The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Increase of plasma IL-6 concentration with age in healthy subjects
Abstract
The present study demonstrated that plasma IL-6 concentration was higher in older subjects than in younger ones and significantly in the male group (P = 0.02); Spearman rank correlation showed that plasma IL-6 concentration was positively correlated with age (r = 0.28, N = 55, P < 0.05); there was a highly significant correlation between the concentrations in plasma IL-6 and IL-1 alpha (r = 0.51, N = 52, P < 0.001). These findings suggest the possibility that age-related changes of plasma IL-6 and IL-1 alpha may provide a pathological basis for the susceptibility to such illness as commonly occurs in elderly people, especially Alzheimer's disease as the two interleukins can induce the production of alpha 1-antichymotrypsin and beta-amyloid protein precursor.
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“In vitro, vitamin D modulates the pro-inflammatory profile of monocytes/macrophages from type 2 diabetic patients (733) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [733]
Citations
Cites
Interleukin-6 and the acute phase response
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CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES
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Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
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Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
George‐Hyslop, P. S., Haines, J. L., Farrer, L. A., Polinsky, R. J., Broeckhoven, C. V., Goate, A., McLachlan, D. R. C., Orr, H. T., Bruni, A. C., Sorbi, S., et al. (1990) · Nature · doi:10.1038/347194a0 · Cited by 396
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Blood to brain transport of interleukin links the immune and central nervous systems
Banks, W. A., & Kastin, A. J. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90385-o · Cited by 177
Age-associated increase in interleukin 6 in MRL/lpr mice
Tang, B., Matsuda, T., Akira, S., Nagata, N., Ikehara, S., Hirano, T., & Kishimoto, T. (1991) · International Immunology · doi:10.1093/intimm/3.3.273 · Cited by 159
Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease
van Duijn, C. M., Hofman, A., & Nagelkerken, L. M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90666-w · Cited by 79
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Neuroimmunomodulation takes off
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Research works printed but not linked: 3
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Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Evidence for prescribing exercise as therapy in chronic disease
Pedersen, B. K., & Saltin, B. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00520.x · Cited by 1,384
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267
Metadata
- Authors
- Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P.
- ORCID
- Wei, Jun
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 51
- Issue
- 25
- Pages
- 1953-1956
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2040015087
- Cited by
- 402
- References
- 13
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 17 · 2023: 20 · 2022: 15 · 2021: 19 · 2020: 18 · 2019: 16 · 2018: 6 · 2017: 13 · 2016: 11 · 2015: 13 · 2014: 13 · 2013: 21 · 2012: 12
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- History & Philosophy of the Life Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- interleukin-6, interleukin-1 alpha, aging, plasma cytokine concentrations, sex differences, Alzheimer's disease, alpha-1-antichymotrypsin
- MeSH terms
- Adult, Aged, Aging, Female, Humans, Interleukin-1, Male, Middle Aged, Radioimmunoassay, Sex Factors, Interleukin-6
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