Cited by 402Cytokine Signaling Pathways and InteractionsNeuroinflammation and Neurodegeneration MechanismsAdipokines, Inflammation, and Metabolic Diseases

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Increase of plasma IL-6 concentration with age in healthy subjects

Wei, Jun, Xu, Haimin, Davies, Jane L., Hemmings, Gwynneth P.·1992·Life Sciences

DOI 10.1016/0024-3205(92)90112-3

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Abstract

The present study demonstrated that plasma IL-6 concentration was higher in older subjects than in younger ones and significantly in the male group (P = 0.02); Spearman rank correlation showed that plasma IL-6 concentration was positively correlated with age (r = 0.28, N = 55, P < 0.05); there was a highly significant correlation between the concentrations in plasma IL-6 and IL-1 alpha (r = 0.51, N = 52, P < 0.001). These findings suggest the possibility that age-related changes of plasma IL-6 and IL-1 alpha may provide a pathological basis for the susceptibility to such illness as commonly occurs in elderly people, especially Alzheimer's disease as the two interleukins can induce the production of alpha 1-antichymotrypsin and beta-amyloid protein precursor.

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Authors: Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P.
ORCID: Wei, Jun
Venue: Life Sciences
Publisher: Elsevier BV
Published: 1992-01
Volume: 51
Issue: 25
Pages: 1953-1956
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/0024-3205(92)90112-3
OpenAlex: W2040015087
Cited by: 402
References: 13
Citations by year: 2026: 4 · 2025: 6 · 2024: 17 · 2023: 20 · 2022: 15 · 2021: 19 · 2020: 18 · 2019: 16 · 2018: 6 · 2017: 13 · 2016: 11 · 2015: 13 · 2014: 13 · 2013: 21 · 2012: 12
FWCI: 2.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
History & Philosophy of the Life Sciences
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: interleukin-6, interleukin-1 alpha, aging, plasma cytokine concentrations, sex differences, Alzheimer's disease, alpha-1-antichymotrypsin
MeSH terms: Adult, Aged, Aging, Female, Humans, Interleukin-1, Male, Middle Aged, Radioimmunoassay, Sex Factors, Interleukin-6

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Increase of plasma IL-6 concentration with age in healthy subjects

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