Cited by 243Cannabis and Cannabinoid ResearchHypothalamic control of reproductive hormonesEstrogen and related hormone effects

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement.

de Fonseca, F.Rodríguez, Cebeira, M., Ramos, J.A., Martín, M., Fernández-Ruiz, J.J.·1994·Life Sciences

DOI 10.1016/0024-3205(94)00585-0

Open this paper in CoChat — free account

Abstract

Cannabinoid effects on brain dopaminergic activity vary as a function of gonadal status. In this work, we examined whether these variations might be due to sex steroid-dependent differences in brain cannabinoid receptors (CNr). Four experiments were done: (i) male versus females; (ii) females at each stage of the ovarian cycle; (iii) estradiol (E2) and/or progesterone (P)-replaced ovariectomized (OVX) females; and (iv) testosterone (T)-replaced orchidectomized males. The density of CNr in the medial basal hypothalamus fluctuated in females during the estrous cycle. The density was higher in diestrus and decreased in estrus. This parameter did not change after ovariectomy and E2 replacement. However, P increased the density of CNr when administered to OVX rats acutely treated with E2, but not administered alone or after chronic E2 treatment. In the striatum, the affinity of CNr was slightly higher in males than females, with no changes in density. Ovariectomy increased the affinity of CNr, which normalized only after administration of acute E2. Interestingly, the high affinity values observed in this area after P alone or combined with E2, corresponded to low densities as compared with intact females. In the limbic forebrain, the affinity for the cannabinoid ligand was also higher in males than females with no changes in density. Affinity was also higher in diestrus and lower in estrus, whereas density was unchanged. Ovariectomy decreased CNr density. A normal situation was found after administration of acute E2 or P alone, whereas chronic E2 markedly increased the density of CNr as compared with both intact and OVX females. Interestingly, this latter increase was prevented by coadministration of P. Orchidectomy did not affect CNr density, but administration of T produced a marked decrease. In the mesencephalon, the density and affinity of CNr was higher in males than females. Administration of P to OVX rats produced opposite effects, increasing the density when administered alone and decreasing it when administered to acute E2-replaced OVX rats. In summary, these results reveal the existence of subtle, sometimes more pronounced, sex dimorphisms, fluctuations along the ovarian cycle and changes after gonadectomy and sex steroid replacement in CNr density and affinity in certain brain areas. This supports the hypothesis of possible sex steroid-dependent differences in the sensitivity of certain neuronal processes to cannabinoid treatment.

Integrity signals

Registry

Crossref · 10.1016/0024-3205(94)00585-0

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
Glowinski, J., & Iversen, L. L. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb09873.x · Cited by 5,436
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
Herkenham, M. A., Lynn, A. B., de Costa, B. R., & Richfield, E. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90970-7 · Cited by 515
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Howlett, A. C., Qualy, J. M., & Khachatrian, L. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10219-8 · Cited by 470
Δ9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis
Chen, J., Paredes, W. M., Li, J., Smith, D. M., Lowinson, J. H., & Gardner, E. L. (1990) · Psychopharmacology · doi:10.1007/bf02245916 · Cited by 329
Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model.
Howlett, A. C., Johnson, M. R., Melvin, L. S., & Milne, G. M. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13196-9 · Cited by 253

Show all 29 references

Research works printed but not linked: 13

Dill, 1988, J. Pharmacol. Exp. Ther., 244, 1157
Howlett, 1990, TINS, 13, 420
Devane, 1988, Mol. Pharmacol., 34, 605
Herkenham, 1990, 87, 1932
Howlett, 1986, Mol. Pharmacol., 29, 307
Dewey, 1986, Pharmacol. Rev., 38, 151
Howlett, 1988, Mol. Pharmacol., 33, 297
Pertwee, 1988, Neuropharmacology, 27, 1256
Bonnin, 1993, Neuroendocrinology
Gunnet, 1986, 183, 48
Bridgen, 1990, FASEB J., A996, 4240
Houston, 1991, Du Pont Biotech Update, 6, 21
de Fonseca, 1993, Pharmacol. Biochem. Behav.

