J. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.066357 · Cited by 171 · see citing works

A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex

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Nicotinic Acetylcholine Receptors in Sensory Cortex: Figure 1

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Nicotine metabolism and elimination kinetics in newborns

Dempsey, D. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.106129 · Cited by 112 · see citing works

Individualizing Nicotine Replacement Therapy for the Treatment of Tobacco Dependence: A Randomized Trial

Lerman, C., Kaufmann, V., Rukstalis, M., Patterson, F., Perkins, K., Audrain-McGovern, J., & Benowitz, N. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-6-200403160-00009 · Cited by 110 · see citing works

Untitled work

Zvolensky (2001) · doi:10.1016/s0306-4603(01)00242-8 · Cited by 96 · see citing works

Increases in hyperactive-impulsive symptoms predict relapse among smokers in nicotine replacement therapy

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β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic α6* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines

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Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior

Hellberg, S. N., Russell, T. I., & Robinson, M. J. F. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-00662-3 · Cited by 65 · see citing works

Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats

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Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats

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DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Effects and Withdrawal of Drug Addiction

Li, D., & Ma, X. (2023) · Journal of Education Humanities and Social Sciences · doi:10.54097/ehss.v8i.4502

The epidemiological and genetic study of nicotine addiction

Xiao, Q. (2004) · Chinese Journal of Disease Control and Prevention

A Study on Big Data Analytics Tools

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