Reverse T3 or perverse T3? Still puzzling after 40 years
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Four decades after reverse T3 (3,3′5′-triiodothyronine) was discovered, its physiologic and clinical relevance remains unclear and is still being studied. But scientific uncertainty has not stopped writers in the consumer press and on the Internet from making unsubstantiated claims about this
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Treatment decisions based on rT3 levels may lead to the use of excessive doses of levothyroxine, resulting in subclinical or overt hyperthyroidism.
“Treatment decisions based on rT3 levels may lead to the use of excessive doses of levothyroxine, resulting in a state of subclinical or even overt hyperthyroidism (4).”
From Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? (2019) · cites this paper as [4]
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Research works printed but not linked: 1
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Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism?
Gomes-Lima, C., Wartofsky, L., & Burman, K. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00856 · Cited by 15 · see citing works
“Treatment decisions based on rT3 levels may lead to the use of excessive doses of levothyroxine, resulting in a state of subclinical or even overt hyperthyroidism (4).”
BackgroundSelf-citationKöhrle, J., & Richards, K. H. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1175-4610 · Cited by 7 · see citing works
- Authors
- Gomes-Lima, C., & Burman, K. D.
- Affiliations
- MedStar Washington Hospital Center (US)
- Venue
- Cleveland Clinic Journal of Medicine
- Publisher
- Cleveland Clinic Journal of Medicine
- Published
- 2018-06
- Volume
- 85
- Issue
- 6
- Pages
- 450-455
- ISSN
- 0891-1150 (ISSN-L)
- 1939-2869
- OpenAlex
- W2808596768
- Cited by
- 11
- References
- 31
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 5
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cleveland Clinic Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- reverse T3, thyroid hormone metabolism, thyroid function
- MeSH terms
- Humans, Thyroid Diseases, Triiodothyronine, Reverse
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