Sorted by citations

Items 101–200 of 242

Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood
Borsoï, M., Manduca, A., Bara, A., Lassalle, O., Pélissier‐Alicot, A., & Manzoni, O. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00023 · Cited by 39
Cannabidiol has therapeutic potential for myofascial pain in female and male parkinsonian rats
Vivanco-Estela, A. N., Pereira, M. D. S., Guimarães, F. S., Bel, E. A. D., & Nascimento, G. C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108700 · Cited by 39
Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol
Silote, G. P., Gatto, M. C., Eskelund, A., Guimarães, F. S., Wegener, G., & Joca, S. R. L. (2021) · Pharmaceuticals · doi:10.3390/ph14121269 · Cited by 40
Effects of traditional herbal medicine on gastric mucin against ethanol-induced gastric injury in rats
Goso, Y., Ogata, Y., Ishihara, K., & Hotta, K. (1996) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/0742-8413(95)02042-x · Cited by 37
Sex differences in the cannabinoid regulation of energy homeostasis
Farhang, B., Diaz, S. V., Tang, S. L., & Wagner, E. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.007 · Cited by 37
Differential Expression of Brain Cannabinoid Receptors between Repeatedly Stressed Males and Females may Play a Role in Age and Gender-Related Difference in Traumatic Brain Injury: Implications from Animal Studies
Xing, G., Carlton, J. R., Jiang, X., Wen, J., Jia, M., & Li, H. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00161 · Cited by 39
Circulating Endocannabinoid Concentrations and Sexual Arousal in Women
Klein, C., Hill, M. N., Chang, S., Hillard, C. J., & Gorzalka, B. B. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02708.x · Cited by 36
Female but not male rats show biphasic effects of low doses of Δ9-tetrahydrocannabinol on anxiety: can cannabidiol interfere with these effects?
Salviato, B. Z., Raymundi, A. M., da Silva, T. R., Salemme, B. W., Sohn, J. M. B., de Araujo, F. S., Guimarães, F. S., Bertoglio, L. J., & Stern, C. A. J. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108684 · Cited by 35
Cannabinoid CB1 receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice
González, S. R., Mena, M. A., Lastres‐Becker, I., Serrano, A., de Yébenes, J. G., Ramos, J. A., & Fernández‐Ruíz, J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.010 · Cited by 35
Self-citation
Cannabinoids: Revealing their complexity and role in central networks of fear and anxiety
Murkar, A., Koninck, J. D., & Merali, Z. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.002 · Cited by 35
Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes
Keeley, R. J., Trow, J., & McDonald, R. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.024 · Cited by 33
Neuronal and Astroglial Response to Pre- and Perinatal Exposure to Delta-9-Tetra- Hydrocannabinol in the Rat Substantia nigra
Suárez, I., Bodega, G., Ramos, J. A., Fernández‐Ruíz, J., & Fernández, B. (2000) · Developmental Neuroscience · doi:10.1159/000017449 · Cited by 33
Self-citation
Cannabinoids and Reproduction: A Lasting and Intriguing History
Cacciola, G., Chianese, R., Chioccarelli, T., Ciaramella, V., Fasano, S., Pierantoni, R., Meccariello, R., & Cobellis, G. (2010) · Pharmaceuticals · doi:10.3390/ph3103275 · Cited by 33
Cannabinoid receptor expression and phosphorylation are differentially regulated between male and female cerebellum and brain stem after repeated stress: Implication for PTSD and drug abuse
Xing, G., Carlton, J. R., Zhang, L., Jiang, X., Fullerton, C. S., Li, H., & Ursano, R. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.013 · Cited by 35
Cannabinoid receptor antagonism increases female sexual motivation
López, H. H., Webb, S. A., & Nash, S. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.10.004 · Cited by 32
Prenatal Cannabinoid Exposure Down- Regulates Glutamate Transporter Expressions (GLAST and EAAC1) in the Rat Cerebellum
Suárez, I., Bodega, G., Rubio‐Terres, C., Fernández‐Ruíz, J., Ramos, J. A., & Fernández, B. (2004) · Developmental Neuroscience · doi:10.1159/000080711 · Cited by 31
Self-citation
Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies
Stuart, J. M., Paris, J. J., Frye, C. A., & Bradshaw, H. B. (2013) · International Journal of Endocrinology · doi:10.1155/2013/436252 · Cited by 31
The effect of anaesthesia on [18F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain
Casteels, C., Bormans, G. M., & Laere, K. V. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1383-7 · Cited by 27
Pretreatment with Δ9-tetrahydrocannabinol (THC) increases cocaine-stimulated activity in adolescent but not adult male rats
Dow-Edwards, D. L., & Izenwasser, S. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.09.003 · Cited by 27
Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring
Ramírez-López, M. T., Arco, R., Decara, J. M., Vázquez, M., Blanco, R. N., Alén, F., Suárez, J., de Heras, R. G., & de Fonseca, F. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165432 · Cited by 27
Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood‐placenta barrier
Moreno‐Sanz, G., Sasso, O., Guijarro, A. I., Oluyemi, O., Bertorelli, R., Reggiani, A. M., & Piomelli, D. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02098.x · Cited by 26
Sex Differences in a Rat Model of Peripheral Neuropathic Pain and Associated Levels of Endogenous Cannabinoid Ligands
Boullon, L., Finn, D. P., & Llorente‐Berzal, A. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.673638 · Cited by 28
Lipid endocannabinoids in energy metabolism, stress and developmental programming
de Almeida, M. M., Dias-Rocha, C. P., Calviño, C., & Trevenzoli, I. H. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111522 · Cited by 27
Gender Differences in Dual Diagnoses Associated with Cannabis Use: A Review
Arenas, L. P., Díaz, I., & Arenas, M. C. (2022) · Brain Sciences · doi:10.3390/brainsci12030388 · Cited by 28
Sex differences in the interactive effects of early life stress and the endocannabinoid system
Dow-Edwards, D. L. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106893 · Cited by 27
Effects of Δ9-THC on VIP-induced prolactin secretion in anterior pituitary cultures: evidence for the presence of functional cannabinoid CB1 receptors in pituitary cells
de Fonseca, F. R., Wenger, T., Navarro, M. A., & Murphy, L. L. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01809-0 · Cited by 26
Gonadal hormones do not alter the development of antinociceptive tolerance to delta-9-tetrahydrocannabinol in adult rats
Wakley, A. A., Wiley, J. L., & Craft, R. M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.021 · Cited by 26
EFFECTS OF CASTRATION ON CANNABINOID CB1RECEPTOR EXPRESSION AND ON THE BIOLOGICAL ACTIONS OF CANNABINOID IN THE PAROTID GLAND
Busch, L., Sterin‐Borda, L., & Borda, E. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04355.x · Cited by 25
Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes
Kim, H. J. J., Zagzoog, A., Black, T., Baccetto, S. L., Ezeaka, U. C., & Laprairie, R. B. (2022) · Pharmacology Research & Perspectives · doi:10.1002/prp2.950 · Cited by 22
Cyclic ovarian hormone modulation of supraspinal Δ9-tetrahydrocannabinol-induced antinociception and cannabinoid receptor binding in the female rat
Wakley, A. A., McBride, A. A., Vaughn, L. K., & Craft, R. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.007 · Cited by 23
Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice.
Kalbasi Anaraki, D., Sianati, S., Sadeghi, M., Ghasemi, M., Javadi, P., Ejtemaei Mehr, S., & Dehpour, A. R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.055 · Cited by 22
Endocannabinoid System and Metabolism: The Influences of Sex
Forner-Piquer, I., Giommi, C., Sella, F., Lombó, M., Montik, N., Valle, L. D., & Carnevali, O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211909 · Cited by 23
Antiseizure effects of the cannabinoids in the amygdala‐kindling model
Fallah, M. S., Dlugosz, L., Scott, B. W., Thompson, M. D., & Burnham, W. M. (2021) · Epilepsia · doi:10.1111/epi.16973 · Cited by 25
Long-term behavioural and neuroendocrine effects of perinatal activation or blockade of CB1 cannabinoid receptors
Moreno, M., Escuredo, L., oz, R. M., de Fonseca, F. R., & Navarro, M. A. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00015 · Cited by 22
Endocannabinoid system contributions to sex-specific adolescent neurodevelopment
Simone, J. J., Green, M. R., & McCormick, C. M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110438 · Cited by 25
Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators
Ramírez-López, M. T., Arco, R., Decara, J. M., Vázquez, M., Rivera, P., Blanco, R. N., Alén, F., de Heras, R. G., Suárez, J., & de Fonseca, F. R. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00241 · Cited by 21
Ovarian hormones and chronic administration during adolescence modify the discriminative stimulus effects of delta-9-tetrahydrocannabinol (Δ9-THC) in adult female rats
Winsauer, P. J., Filipeanu, C. M., Bailey, E., Hulst, J. L., & Sutton, J. L. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.06.008 · Cited by 21
Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model
Molina, P. E., Amedee, A. M., Winsauer, P. J., Nelson, S., Bagby, G., & Simon, L. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9599-8 · Cited by 20
Sex differences in the effect of cannabinoid type 1 receptor deletion on locus coeruleus‐norepinephrine neurons and corticotropin releasing factor‐mediated responses
Wyrofsky, R. R., Reyes, B. A. S., Yu, D., Kirby, L. G., & Bockstaele, E. J. V. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14103 · Cited by 20
Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats
Lamota, L., Bermúdez‐Silva, F. J., Marco, E. M., Llorente, R., Gallego, A., de Fonseca, F. R., & Viveros, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.004 · Cited by 20
Endocannabinoid System Changes throughout Life: Implications and Therapeutic Potential for Autism, ADHD, and Alzheimer’s Disease
Dallabrida, K. G., Bender, J. M. D. O., Chade, E. S., Rodrigues, N., & Sampaio, T. B. (2024) · Brain Sciences · doi:10.3390/brainsci14060592 · Cited by 21
Effects of CB1 receptor agonism and antagonism on behavioral fear and physiological stress responses in adult intact, ovariectomized, and estradiol-replaced female rats
Simone, J. J., Malivoire, B. L., & McCormick, C. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.032 · Cited by 24
Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB1R expression or estrous cyclicity
Chadwick, B. J., Saylor, A. J., & López, H. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.006 · Cited by 19
Chronic Δ 9 -Tetrahydrocannabinol Administration May Not Attenuate Simian Immunodeficiency Virus Disease Progression in Female Rhesus Macaques
Amedee, A. M., Nichols, W. A., LeCapitaine, N. J., Stouwe, C. V., Birke, L. L., Lacour, N., Winsauer, P. J., & Molina, P. E. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0108 · Cited by 19
Effect of the Estrous Cycle on Olfactory Bulb Response to Vaginocervical Stimulation in the Rat
Guevara‐Guzmán, R., Barrera‐Mera, B., & Weiss, M. L. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00103-2 · Cited by 19
Sex‐specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats
Simone, J. J., Baumbach, J. L., & McCormick, C. M. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.07.011 · Cited by 18
Sex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC)
Nia, A. B., Orejarena, M. J., Flynn, L. T., Luddy, C., D’Souza, D. C., Skosnik, P. D., Pittman, B. P., & Ranganathan, M. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06135-3 · Cited by 17
Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression
Bernabeu, A., Bara, A., Murphy, M. N., Manduca, A., Wager‐Miller, J., Borsoï, M., Lassalle, O., Pélissier‐Alicot, A., Chavis, P., Mackie, K., et al. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0308 · Cited by 20
Sex Differences in Plasma, Adipose Tissue, and Central Accumulation of Cannabinoids, and Behavioral Effects of Oral Cannabis Consumption in Male and Female C57BL/6 Mice
Sallam, N. A., Peterson, C. S., Baglot, S. L., Kohro, Y., Trang, T., Hill, M. N., & Borgland, S. L. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad055 · Cited by 17
Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking
Fabian, C. B., Jordan, N. D., Cole, R. H., Carley, L. G., Thompson, S. M., Seney, M. L., & Joffe, M. E. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01889-0 · Cited by 19
FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex
Flannery, L. E., Henry, R. J., Kerr, D. M., Finn, D. P., & Roche, M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24120 · Cited by 19
Acute cannabinoid administration attenuates female socio-sexual motivation
López, H. H., Zappia, K. J., Cushman, C. L., & Chadwick, B. J. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.11.002 · Cited by 17
Progesterone receptor and dopamine receptors are required in Δ 9 -tetrahydrocannabinol modulation of sexual receptivity in female rats
Mani, S. K., Mitchell, A., & O’Malley, B. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1249 · Cited by 17
Sexually Dimorphic Expression of Fear-conditioned Analgesia in Rats and Associated Alterations in the Endocannabinoid System in the Periaqueductal Grey
Llorente‐Berzal, A., McGowan, F., Gaspar, J. C., Rea, K., Roche, M., & Finn, D. P. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.005 · Cited by 16
Effect of FRG-8813, a New-Type Histamine H2-Receptor Antagonist, on the Recurrence of Gastric Ulcer after Healing by Drug Treatment in Rats
Ajioka, H., Miyake, H., & Matsuura, N. (2000) · Pharmacology · doi:10.1159/000028385 · Cited by 16
?9-Tetrahydrocannabinol affects mesolimbic dopaminergic activity in the female rat brain: interactions with estrogens
Bonnin, A., Fern�ndez-Ruiz, J. J., Mart�n, M., de Fonseca, F. R. G., Hern�ndez, M. L., & Ramos, J. A. (1993) · Journal of Neural Transmission · doi:10.1007/bf01244868 · Cited by 16
Self-citation
Effects of endocannabinoid system modulation on social behaviour: A systematic review of animal studies
Ahmed, M., Best, L. M., Pereira, C. F., Boileau, I., & Kloiber, S. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104680 · Cited by 14
Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress‐related behaviour and drinking in Marchigian Sardinian alcohol‐preferring rats
Vozella, V., Cruz, B., Feldman, H. C., Bullard, R., Bianchi, P., Natividad, L. A., Cravatt, B. F., Zorrilla, E. P., Ciccocioppo, R., & Roberto, M. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16197 · Cited by 15
Peripheral endocannabinoids in major depressive disorder and alcohol use disorder: a systematic review
Fuentes, J. J., Mayans, J., Guarro, M., Canosa, I., Mestre-Pintó, J. I., Fonseca, F., & Torrens, M. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05986-8 · Cited by 14
The Estrous Cycle Influences the Effects of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibition in the Anxiety-Like Behavior in Rats
Salemme, B. W., Raymundi, A. M., Sohn, J. M. B., & Stern, C. A. J. (2023) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0329 · Cited by 12
Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Rat and Human Spinal Cord
Parnell, J., Martin, N., Dedek, A., Rudyk, C., Landrigan, J., Bellavance, J., VanDerLoo, S., Tsai, E. C., & Hildebrand, M. E. (2023) · Canadian Journal of Pain · doi:10.1080/24740527.2023.2264895 · Cited by 14
Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study
Aghaei, A. M., Spillane, L. U., Pittman, B. P., Flynn, L. T., Aquino, J. P. D., Nia, A. B., & Ranganathan, M. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06625-6 · Cited by 13
Sex differences in cocaine-associated memory: The interplay between CB1, mGluR5, and estradiol
Chang, H.-A., Dai, W., & Hu, S. S. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105366 · Cited by 13
The endocannabinoid system and breathing
Wiese, B. M., Reyes, A. A., Vanderah, T. W., & Largent‐Milnes, T. M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1126004 · Cited by 12
Gender Differences in Cannabis Addiction and Dependence
Davis, C. A., & Fattore, L. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_12 · Cited by 12
In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors
Kim, H. J. J., Zagzoog, A., Smolyakova, A.-M., Ezeaka, U. C., Benko, M. J., Holt, T., & Laprairie, R. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.790546 · Cited by 12
Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
Yadav-Samudrala, B. J., Dodson, H., Ramineni, S., Kim, E., Poklis, J. L., Lu, D., Ignatowska-Jankowska, B. M., Lichtman, A. H., & Fitting, S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305868 · Cited by 11
Maternal Immune Activation and the Endocannabinoid System: Focus on Two-Hit Models of Schizophrenia
Santoni, M., & Pistis, M. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.11.015 · Cited by 13
Sex-specific mechanisms of tolerance for the cannabinoid agonists CP55,940 and delta-9-tetrahydrocannabinol (Δ9-THC)
Henderson, A. N., Sepúlveda, D. E., Ferguson, E. L., Kline, A. M., Piscura, M. K., & Morgan, D. J. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05886-9 · Cited by 11
PET Imaging of Endocannabinoid System
Horti, A. G., Raymont, V., & Terry, G. E. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_11 · Cited by 11
Endocannabinoid influence on partner preference in female rats
Memos, N. K., Vela, R., Tabone, C., & Guarraci, F. A. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.07.010 · Cited by 11
Antinociceptive effects of JWH015 in female and male rats
Craft, R. M., Greene, N. Z., & Wakley, A. A. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000337 · Cited by 11
Molecular and cellular mechanisms underlying brain region-specific endocannabinoid system modulation by estradiol across the rodent estrus cycle
Kim, H. J. J., Zagzoog, A., Black, T., Baccetto, S. L., & Laprairie, R. B. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.06.010 · Cited by 10
The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning & Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats
Haghparast, E., Sheibani, V., Komeili, G., Chahkandi, M., & Rad, N. S. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03899-8 · Cited by 10
Cannabinoids and chronic pelvic pain in women: Focus on endometriosis
Marcu, I., Gee, A. D., & Lynn, B. (2021) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/22840265211011277 · Cited by 10
How might cannabinoids influence sexual behavior?
Stella, N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.793 · Cited by 10
Sex-specific maturational trajectory of endocannabinoid plasticity in the rat prefrontal cortexPreprint
Bernabeu, A., Bara, A., Manduca, A., Borsoï, M., Lassalle, O., Pélissier‐Alicot, A., & Manzoni, O. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.09.332965 · Cited by 10
Somatic and Anxiety-Like Behaviors in Male and Female Rats During Withdrawal from the Non-Selective Cannabinoid Agonist Win 55,212-2
Brewer, A. L., Felter, C. E., Sternitzky, A. R., & Spencer, S. M. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173707 · Cited by 9
The endocannabinoid and paracannabinoid systems in natural reward processes: possible pharmacological targets?
Friuli, M., Eramo, B., Sepe, C., Kiani, M., Casolini, P., & Zuena, A. R. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114929 · Cited by 11
Sex Differences in the Safety and Subjective Effects of Two Oral Δ9-Tetrahydrocannabinol-Containing Cannabis Products over Multiple Doses Among Healthy Adults
MacNair, L., Eglit, G. M. L., Mosesova, I., Bonn‐Miller, M. O., & Peters, E. N. (2023) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0340 · Cited by 9
Chronic administration during early adulthood does not alter the hormonally-dependent disruptive effects of delta-9-tetrahydrocannabinol (Δ9-THC) on complex behavior in female rats
Winsauer, P. J., & Sutton, J. L. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.12.014 · Cited by 9
Exposure to a high-fat diet decreases sensitivity to Δ9-tetrahydrocannabinol-induced motor effects in female rats
Wiley, J. L., Jones, A. R., & Wright, M. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.010 · Cited by 9
Sex differences in acute delta-9-tetrahydrocannabinol (Δ9-THC) response and tolerance as a function of mouse strain
Lulek, C. F., Maulik, M., Mitra, S., Guindon, J., Morgan, D. J., & Henderson, A. N. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06421-8 · Cited by 10
Adolescent cannabinoid treatment negatively affects reproductive behavior in female rats
Minney, S. M., & López, H. H. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.015 · Cited by 8
Sex‐specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord
Zhang, Y., Ke, J., Zhou, Y., Liu, X., Huang, T., & Wang, L. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25342 · Cited by 7
“Weeding out” violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression
Bortolato, M., Braccagni, G., Pederson, C. A., Floris, G., & Fite, P. J. (2024) · Aggression and Violent Behavior · doi:10.1016/j.avb.2024.101948 · Cited by 7
Do Adolescent Exposure to Cannabinoids and Early Adverse Experience Interact to Increase the Risk of Psychiatric Disorders: Evidence from Rodent Models
Portugalov, A., & Akirav, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020730 · Cited by 8
Region-Specific Impact of Repeated Synthetic Cannabinoid Exposure and Withdrawal on Endocannabinoid Signaling, Gliosis, and Inflammatory Markers in the Prefrontal Cortex and Hippocampus
Vadas, E., López-Gambero, A. J., Vargas, A., Rodríguez-Pozo, M., Rivera, P., Decara, J. M., Serrano, A., Martín‐de‐las‐Heras, S., de Fonseca, F. R., & Suárez, J. (2025) · Biomolecules · doi:10.3390/biom15030417 · Cited by 6
Correlations of the CNR1 Gene with Personality Traits in Women with Alcohol Use Disorder
Maciocha, F., Suchanecka, A., Chmielowiec, K., Chmielowiec, J., Ciechanowicz, A., & Boroń, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105174 · Cited by 6
How CB1 Receptor Activity and Distribution Contribute to Make the Male and Female Brain Different Toward Cannabinoid-Induced Effects
Antinori, S., & Fattore, L. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_2 · Cited by 6
Sex‐dependent pharmacological profiles of the synthetic cannabinoid MMB‐Fubinaca
da Cruz, J. F. O., Ioannidou, C., Zottola, A. C. P., Muguruza, C., Gómez-Sotres, P., Fernández‐Monreal, M., Callado, L. F., Marsicano, G., & Busquets-García, A. (2020) · Addiction Biology · doi:10.1111/adb.12940 · Cited by 6
Cannabinoid receptor Type 1 densities reflect social organization in Microtus
Simmons, T. C., Freeman, S. M., Lackey, N. S., Dreyer, B. K., Manoli, D. S., & Bales, K. L. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24996 · Cited by 6
The impact of pregnancy and associated hormones on the pharmacokinetics of Δ 9 -tetrahydrocannabinol
Authement, A. K., & Isoherranen, N. (2024) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2024.2309213 · Cited by 5
Association Between Hormonal Birth Control, Substance Use, and Depression
Newman, S. D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.772412 · Cited by 5
A variant on promoter of the cannabinoid receptor 1 gene (CNR1) moderates the effect of valence on working memory
Fairfield, B., Mammarella, N., Franzago, M., Domenico, A. D., Stuppia, L., & Gatta, V. (2017) · Memory · doi:10.1080/09658211.2017.1347685 · Cited by 5
PET Imaging of the Endocannabinoid System
Terry, G. E., Raymont, V., & Horti, A. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_12 · Cited by 5
Age-dependent effects of estradiol on temporal memory: A role for the type 1 cannabinoid receptor?
Potier, M., Maître, M., Lesté-Lasserre, T., Marsicano, G., Chaouloff, F., & Marighetto, A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.106002 · Cited by 4
The interaction of membrane estradiol receptors and metabotropic glutamate receptors in adaptive and maladaptive estradiol-mediated motivated behaviors in females
Johnson, C. S., & Mermelstein, P. G. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.11.001 · Cited by 4
Association of cannabis use with depression among cancer patients
Hu, S., Lin, A., Luo, P., & Zhang, J. (2023) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2023.102304 · Cited by 4
Basolateral amygdala cannabinoid CB1 receptors mediate the antinociceptive activity of harmaline in adolescent male mice
Alijanpour, S., Ghasemzadeh, Z., Ebrahimi-Ghiri, M., & Zarrindast, M. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113886 · Cited by 5

Authors: de Fonseca, F. R., Cebeira, M., Ramos, J. A., Martín, M., & Fernández-Ruiz, J. J.
Affiliations: Universidad Complutense de Madrid (ES)
ORCID: Martín, M.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 1994-01
Volume: 54
Issue: 3
Pages: 159-170
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/0024-3205(94)00585-0
OpenAlex: W2056795643
Cited by: 243
References: 29
Citations by year: 2026: 6 · 2025: 9 · 2024: 11 · 2023: 18 · 2022: 12 · 2021: 18 · 2020: 14 · 2019: 4 · 2018: 10 · 2017: 12 · 2016: 8 · 2015: 11 · 2014: 9 · 2013: 9 · 2012: 9
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: cannabinoid receptors, sex differences, estrous cycle, gonadectomy, estradiol, progesterone, testosterone, ovariectomy, orchiectomy, receptor density, receptor binding affinity, medial basal hypothalamus, striatum, limbic forebrain, midbrain, dopaminergic activity, gonadal status
MeSH terms: Animals, Brain, Cannabinoids, Cyclohexanols, Dopamine, Estradiol, Estrus, Female, Kinetics, Male, Neurons, Orchiectomy, Ovariectomy, Ovary, Progesterone, Receptors, Drug, Sex Characteristics, Testis, Testosterone, Dronabinol, Tritium, Rats, Wistar, Receptors, Cannabinoid, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks